Results 1 to 10 of about 159 (75)
Toxicology of haloacetonitriles. [PDF]
Environmental Health Perspectives, 1986 Haloacetonitriles are by-products of water chlorination and may form in vivo from the reaction of residual chlorine with endogenous compounds such as amino acids. Dibromoacetonitrile (DBAN) was negative in selected mutagenic assays; dichloroacetonitrile (DCAN) was mutagenic in S. typhimurium, but not in S. cerevisiae.
Joseph F. Borzelleca +2 more
openaire +3 more sources
Optimal designs for dose-finding experiments in toxicity studies [PDF]
Bernoulli 2009, Vol. 15, No. 1, 124-145, 2009 We construct optimal designs for estimating fetal malformation rate, prenatal death rate and an overall toxicity index in a toxicology study under a broad range of model assumptions. We use Weibull distributions to model these rates and assume that the number of implants depend on the dose level.
arxiv +1 more source
D-optimal Approximate Design for Binary Regression and Quantal Response in Toxicology Studies [PDF]
arXiv, 2022 We provide a systematic treatment of $D$-optimal design for binary regression and quantal response models in toxicology studies. For the two-parameter case, we provide an analytical equation (WC equation) for computing the $D$-optimal design quickly and when analytical solution is not available, we apply particle swarm optimization to solve for the $D$-
arxiv
The Toxicology of Benzene [PDF]
Environmental Health Perspectives, 1993 Benzene is metabolized, primarily in the liver, to a series of phenolic and ring-opened products and their conjugates. The mechanism of benzene-induced aplastic anemia appears to involve the concerted action of several metabolites acting together on early stem and progenitor cells, as well as on early blast cells, such as pronormoblasts and normoblasts
Bernard D. Goldstein +2 more
openaire +3 more sources
Diagnosis of Acute Poisoning Using Explainable Artificial Intelligence [PDF]
arXiv, 2021 Medical toxicology is the clinical specialty that treats the toxic effects of substances, be it an overdose, a medication error, or a scorpion sting. The volume of toxicological knowledge and research has, as with other medical specialties, outstripped the ability of the individual clinician to entirely master and stay current with it.
arxiv
Integrating Biological Knowledge in Kernel-Based Analyses of Environmental Mixtures and Health [PDF]
arXiv, 2022 A key goal of environmental health research is to assess the risk posed by mixtures of pollutants. As epidemiologic studies of mixtures can be expensive to conduct, it behooves researchers to incorporate prior knowledge about mixtures into their analyses.
arxiv
The R package predint: Prediction intervals for overdispersed binomial and Poisson data or based on linear random effects models in R [PDF]
arXiv, 2022 A prediction interval is a statistical interval that should encompass one (or more) future observation(s) with a given coverage probability and is usually computed based on historical control data. The application of prediction intervals is discussed in many fields of research, such as toxicology, pre-clinical statistics, engineering, assay validation ...
arxiv
, 2015 With the financial support of Internal Security Fund Police Programme European Commission Directorate General Home Affairs. This project has been founded with support from the European Commission. This publication reflects the views only of the authors, and European Commission cannot be held responsible for any use which may be made of the information ...
openaire +3 more sources
A statistical method for estimating the no-observed-adverse-event-level [PDF]
arXiv, 2021 In toxicological risk assessment the benchmark dose (BMD) is recommended instead of the no-observed-adverse effect-level (NOAEL). Still a simple test procedure to estimate NOAEL is proposed here, explaining its advantages and disadvantages. Versatile applicability is illustrated using four different data examples of selected in vivo toxicity bioassays.
arxiv
Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology [PDF]
arXiv, 2020 To claim similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology is a relevant issue during the assay validation process. Here we demonstrated the use of dose-by-laboratory interaction contrasts, particularly Williams-type by total mean contrasts.
arxiv