IntroductionThe stringent response is one of the fundamental mechanisms that control and modulate bacterial adaptation to stress conditions, such as nutrient limitation.
Monika Maciąg-Dorszyńska +3 more
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Made Rai Dwitya Wiradiputra,1,2 Piyatip Khuntayaporn,1,3 Krit Thirapanmethee,1,3 Mullika Traidej Chomnawang1,3 1Antimicrobial Resistance Interdisciplinary Group (AmRIG), Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Biopharmaceutical ...
Wiradiputra MRD +3 more
doaj
Regulating Toxin-Antitoxin Expression: Controlled Detonation of Intracellular Molecular Timebombs
Genes for toxin-antitoxin (TA) complexes are widely disseminated in bacteria, including in pathogenic and antibiotic resistant species. The toxins are liberated from association with the cognate antitoxins by certain physiological triggers to impair ...
Finbarr Hayes, Barbara Kędzierska
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Structural and functional studies of theMycobacterium tuberculosisVapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides [PDF]
In-Gyun Lee +5 more
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Coupling immunity and programmed cell suicide in prokaryotes: Life-or-death choices [PDF]
Host-pathogen arms race is a universal, central aspect of the evolution of life. Most organisms evolved several distinct yet interacting strategies of anti-pathogen defense including resistance to parasite invasion, innate and adaptive immunity, and ...
Abudayyeh +94 more
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Chromosomal toxin-antitoxin systems in Pseudomonas putida are rather selfish than beneficial [PDF]
Sirli Rosendahl +4 more
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Molecular bases and role of viruses in the human microbiome. [PDF]
Viruses are dependent biological entities that interact with the genetic material of most cells on the planet, including the trillions within the human microbiome.
Abeles, Shira R, Pride, David T
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A method for the screening of tetanus and diphtheria antibodies in serum using anatoxin (inactivated toxin) instead of toxin was developed as an alternative to the in vivo toxin neutralization assay based on the toxin-binding inhibition test (TOBI test).
M.H. Sonobe +8 more
doaj
Analysis of virus genomes from glacial environments reveals novel virus groups with unusual host interactions [PDF]
Microbial communities in glacial ecosystems are diverse, active, and subjected to strong viral pressures and infection rates. In this study we analyse putative virus genomes assembled from three dsDNA viromes from cryoconite hole ecosystems of Svalbard ...
Anesio, Alexandre M B +2 more
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The crystal structure of the Rv0301‐Rv0300 VapBC‐3 toxin—antitoxin complex from M. tuberculosis reveals a Mg2+ ion in the active site and a putative RNA‐binding site [PDF]
Andrew Min +5 more
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