Results 91 to 100 of about 23,162 (212)
Control of Toxin-Antitoxin Systems by Proteases in Mycobacterium Tuberculosis
Frontiers in Molecular Biosciences, 2021 Toxin-antitoxin (TA) systems are small genetic elements composed of a noxious toxin and a counteracting cognate antitoxin. Although they are widespread in bacterial chromosomes and in mobile genetic elements, their cellular functions and activation ...
Patricia Bordes, Pierre Genevaux
doaj +1 more source
Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315 [PDF]
, 2015 Background: Burkholderia cenocepacia is a soil-dwelling Gram-negative Betaproteobacterium with an important role as opportunistic pathogen in humans. Infections with B.
Coenye, Tom +6 more
core +2 more sources
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley +1 more source
Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. [PDF]
PLoS ONE, 2010 RelBE represents a typical bacterial toxin-antitoxin (TA) system. Mycobacterium tuberculosis H37Rv, the pathogen responsible for human tuberculosis, contains three RelBE-like modules, RelBE, RelFG, and RelJK, which are at least partly expressed in human ...
Min Yang +4 more
doaj +1 more source
Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence [PDF]
, 2014 A newly recognized Serratia species, termed South African Caenorhabditis briggsae isolate (SCBI), is both a mutualist of the nematode Caenorhabditis briggsae KT0001 and a pathogen of lepidopteran insects. Serratia sp.
Petersen, Lauren M., Tisa, Louis S.
core +2 more sources
Acta Paediatrica, EarlyView.ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad +6 more
wiley +1 more source
Type II Toxin-Antitoxin Systems and Persister Cells
mBio, 2018 Last year, Gerdes and colleagues published a paper (1) describing experiments that failed to support earlier work from their group (2, 3) which had implicated 10 type II toxin-antitoxin (TA) systems in the formation of antibiotic-tolerant Escherichia coli K-12 persister cells.
Holden, DW, Errington, J
openaire +5 more sources
An SOS-Regulated Type 2 Toxin-Antitoxin System [PDF]
Journal of Bacteriology, 2009 ABSTRACTTheEscherichia colichromosome encodes seven demonstrated type 2 toxin-antitoxin (TA) systems: cassettes of two or three cotranscribed genes, one encoding a stable toxin protein that can cause cell stasis or death, another encoding a labile antitoxin protein, and sometimes a third regulatory protein.
Larissa A, Singletary +6 more
openaire +2 more sources
MicroorganismsToxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo +5 more
doaj +1 more source
The bacterial Type III toxin-antitoxin system, ToxIN, is a dynamic protein-RNA complex with stability-dependent antiviral abortive infection activity. [PDF]
, 2018 Bacteria have evolved numerous defense systems to protect themselves from viral (bacteriophage) infection. The ToxIN system of Pectobacterium atrosepticum is a Type III toxin-antitoxin complex and "altruistic suicide" anti-phage system, which kills phage-
Akusobi, Chidiebere +3 more
core +2 more sources