Results 31 to 40 of about 99,158 (152)

Molecular Characterization of SehB, a Type II Antitoxin of Salmonella enterica Serotype Typhimurium: Amino Acid Residues Involved in DNA-Binding, Homodimerization, Toxin Interaction, and Virulence

open access: yesFrontiers in Microbiology, 2020
Salmonella enterica serotype Typhimurium is a bacterium that causes gastroenteritis and diarrhea in humans. The genome of S. Typhimurium codes for diverse virulence factors, among which are the toxin-antitoxin (TA) systems.
Fernando Chimal-Cázares   +14 more
doaj   +1 more source

The Bacillus cereus spoIIS programmed cell death system

open access: yesFrontiers in Microbiology, 2015
Programmed cell death in bacteria is generally associated with two¬ component toxin antitoxin systems. The SpoIIS toxin-antitoxin system, consisting of a membrane bound SpoIISA toxin and a small, cytosolic antitoxin SpoIISB, was originally identified in ...
Jana eMelnicakova   +3 more
doaj   +1 more source

THE NATURE OF THE TOXIN-ANTITOXIN FLOCCULATION PHENOMENON [PDF]

open access: yesJournal of Experimental Medicine, 1926
1. Animals immunized with the formalinized filtrates of young toxic cultures of B. botulinus produce an antitoxic serum poor in precipitins. 2. Animals immunized with the formalinized filtrates of old and partly autolyzed toxic cultures produce an antitoxic serum containing precipitins. 3. Animals immunized with toxin-free
J J, Bronfenbrenner, P, Reichert
openaire   +2 more sources

Expression, Purification, and Functional Analysis of Novel RelE Operon from X. nematophila

open access: yesThe Scientific World Journal, 2014
Bacterial toxin-antitoxin (TA) complexes induce programmed cell death and also function to relieve cell from stress by various response mechanisms. Escherichia coli RelB-RelE TA complex consists of a RelE toxin functionally counteracted by RelB antitoxin.
Jitendra Singh Rathore   +1 more
doaj   +1 more source

Toxin-Antitoxin Systems of Staphylococcus aureus [PDF]

open access: yesToxins, 2016
Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins. Dependent on the chemical nature of the antitoxins (protein or RNA) and how they control the activity of the toxin, TA systems are currently divided ...
Christopher Schuster, Ralph Bertram
openaire   +4 more sources

sRNA Antitoxins: More than One Way to Repress a Toxin

open access: yesToxins, 2014
Bacterial toxin-antitoxin loci consist of two genes: one encodes a potentially toxic protein, and the second, an antitoxin to repress its function or expression. The antitoxin can either be an RNA or a protein.
Jia Wen, Elizabeth M. Fozo
doaj   +1 more source

Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms.

open access: yesPLoS Genetics, 2021
Biofilms are multispecies communities, in which bacteria constantly compete with one another for resources and niches. Bacteria produce many antibiotics and toxins for competition.
Kazuo Kobayashi
doaj   +1 more source

Toxin-Antitoxin Systems and Persistence

open access: yes, 2019
Toxin-antitoxin (TA) systems are small genetic modules comprising a stable toxic protein and an antitoxin preventing the toxin activity. In type II TA systems, antitoxins are unstable proteins that are degraded by host ATP-dependent proteases. In steady-state conditions, the antitoxin forms a complex with the toxin in which the toxic activity is ...
Fraikin, Nathan   +2 more
openaire   +2 more sources

A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria

open access: yesNature Communications, 2022
Antimicrobial toxins are secreted by bacteria to kill rival species. Here the authors report the mechanism of inhibition of EsaD, a toxin secreted by some S.
Yongjin Wang   +17 more
doaj   +1 more source

The Haemophilus influenzae HipBA toxin–antitoxin system adopts an unusual three-component regulatory mechanism

open access: yesIUCrJ, 2022
Type II toxin–antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein–protein interactions.
Ji Sung Koo   +4 more
doaj   +1 more source

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