Keeping the Wolves at Bay: Antitoxins of Prokaryotic Type II Toxin-Antitoxin Systems [PDF]
Frontiers in Molecular Biosciences, 2016 In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Manuel Espinosa, Chew Chieng Yeo
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Frontiers in Microbiology, 2021 The bloom-forming cyanobacterium Microcystis aeruginosa is known for its global distribution and for the production of toxic compounds. In the genome of M.
Marina Klemenči, Marko Dolinar
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Control of Toxin-Antitoxin Systems by Proteases in Mycobacterium Tuberculosis
Frontiers in Molecular Biosciences, 2021 Toxin-antitoxin (TA) systems are small genetic elements composed of a noxious toxin and a counteracting cognate antitoxin. Although they are widespread in bacterial chromosomes and in mobile genetic elements, their cellular functions and activation ...
Satoko Hakeda-suzuki, Pierre Genevaux
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The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation [PDF]
MicroorganismsToxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo +5 more
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Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
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Toxin-antitoxin genes are differentially expressed in Escherichia coli relA and spoT mutans cultured under nitrogen, fatty acid, or carbon starvation conditions [PDF]
Frontiers in MicrobiologyIntroductionThe stringent response is one of the fundamental mechanisms that control and modulate bacterial adaptation to stress conditions, such as nutrient limitation.
Monika Maciąg-Dorszyńska +3 more
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Regulation of Type II Toxin-Antitoxin Systems: The Translation-Responsive Model
Frontiers in Microbiology, 2020 Most bacterial genomes encode multiple autoregulatory “poison-antidote” gene pairs called Toxin-Antitoxin systems (TAs). They encode a “toxin” that inhibits metabolism and an “antitoxin” that inhibits the activity of toxin protein.
Bhaskar Chandra Mohan Ramisetty
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Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology
Molecular Cell, 2018 Alexander Harms +2 more
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Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens
Nature Communications, 2023 CRISPR-regulated toxin-antitoxin (CreTA), safeguards CRISPR-Cas immune systems. Here the authors characterize a bacterial CreTA and use this to generate a proof-of-concept antimicrobial strategy, ATTACK, which associates TA and CRISPR-Cas to kill ...
Rui Wang +11 more
semanticscholar +1 more source