Results 21 to 30 of about 18,474 (175)
Frontiers in Microbiology, 2021 The bloom-forming cyanobacterium Microcystis aeruginosa is known for its global distribution and for the production of toxic compounds. In the genome of M.
Marina Klemenčič +2 more
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Nature Communications, 2023 Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu +9 more
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Antitoxin ε Reverses Toxin ζ-Facilitated Ampicillin Dormants
Toxins, 2020 Toxin-antitoxin (TA) modules are ubiquitous in bacteria, but their biological importance in stress adaptation remains a matter of debate. The inactive ζ-ε2-ζ TA complex is composed of one labile ε2 antitoxin dimer flanked by two stable ζ toxin monomers ...
María Moreno-del Álamo +2 more
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mBio, 2019 Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin +3 more
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A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli. [PDF]
PLoS Computational Biology, 2013 Toxin-Antitoxin modules are small operons involved in stress response and persister cell formation that encode a "toxin" and its corresponding neutralizing "antitoxin".
Lendert Gelens +4 more
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Mechanisms for Differential Protein Production in Toxin–Antitoxin Systems
Toxins, 2017 Toxin–antitoxin (TA) systems are key regulators of bacterial persistence, a multidrug-tolerant state found in bacterial species that is a major contributing factor to the growing human health crisis of antibiotic resistance. Type II TA systems consist of
Heather S. Deter +3 more
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The vapB-vapC operon of Acidovorax citrulli functions as a bona-fide toxin-antitoxin module
Frontiers in Microbiology, 2016 Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific,
Reut eShavit +4 more
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Toxin-antitoxin systems in bacterial pathogenesis
Heliyon, 2023 Toxin-Antitoxin (TA) systems are abundant in prokaryotes and play an important role in various biological processes such as plasmid maintenance, phage inhibition, stress response, biofilm formation, and dormant persister cell generation. TA loci are abundant in pathogenic intracellular micro-organisms and help in their adaptation to the harsh host ...
Sonika Sonika +3 more
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THE NATURE OF THE TOXIN-ANTITOXIN FLOCCULATION PHENOMENON [PDF]
Journal of Experimental Medicine, 1926 1. Animals immunized with the formalinized filtrates of young toxic cultures of B. botulinus produce an antitoxic serum poor in precipitins. 2. Animals immunized with the formalinized filtrates of old and partly autolyzed toxic cultures produce an antitoxic serum containing precipitins. 3. Animals immunized with toxin-free
J J, Bronfenbrenner, P, Reichert
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Toxin-Antitoxin Systems and Persistence
, 2019 Toxin-antitoxin (TA) systems are small genetic modules comprising a stable toxic protein and an antitoxin preventing the toxin activity. In type II TA systems, antitoxins are unstable proteins that are degraded by host ATP-dependent proteases. In steady-state conditions, the antitoxin forms a complex with the toxin in which the toxic activity is ...
Fraikin, Nathan +2 more
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