Results 21 to 30 of about 144,728 (208)

Toxin-antitoxins and bacterial virulence [PDF]

FEMS Microbiology Reviews, 2016
Bacterial virulence relies on a delicate balance of signals interchanged between the invading microbe and the host. This communication has been extensively perceived as a battle involving harmful molecules produced by the pathogen and host defenses. In this review, we focus on a largely unexplored element of this dialogue, as are toxin-antitoxin (TA ...
Lobato-Márquez, D, Díaz-Orejas, R, García-del Portillo, F   +2 more
openaire   +3 more sources

The Cysteine Protease MaOC1, a Prokaryotic Caspase Homolog, Cleaves the Antitoxin of a Type II Toxin-Antitoxin System

Frontiers in Microbiology, 2021
The bloom-forming cyanobacterium Microcystis aeruginosa is known for its global distribution and for the production of toxic compounds. In the genome of M.
Marina Klemenčič, Ana Halužan Vasle, Marko Dolinar   +2 more
doaj   +1 more source

MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

Nature Communications, 2023
Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu, Ben Usher, Claude Gutierrez, Roland Barriot, Tom J. Arrowsmith, Xue Han, Peter Redder, Olivier Neyrolles, Tim R. Blower, Pierre Genevaux   +9 more
doaj   +1 more source

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J., Leighton A. Turner, Daniel J. Rankin, Heinemann, Jack A., Brown, Sam P., Sam P. Brown, Turner, Leighton A., Jack A. Heinemann   +7 more
core   +1 more source

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin [PDF]

, 2016
FIC domain proteins mediate post-translational modifications of target proteins, which typically results in their inactivation. Depending on the conservation of crucial active site residues, the FIC fold serves as structural scaffold for various ...
Stanger, Frédéric V., Frédéric V Stanger, Tilman Schirmer, Alexander Harms (3132942), Dehio, Christoph, Harms, Alexander, Schirmer, Tilman, Christoph Dehio, Frédéric V. Stanger (585551), Alexander Harms, Tilman Schirmer (585552), Christoph Dehio (200951)   +11 more
core   +2 more sources

Reassessing the Role of the Type II MqsRA Toxin-Antitoxin System in Stress Response and Biofilm Formation: mqsA Is Transcriptionally Uncoupled from mqsR

mBio, 2019
Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin, Clothilde J. Rousseau, Nathalie Goeders, Laurence Van Melderen   +3 more
doaj   +1 more source

Toxin-antitoxin cassettes identified by TA finder in investigated Salmonella strains with functional classification of candidate toxin and antitoxin proteins.

, 2021
Toxin-antitoxin cassettes identified by TA finder in investigated Salmonella strains with functional classification of candidate toxin and antitoxin proteins.
Taruna Anand (828898), Rajesh Kumar Vaid (11302529), Bhupendra Nath Tripathi (9032255), Zoozeal Thakur (11302532), Sanjay Kumar (8853)   +4 more
core   +1 more source

A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli. [PDF]

PLoS Computational Biology, 2013
Toxin-Antitoxin modules are small operons involved in stress response and persister cell formation that encode a "toxin" and its corresponding neutralizing "antitoxin".
Lendert Gelens, Lydia Hill, Alexandra Vandervelde, Jan Danckaert, Remy Loris   +4 more
doaj   +1 more source

VapC Toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins [PDF]

, 2011
The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin modules belonging to the VapBC family. The role of these modules in the physiology of Mtb and the function(s) served by their expansion are unknown.
Mizrahi, Valerie, Bhavna G Gordhan, Vickery Arcus, Diane Kuhnert, Valerie Mizrahi, Ahidjo, Bintou Ahmadou, Kuhnert, Diane, Edith E Machowski, Machowski E.E., Joanna L. Mckenzie, Garth L. Abrahams, Kuhnert D., Machowski Edith E., Abrahams, Garth L., Ahidjo B.A., Bintou Ahmadou Ahidjo, Gordhan, Bhavna G., Arcus V., Garth L Abrahams, Abrahams G.L., Machowski, Edith E., Mizrahi V., Kuhnert Diane, Ahidjo Bintou Ahmadou, McKenzie Joanna L., Arcus Vickery, Mizrahi Valerie, Edith E. Machowski, Abrahams Garth L., Gordhan B.G., McKenzie J.L., Gordhan Bhavna G., Bhavna G, Arcus, Vickery L., Bhavna G. Gordhan, McKenzie, Joanna Leigh, Joanna L McKenzie   +36 more
core   +2 more sources

The vapB-vapC operon of Acidovorax citrulli functions as a bona-fide toxin-antitoxin module

Frontiers in Microbiology, 2016
Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific,
Reut eShavit, Mario eLebendiker, Zohar ePasternak, Saul eBurdman, Yael eHelman   +4 more
doaj   +1 more source