Results 1 to 10 of about 28,372 (204)

Modeling sRNA-Regulated Plasmid Maintenance. [PDF]

PLoS ONE, 2017
We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj   +4 more sources

Chaperone addiction of toxin–antitoxin systems [PDF]

Nature Communications, 2016
Some bacterial toxin-antitoxin systems consist of a labile antitoxin that inhibits a toxin, and a chaperone that stabilizes the antitoxin. Here, Bordes et al.
Patricia Bordes, Ambre Julie Sala, Sara Ayala, Pauline Texier, Nawel Slama, Anne-Marie Cirinesi, Valérie Guillet, Lionel Mourey, Pierre Genevaux   +8 more
doaj   +2 more sources

Mechanisms for Differential Protein Production in Toxin–Antitoxin Systems [PDF]

Toxins, 2017
Toxin–antitoxin (TA) systems are key regulators of bacterial persistence, a multidrug-tolerant state found in bacterial species that is a major contributing factor to the growing human health crisis of antibiotic resistance. Type II TA systems consist of
Heather S. Deter, Roderick V. Jensen, William H. Mather, Nicholas C. Butzin   +3 more
doaj   +2 more sources

Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems [PDF]

Frontiers in Molecular Biosciences, 2016
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan, Manuel eEspinosa, Chew Chieng eYeo   +2 more
doaj   +5 more sources

Bioinformatic exploration reveals features of tenpIN family of type III toxin-antitoxin systems in bacteria and viruses [PDF]

Scientific Reports
Toxin-antitoxin (TA) systems in bacteria consist of two genes: one encoding a toxin that inhibits essential cellular processes and the other encoding an antitoxin that neutralizes the toxin under homeostatic conditions.
Kavyashree Nadig, Sankaran Sandhya, Mahavir Singh   +2 more
doaj   +2 more sources

Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis [PDF]

Infection and Immunity
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner, Samantha D’Spain, Rachel Ende, Isabelle Derré   +3 more
doaj   +2 more sources

The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation [PDF]

Microorganisms
Toxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo, Deborah Kohn Damiano, Aline Florencio Teixeira, Ana Lucia Tabet Oller Nascimento, Luis Guilherme Virgilio Fernandes, Alexandre Paulo Yague Lopes   +5 more
doaj   +2 more sources

Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]

Communications Biology
The VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh, Gopinath Chattopadhyay, Niranjana Sri Sundaramoorthy, Raghavan Varadarajan, Ramandeep Singh   +4 more
doaj   +2 more sources

Design of Specific Peptide Inhibitors of Toxin-Antitoxin-Mediated Antiphage Defense. [PDF]

ACS Synth Biol
Ghose DA, Swanson SR, Birnbaum F, Britton D, Gan JL, Mahoney EM, Laub MT, Keating AE.   +7 more
europepmc   +2 more sources

Large-scale Purification of Type III Toxin-antitoxin Ribonucleoprotein Complex and its Components from Escherichia coli for Biophysical Studies

Bio-Protocol, 2023
Toxin–antitoxin (TA) systems are widespread bacterial immune systems that confer protection against various environmental stresses. TA systems have been classified into eight types (I–VIII) based on the nature and mechanism of action of the antitoxin ...
Parthasarathy Manikandan, Kavyashree Nadig, Mahavir Singh   +2 more
doaj   +1 more source