Results 81 to 90 of about 144,728 (208)

A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. [PDF]

PLoS ONE, 2011
Bacterial type-2 (protein-protein) toxin-antitoxin (TA) modules are two-gene operons that are thought to participate in the response to stress. Previous work with Escherichia coli has led to a debate in which some investigators conclude that the modules ...
Xiangli Wu, Xiuhong Wang, Karl Drlica, Xilin Zhao   +3 more
doaj   +1 more source

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino, Paolo Grieco, Francesco Merlino   +2 more
wiley   +1 more source

The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation

Microorganisms
Toxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo, Deborah Kohn Damiano, Aline Florencio Teixeira, Ana Lucia Tabet Oller Nascimento, Luis Guilherme Virgilio Fernandes, Alexandre Paulo Yague Lopes   +5 more
doaj   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, Volume 13, Issue 46, 17 August 2026.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Higher-Order Structure in Bacterial VapBC Toxin-Antitoxin Complexes

, 2017
Toxin-antitoxin systems are widespread in the bacterial kingdom, including in pathogenic species, where they allow rapid adaptation to changing environmental conditions through selective inhibition of key cellular processes, such as DNA replication or ...
Brodersen, Ditlev E, Ditlev E. Brodersen, Bendtsen, Kirstine L, Kirstine L. Bendtsen   +3 more
core   +1 more source

Dietary Terpenoids in Advancing Biofilm‐Mediated Cancer Prevention: Antibiofilm Cascade, Molecular Crosstalk, and Nano‐Facilitated Functional Delivery

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT The role of microbes in cancer is gaining attention these days, especially in the context of tumor‐associated biofilms and dysbiotic microbiota. Biofilm‐producing microorganisms, such as Fusobacterium nucleatum and Helicobacter pylori, trigger oncogenic inflammation and immune evasion in tumor initiation and progression, and in the development
Saikat Mazumder, Aditi Dey, Debasmita Bhattacharya, Dibyajit Lahiri, Moupriya Nag, Sudhriti Maity, Navin Kumar, Soumya Pandit, Vaseem Raja, Shubham Sharma, Shashi Prakash Dwivedi, Mithul Rajeev, Juwita Ratna Dewi, Lola Sanayeva, Dilbar Azimova   +14 more
wiley   +1 more source

conformational changes of antitoxin HigA by binding of toxin HigB

, 2021
학위논문(박사)--아주대학교 일반대학원 :분자과학기술학과,2021. 2General Introduction 1 Shigella flexneri 1 Persistent cells and toxin-antitoxin system 2 Multidrug resistance and multidrug tolerance 5 Six types of toxin-antitoxin system 7 Conditional cooperativity 10 Chapter
윤원수
core  

de novo synthesis of a bacterial toxin/antitoxin system [PDF]

, 2014
The prevalence of toxin/antitoxin (TA) systems in almost all genomes suggests they evolve rapidly. Here we show that an antitoxin from a type V system (GhoS, an endoribonuclease specific for the mRNA of the toxin GhoT) can be converted into a novel toxin
Soo, Valerie WC, Cheng, Hsin-Yao, Wood, Thomas K, Kwan, Brian W   +3 more
core   +1 more source

Silk Fibroin‐Modified Titanium Implants for Bone Tissue Engineering: Structural Basis, Functionalization and Composite Strategies

Macromolecular Bioscience, Volume 26, Issue 8, August 2026.
Silk fibroin coatings transform inert 3D‐printed porous titanium scaffolds into intelligent, bioactive implants. Leveraging its pH‐responsive structure and tunable degradation, silk fibroin enables spatiotemporal drug delivery, promotes osteoblast activity, and modulates macrophage immunity.
Jiajun Liu, Yan Wang, Xin Li, Guang Li, Zexin Zheng, Lu Zhang, Xiaotian Feng, Tiancheng Ma, Yujing Chen, Yanxin Li, Yibo Liu, Benchao Dong, Peichuan Yang, Yan Li, Mengran Qin, Jianxiong Ma   +15 more
wiley   +1 more source

Toxin-Antitoxin Systems: Classification, Biological Function and Application in Biotechnology

, 2013
The toxin-antitoxin (TA) systems are systems in which an unstable antitoxin inhibits a stable toxin. This review aims to introduce the TA system and its biological application in bacteria. For this purpose, first we introduce a new classification for the
Sobhan Ghafourian, Mohammad Raftari, Nourkhoda Sadeghifard, Zamberi Sekawi   +3 more
core   +1 more source