Results 131 to 140 of about 28,880 (211)

Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system [PDF]

The astounding number of anti-phage defenses encoded by bacteria is countered by an elaborate set of phage counter-defenses, though their evolutionary origins are often unknown. Here, we report the discovery of an orphan antitoxin counter-defense element
Johannesman, Anna, Carlson, Nico, Awasthi, Leila C, LeRoux, Michele   +3 more
core   +2 more sources

The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

Microorganisms
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano, Bruna O. P. Azevedo, George S. C. Fernandes, Aline F. Teixeira, Viviane M. Gonçalves, Ana L. T. O. Nascimento, Alexandre P. Y. Lopes   +6 more
doaj   +1 more source

The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis

Nature Communications, 2018
Toxin–antitoxin (TA) systems are important modulators of bacterial physiology. Here, the authors structurally characterize the epsilon/zeta TA system from the Gram-negative pathogen Neisseria gonorrhoeae and show that the toxin interferes with ...
Andrea Rocker, Madeleine Peschke, Tiia Kittilä, Roman Sakson, Clara Brieke, Anton Meinhart   +5 more
doaj   +1 more source

Toxin Inactivation in Toxin/Antitoxin Systems

, 2019
Toxin/antitoxin (TA) systems are used primarily to inhibit phage, reduce metabolic activity during stress, and maintain genetic elements. Given the extreme toxicity of some of the toxins of these TA systems, we were curious how the cell silences toxins, if the antitoxin is inactivated or when toxins are obtained without antitoxins via horizontal gene ...
Laura Fernandez-Garcia, Jun-Seob Kim, Maria Tomas, Thomas K. Wood   +3 more
openaire   +2 more sources

Kinetic simulations of selected toxin-antitoxin modules [PDF]

Moduli toksin-antitoksin so manjši genetski sistemi, ki so množično prisotni v genomih bakterij in arhej. Najpogosteje zaporedje vsebuje zapis za proteina toksin in antitoksin, ter operatorsko regijo, preko katere se uravnava nivo izražanja obeh ...
Urbič, Zala
core  

Novel type II toxin-antitoxin systems with VapD-like proteins

mBio
Type II toxin-antitoxin (TA) systems are widespread in prokaryotes. They consist of neighboring genes encoding two small proteins: a toxin that inhibits a critical cellular process and an antitoxin that binds to and neutralizes the toxin.
Konstantin Gilep, Dmitry Bikmetov, Aleksandr Popov, Anastasiia Rusanova, Shunsuke Tagami, Svetlana Dubiley, Konstantin Severinov   +6 more
doaj   +1 more source

Toxin antitoxin system as an antimicrobial target for antibiotic resistant staphylococcus aureus [PDF]

, 2014
Antibiotic-resistant bacteria have become a global concern and new strategies to control pathogenic bacteria are urgently needed. Toxin antitoxin (TA) system is defined as a regulator system consist of toxin that neutralized by cognate antitoxin.
Ghafouryan, Sobhan
core  

Structural and functional characterization of VapBC52 toxin-antitoxin system from Mycobacterium tuberculosis. [PDF]

Nucleic Acids Res
Singh M, Singh C, Nair AV, Ahmad I, Sharma A, Bhasin M, Jain V, Singh R, Thakur KG.   +8 more
europepmc   +1 more source

The endogenous Coxiella burnetii plasmid encodes a functional toxin-antitoxin system. [PDF]

Mol Microbiol, 2022
Wachter S, Cockrell DC, Miller HE, Virtaneva K, Kanakabandi K, Darwitz B, Heinzen RA, Beare PA.   +7 more
europepmc   +1 more source

Ribosomal RNA cleavage by the previously unidentified RelS-RelI toxin-antitoxin system controls growth of Mycobacterium tuberculosis. [PDF]

Nucleic Acids Res
Han X, Arrowsmith TJ, Karamycheva S, Xu X, Coddeville M, Pagès C, Voisin B, Gutierrez C, Neyrolles O, Makarova KS, Blower TR, Genevaux P.   +11 more
europepmc   +1 more source