Results 111 to 120 of about 295,113 (307)
Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli [PDF]
, 2013 BACKGROUND: Bacterial toxin-antitoxin (TA) systems are formed by potent regulatory or suicide factors (toxins) and their short-lived inhibitors (antitoxins). Antitoxins are DNA-binding proteins and auto-repress transcription of TA operons.
Niilo Kaldalu +3 more
core +1 more source
Genomic Evolution of Two Acinetobacter baumannii Clinical Strains from ST-2 Clones Isolated in 2000 and 2010 (ST-2_clon_2000 and ST-2_clon_2010) [PDF]
, 2016 Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by acquiring mobile elements such as transposons, plasmids, and phages. In this study, we compared two genomes of A.
Blasco, L. +8 more
core
A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. [PDF]
PLoS ONE, 2011 Bacterial type-2 (protein-protein) toxin-antitoxin (TA) modules are two-gene operons that are thought to participate in the response to stress. Previous work with Escherichia coli has led to a debate in which some investigators conclude that the modules ...
Xiangli Wu +3 more
doaj +1 more source
The FEBS Journal, EarlyView.When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon +10 more
wiley +1 more source
Science Advances, 2020 The VapBC22 toxin-antitoxin system regulates adaptation to oxidative stress and virulence in Mycobacterium tuberculosis. Virulence-associated protein B and C toxin-antitoxin (TA) systems are widespread in prokaryotes, but their precise role in physiology
S. Agarwal +12 more
semanticscholar +1 more source
Shaping Pulses to Control Bistable Biological Systems [PDF]
, 2015 In this paper we study how to shape temporal pulses to switch a bistable system between its stable steady states. Our motivation for pulse-based control comes from applications in synthetic biology, where it is generally difficult to implement real-time ...
Angeli, David +3 more
core +2 more sources
Rapid curtailing of the stringent response by toxin-antitoxin module-encoded mRNases [PDF]
, 2016 Escherichia coli regulates its metabolism to adapt to changes in the environment, in particular to stressful downshifts in nutrient quality. Such shifts elicit the so-called stringent response, coordinated by the alarmone guanosine tetra- and ...
Tian, Chengzhe +6 more
core +2 more sources
mBioToxin-antitoxin (TA) modules represent genetic elements implicated in bacterial persistence. Mycobacterium tuberculosis encodes 90+ TA modules, the majority of which are type II, comprising of a toxin component and an antitoxin counterpart that ...
Shafinaz Rahman Sarah +6 more
doaj +1 more source
Medical and Veterinary Entomology, EarlyView.The fitness of Anopheles coluzzii mosquito lines (VK strain) selected for early and late egg hatching was compared with each other and a reference strain (Mopti). There was an observed increase in fitness in fecundity and survival among the late‐hatching lines, but no negative effects of selection on fecundity and adult survival were detected.
Emmanuel C. Ottih +3 more
wiley +1 more source
mBio, 2018 Persistence is a reversible and low-frequency phenomenon allowing a subpopulation of a clonal bacterial population to survive antibiotic treatments. Upon removal of the antibiotic, persister cells resume growth and give rise to viable progeny.
F. Goormaghtigh +11 more
semanticscholar +1 more source