Evolution of the SpoIISABC Toxin-Antitoxin-Antitoxin System in Bacilli
Toxins, 2016 Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIISABC system, originally identified in Bacillus subtilis, consists of three components: a SpoIISA toxin and the SpoIISB and SpoIISC antitoxins ...
Marek Gabriško, Imrich Barák
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PLoS ONE, 2012 Bacterial toxin-antitoxin (TA) systems encode two proteins, a potent inhibitor of cell proliferation (toxin) and its specific antidote (antitoxin). Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase ...
Andrew B Smith +8 more
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Stabilization of the Virulence Plasmid pSLT of Salmonella Typhimurium by Three Maintenance Systems and Its Evaluation by Using a New Stability Test [PDF]
, 2016 Certain Salmonella enterica serovars belonging to subspecies I carry low-copy-number virulence plasmids of variable size (50–90 kb). All of these plasmids share the spv operon, which is important for systemic infection.
Díaz-Orejas, Ramón +4 more
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Identification and characterisation of toxin-antitoxin systems (TA) in Burkholderia pseudomallei [PDF]
, 2013 The aim of this study was to identify and characterise type II toxin-antitoxin (TA) systems in Burkholderia pseudomallei, the causative agent of the human disease melioidosis. 8 putative TA systems were identified within the genome of B. pseudomallei
Butt, Aaron Trevor
core
Bacterial Toxin–Antitoxin Systems: More Than Selfish Entities?
PLoS Genetics, 2009 Bacterial toxin-antitoxin (TA) systems are diverse and widespread in the prokaryotic kingdom. They are composed of closely linked genes encoding a stable toxin that can harm the host cell and its cognate labile antitoxin, which protects the host from the toxin's deleterious effect.
Van Melderen, Laurence +1 more
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Resonant activation: a strategy against bacterial persistence
, 2010 A bacterial colony may develop a small number of cells genetically identical to, but phenotypically different from other normally growing bacteria. These so-called persister cells keep themselves in a dormant state and thus are insensitive to antibiotic ...
Hanggi P +4 more
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Toxin Inactivation in Toxin/Antitoxin Systems
, 2019 Toxin/antitoxin (TA) systems are used primarily to inhibit phage, reduce metabolic activity during stress, and maintain genetic elements. Given the extreme toxicity of some of the toxins of these TA systems, we were curious how the cell silences toxins, if the antitoxin is inactivated or when toxins are obtained without antitoxins via horizontal gene ...
Laura Fernandez-Garcia +3 more
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Genomic Evolution of Two Acinetobacter baumannii Clinical Strains from ST-2 Clones Isolated in 2000 and 2010 (ST-2_clon_2000 and ST-2_clon_2010) [PDF]
, 2016 Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by acquiring mobile elements such as transposons, plasmids, and phages. In this study, we compared two genomes of A.
Blasco, L. +8 more
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The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation [PDF]
, 2014 © 2014 The Authors Journal compilation. ©2014 Biochemical Society.This is an open access article that is freely available in ORE or from the publisher's website.
Aaron Butt +62 more
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ESBL-plasmids carrying toxin-antitoxin systems can be “cured” of wild-type Escherichia coli using a heat technique [PDF]
, 2013 Plasmid-encoded extended-spectrum beta-lactamase (ESBL)-enzymes are frequently produced by Escherichia coli. Several ESBL-plasmids contain genes for toxin- antitoxin (TA) systems, which assure the maintenance of plasmids in bacteria and prevent the ...
Ewers, Christa +4 more
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