Results 111 to 120 of about 17,352,598 (197)

Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems

Frontiers in Molecular Biosciences, 2016
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan, Manuel eEspinosa, Chew Chieng eYeo   +2 more
doaj   +1 more source

Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa

Microbial Biotechnology, 2020
Pf prophages are ssDNA filamentous prophages that are prevalent among various Pseudomonas aeruginosa strains. The genomes of Pf prophages contain not only core genes encoding functions involved in phage replication, structure and assembly but also ...
Yang-Mei Li, Xiaoxiao Liu, Kai-Hao Tang, Wei-Quan Wang, Yun-Xue Guo, Xiao-Xue Wang   +5 more
semanticscholar   +1 more source

The 3D genome of Gigaspora margarita unveils stable chromatin and nucleolar organization and symbiont‐dependent genome dynamics

New Phytologist, Volume 251, Issue 5, Page 2799-2817, September 2026.
Summary Arbuscular mycorrhizal fungi (AMF) are widespread plant symbionts that enhance nutrient acquisition and influence ecosystem productivity. Previous chromosome‐level assemblies of the model species Rhizophagus irregularis revealed a two‐compartment genome architecture (active A and repressed B chromatin compartments), yet its conservation across ...
Ken Mugambi, Jordana Oliveira, Franco Magurno, Alessandra Salvioli di Fossalunga, Mara Novero, Luisa Lanfranco, Stefano Ghignone, Gökalp Yildirir, Yan Wang, Paola Bonfante, Nicolas Corradi   +10 more
wiley   +1 more source

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino, Paolo Grieco, Francesco Merlino   +2 more
wiley   +1 more source

Stress induces the transcription of toxin-antitoxin systems but does not activate toxin

, 2021
Data corresponding to manuscript entitled "Stress induces the transcription of toxin-antitoxin systems but does not activate ...
LeRoux, M (via Mendeley Data)
core   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, Volume 13, Issue 46, 17 August 2026.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae

, 2010
The pneumococcal epsilon zeta antitoxin toxin (PezAT) system is a chromosomally encoded, class II toxin antitoxin system from the human pathogen Streptococcus pneumnoniae.
Mutschler, H., Reinstein, J., Meinhart, A.   +2 more
core   +1 more source

Toxin-Antitoxin Battle in Bacteria

, 2013
This PhD thesis consists of three research projects revolving around the common thread of investigation of the properties and biological functions of Toxin-Antitoxin loci.
Cataudella, Ilaria
core   +1 more source

Identification and characterization of a toxin-antitoxin system in the pVir plasmid of Campylobacter jejuni [PDF]

, 2011
Toxin-antitoxin systems are prevalent in different bacterial organisms and are encoded in the chromosomal or plasmid DNA. The primary function of a plasmid toxin-antitoxin module is to stabilize the plasmid by eliminating plasmid-free daughter cells ...
Patil, Rocky
core   +1 more source

Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation

npj Systems Biology and Applications
Antibiotic persistence, characterized by a dormant subpopulation of bacterial cells that causes chronic and recurrent infections, remains poorly understood despite being recognized nearly a century ago. Toxin–antitoxin (TA) systems, which include a toxin
Sofija Markovic, Magdalena Djordjevic, Hong-Yu OU, Marko Djordjevic   +3 more
doaj   +1 more source