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Toxin-Antitoxin Battle in Bacteria

, 2013
This PhD thesis consists of three research projects revolving around the common thread of investigation of the properties and biological functions of Toxin-Antitoxin loci.
Cataudella, Ilaria
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Type II Toxin-Antitoxin Systems in Escherichia coli [PDF]

He Zhang,1 Shuan Tao,2 Huimin Chen,2 Yewei Fang,2 Yao Xu,3 A-Xiang Han,2 Fang Ma,1,* Wei Liang2,* 1Department of Medical Laboratory, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Clinical Laboratory, The ...
Fang Y, Han AX, Liang W, Zhang H, Tao S, Chen H, Ma F, Xu Y   +7 more
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On the Danysz Effect with reference to the Toxin-antitoxin Reaction [PDF]

Journal of Hygiene, 1907
Svante Arrhenius (1908) has taken exception to my criticism (1907) of his interpretation of the Danysz Effect with reference to the Toxin-Antitoxin reaction. In this paper he has given an interesting but rather far-fetched analogy to the Danysz Effect, which is, according to him, purely chemical in character and subject to the laws of chemical mass ...
openaire   +4 more sources

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS

, 2012
International audienceAmong bacterial toxin-antitoxin systems, to date no antitoxin has been identified that functions by cleaving toxin mRNA. Here we show that YjdO (renamed GhoT) is a membrane lytic peptide that causes ghost cell formation (lysed cells
Wolfgang Peti, Zheng, Kevin, Rebecca Page, Hsin-Yao Cheng, Torsten Herrmann, Xiaoxue Wang, Devon O Osbourne, Michael J Benedik, Cecilia Quiroga, Viviana Sanchez-Torres, Seok Hoon Hong, Kevin Zheng, Wang, Xiaoxue, Sanchez-Torres, Viviana, Thomas K Wood, Lord, Dana M, Benedik, Michael J, Cheng, Hsin-Yao, Quiroga, Cecilia, Wood, Thomas K, Peti, Wolfgang, Herrmann, Torsten, Dana M Lord, Page, Rebecca, Hong, Seok Hoon, Osbourne, Devon O   +25 more
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Antibiotic-induced degradation of antitoxin enhances the transcription of acetyltransferase-type toxin-antitoxin operon

, 2023
Bacterial toxin-antitoxin (TA) modules respond to various stressful conditions. The Gcn5-related N-acetyltransferase-type toxin (GNAT) protein encoded by the GNAT-RHH TA locus is involved in the antibiotic tolerance of Klebsiella pneumoniae.M215 ...
Tai, Cui, Chen, Zhaoyan, Đorđević, Marko, Li, Peifei, Ilic, Bojana, Goh, Ying-Xian, Ou, Hong-Yu, Deng, Zixin   +7 more
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Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems

Frontiers in Molecular Biosciences, 2016
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan, Manuel eEspinosa, Chew Chieng eYeo   +2 more
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Toxin-Antitoxin Systems: A Key Role on Persister Formation in Salmonella enterica Serovar Typhimurium

Infection and Drug Resistance, 2022
Made Rai Dwitya Wiradiputra,1,2 Piyatip Khuntayaporn,1,3 Krit Thirapanmethee,1,3 Mullika Traidej Chomnawang1,3 1Antimicrobial Resistance Interdisciplinary Group (AmRIG), Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Biopharmaceutical ...
Wiradiputra MRD, Khuntayaporn P, Thirapanmethee K, Chomnawang MT   +3 more
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Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism.

PLoS Genetics, 2012
Abortive infection, during which an infected bacterial cell commits altruistic suicide to destroy the replicating bacteriophage and protect the clonal population, can be mediated by toxin-antitoxin systems such as the Type III protein-RNA toxin-antitoxin
Tim R Blower, Terry J Evans, Rita Przybilski, Peter C Fineran, George P C Salmond   +4 more
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Toxin-antitoxin genes are differentially expressed in Escherichia coli relA and spoT mutans cultured under nitrogen, fatty acid, or carbon starvation conditions

Frontiers in Microbiology
IntroductionThe stringent response is one of the fundamental mechanisms that control and modulate bacterial adaptation to stress conditions, such as nutrient limitation.
Monika Maciąg-Dorszyńska, Paweł Olszewski, Monika Karczewska, Lidia Boss   +3 more
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Determination of low tetanus or diphtheria antitoxin titers in sera by a toxin neutralization assay and a modified toxin-binding inhibition test

Brazilian Journal of Medical and Biological Research, 2007
A method for the screening of tetanus and diphtheria antibodies in serum using anatoxin (inactivated toxin) instead of toxin was developed as an alternative to the in vivo toxin neutralization assay based on the toxin-binding inhibition test (TOBI test).
M.H. Sonobe, A.G. Trezena, F.B. Guilhen, V.L. Takano, F. Fratelli, D. Sakauchi, J.F. Morais, S.M.A. Prado, H.G. Higashi   +8 more
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