Results 21 to 30 of about 295,113 (307)
Diphtheria Toxin-Antitoxin and Toxoid
American Journal of Public Health and the Nations Health, 1932 William H. Park, M. Carl Schroder
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THE NATURE OF THE TOXIN-ANTITOXIN FLOCCULATION PHENOMENON [PDF]
Journal of Experimental Medicine, 1926 1. Animals immunized with the formalinized filtrates of young toxic cultures of B. botulinus produce an antitoxic serum poor in precipitins. 2. Animals immunized with the formalinized filtrates of old and partly autolyzed toxic cultures produce an antitoxic serum containing precipitins. 3. Animals immunized with toxin-free
J. Bronfenbrenner, P Reichert
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Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Toxin–antitoxin systems are enigmatic components of microbial genomes, with their biological functions being a conundrum of debate for decades. Increasingly, TAs are being found to have a role in defense against bacteriophages.
K. Ernits +21 more
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Bio-Protocol, 2023 Toxin–antitoxin (TA) systems are widespread bacterial immune systems that confer protection against various environmental stresses. TA systems have been classified into eight types (I–VIII) based on the nature and mechanism of action of the antitoxin ...
Parthasarathy Manikandan +2 more
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Toxin-Antitoxin Pairs in Bacteria [PDF]
Cell, 2003 Plasmid toxin-antitoxin systems, which kill daughter cells that fail to inherit the plasmid genome, have chromosomal homologs in eubacteria and archaea. In this issue of Cell, Pederson et al. show that the E. coli RelE toxin cleaves mRNA in the ribosomal A site, potentially allowing it to function as a stress regulator during amino acid starvation.
Christopher S. Hayes, Robert T. Sauer
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mBio, 2021 Bacterial toxin-antitoxin (TA) systems encode a toxin and an antitoxin that counteracts the toxin. Such TA systems are found abundantly on bacterial chromosomes and on extrachromosomal genetic elements. The toxin is always a protein.
Alexander Mager +2 more
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Toxin-antitoxins and bacterial virulence [PDF]
FEMS Microbiology Reviews, 2016 Bacterial virulence relies on a delicate balance of signals interchanged between the invading microbe and the host. This communication has been extensively perceived as a battle involving harmful molecules produced by the pathogen and host defenses. In this review, we focus on a largely unexplored element of this dialogue, as are toxin-antitoxin (TA ...
Lobato-Márquez, D +2 more
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Frontiers in Genetics, 2021 Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra +2 more
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Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems
Nature, 2022 Retrons are prokaryotic genetic retroelements encoding a reverse transcriptase that produces multi-copy single-stranded DNA1 (msDNA). Despite decades of research on the biosynthesis of msDNA2, the function and physiological roles of retrons have remained
Jacob Bobonis +19 more
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Journal of Bacteriology, 2022 M. tuberculosis harbors a large number of type II toxin-antitoxin (TA) systems, the exact roles for most of which are unclear. Prior studies have reported that overexpression of several of these type II toxins inhibits bacterial growth and contributes to
Gopinath Chattopadhyay +9 more
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