Results 11 to 20 of about 19,351 (174)
An oxygen-sensitive toxin–antitoxin system [PDF]
Nature Communications, 2016 Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and
Oriol Marimon +13 more
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Toxin–Antitoxin Systems in Pathogenic Bacteria [PDF]
Toxins, 2021 Toxin–antitoxin (TA) systems, which are ubiquitously present in plasmids, bacterial and archaeal genomes, are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition [...]
Juan C. Alonso
doaj +4 more sources
Chaperone addiction of toxin–antitoxin systems [PDF]
Nature Communications, 2016 Some bacterial toxin-antitoxin systems consist of a labile antitoxin that inhibits a toxin, and a chaperone that stabilizes the antitoxin. Here, Bordes et al.
Patricia Bordes +8 more
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Toxin–Antitoxin Systems in Bacillus subtilis [PDF]
Toxins, 2019 Toxin−antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afterwards found to also be widespread in bacterial chromosomes.
Sabine Brantl, Peter Müller
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Continuous Evolution System Based on Toxin-Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins. [PDF]
Adv Sci (Weinh)The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Zhang X +10 more
europepmc +2 more sources
Toxin-antitoxins and bacterial virulence [PDF]
FEMS Microbiology Reviews, 2016 Bacterial virulence relies on a delicate balance of signals interchanged between the invading microbe and the host. This communication has been extensively perceived as a battle involving harmful molecules produced by the pathogen and host defenses. In this review, we focus on a largely unexplored element of this dialogue, as are toxin-antitoxin (TA ...
Lobato-Márquez, D +2 more
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Toxin-Antitoxin Systems in Clinical Pathogens [PDF]
Toxins, 2016 Toxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Although not essential for normal cell growth, TA systems are implicated in multiple cellular functions associated with survival under stress conditions. Clinical strains of bacteria are currently causing major human health problems as a result of their multidrug resistance ...
Fernández-García, Laura +6 more
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Conditional cooperativity of toxin - antitoxin regulation can mediate bistability between growth and dormancy. [PDF]
PLoS Computational Biology, 2013 Many toxin-antitoxin operons are regulated by the toxin/antitoxin ratio by mechanisms collectively coined "conditional cooperativity". Toxin and antitoxin form heteromers with different stoichiometric ratios, and the complex with the intermediate ratio ...
Ilaria Cataudella +3 more
doaj +1 more source
Frontiers in Microbiology, 2021 The bloom-forming cyanobacterium Microcystis aeruginosa is known for its global distribution and for the production of toxic compounds. In the genome of M.
Marina Klemenčič +2 more
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Nature Communications, 2023 Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu +9 more
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