Results 11 to 20 of about 295,113 (307)

Modeling sRNA-Regulated Plasmid Maintenance. [PDF]

PLoS ONE, 2017
We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj   +4 more sources

Toxin–Antitoxin Systems in Pathogenic Bacteria [PDF]

Toxins, 2021
Toxin–antitoxin (TA) systems, which are ubiquitously present in plasmids, bacterial and archaeal genomes, are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition [...]
Juan C. Alonso
doaj   +4 more sources

Toxin-Antitoxin Systems of Staphylococcus aureus [PDF]

Toxins, 2016
Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins.
Bertram, R, Schuster, CF
core   +10 more sources

An oxygen-sensitive toxin–antitoxin system [PDF]

Nature Communications, 2016
Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and
Oriol Marimon, João M. C. Teixeira, Tiago N. Cordeiro, Valerie W. C. Soo, Thammajun L. Wood, Maxim Mayzel, Irene Amata, Jesús García, Ainara Morera, Marina Gay, Marta Vilaseca, Vladislav Yu Orekhov, Thomas K. Wood, Miquel Pons   +13 more
doaj   +8 more sources

Chaperone addiction of toxin–antitoxin systems [PDF]

Nature Communications, 2016
Some bacterial toxin-antitoxin systems consist of a labile antitoxin that inhibits a toxin, and a chaperone that stabilizes the antitoxin. Here, Bordes et al.
Patricia Bordes, Ambre Julie Sala, Sara Ayala, Pauline Texier, Nawel Slama, Anne-Marie Cirinesi, Valérie Guillet, Lionel Mourey, Pierre Genevaux   +8 more
doaj   +3 more sources

Structure, Evolution, and Functions of Bacterial Type III Toxin-Antitoxin Systems [PDF]

Toxins, 2016
Toxin-antitoxin (TA) systems are small genetic modules that encode a toxin (that targets an essential cellular process) and an antitoxin that neutralises or suppresses the deleterious effect of the toxin.
Nathalie Goeders, Ray Chai, Bihe Chen, Andrew Day, George P. C. Salmond   +4 more
doaj   +9 more sources

Toxin–Antitoxin Systems in Bacillus subtilis [PDF]

Toxins, 2019
Toxin−antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afterwards found to also be widespread in bacterial chromosomes.
Sabine Brantl, Peter Müller
doaj   +3 more sources

TASmania: A bacterial Toxin-Antitoxin Systems database [PDF]

PLOS Computational Biology, 2019
Bacterial Toxin-Antitoxin systems (TAS) are involved in key biological functions including plasmid maintenance, defense against phages, persistence and virulence.
H. Akarsu, P. Bordes, Moise Mansour, Donna-Joe Bigot, P. Genevaux, L. Falquet   +5 more
semanticscholar   +5 more sources

Toxin-antitoxin systems in bacterial pathogenesis.

Heliyon, 2023
Toxin-Antitoxin (TA) systems are abundant in prokaryotes and play an important role in various biological processes such as plasmid maintenance, phage inhibition, stress response, biofilm formation, and dormant persister cell generation. TA loci are abundant in pathogenic intracellular micro-organisms and help in their adaptation to the harsh host ...
Sonika Sonika, Samer Singh, Saurabh Mishra, Shashikala Verma   +3 more
semanticscholar   +4 more sources

Toxin-Antitoxin Systems as Multilevel Interaction Systems [PDF]

Toxins, 2014
Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an antitoxin counteracting the activity of the toxic protein. These systems are widely spread in bacterial and archaeal genomes.
Nathalie Goeders, Laurence Van Melderen
doaj   +5 more sources