Toxin-antitoxin system - Open Access .click

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The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

Microorganisms
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano +6 more
doaj +1 more source

Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system [PDF]

, 2018
Nela Nikolić
openalex +1 more source

Intracellular Localization of the Proteins Encoded by Some Type II Toxin-Antitoxin Systems in Escherichia coli

, 2021
Alexander Mager, Tommy Safran, Hanna Engelberg–Kulka +2 more
openalex +1 more source

The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis

Nature Communications, 2018
Toxin–antitoxin (TA) systems are important modulators of bacterial physiology. Here, the authors structurally characterize the epsilon/zeta TA system from the Gram-negative pathogen Neisseria gonorrhoeae and show that the toxin interferes with ...
Andrea Rocker +5 more
doaj +1 more source

Novel Single-Cell Method for Studying Toxin-Antitoxin Systems [PDF]

, 2016
细菌的抗药性危害日益严重，毒素－抗毒素（TA）系统在细菌内的异质性表达是多药耐受性存留细胞形成的重要原因。阐明致病菌中毒素－抗毒素系统的作用机理和生理功能对研发防控致病菌的新策略和疾病诊断治疗等具有重要意义。目前，对TA系统的研究主要集中在基因水平或转录水平，而传统基于蛋白质水平的检测方法，如WesternBlot等都是对大量细菌裂解液中的毒素抗毒素蛋白进行检测，是大量细菌内毒素抗毒素蛋白表现的集权平均。对单细菌水平的毒素－抗毒素蛋白进行快速逐一分析可揭示因集权平均而被掩盖的个体差异 ...
宋毅怡
core

Druggability of bacterial toxins-antitoxins [PDF]

, 2015
53 p.-8 fig.-3 tab.Type II (proteic) toxin-antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene.
Balsa, Dolors, Chan, Wai Ting, Espinosa, Manuel +2 more
core

Caracterização da interação HipAB na Shewanella oneidensis MR1 [PDF]

, 2013
Mestrado em BioquímicaBacterial resistance is a major issue in research related to environmental and public health, due to the ineffectiveness of antibiotics, resulting from a subpopulation of bacterial cells entering a dormant state.
Henriques, Andreia Filipa Pereira
core

Reassessing the Role of Type II Toxin-Antitoxin Systems in Formation of Escherichia coli Type II Persister Cells [PDF]