Results 91 to 100 of about 13,696 (172)

A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions.

PLoS ONE, 2012
Bacterial toxin-antitoxin (TA) systems encode two proteins, a potent inhibitor of cell proliferation (toxin) and its specific antidote (antitoxin). Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase ...
Andrew B Smith, Juan López-Villarejo, Elizabeth Diago-Navarro, Lesley A Mitchenall, Arjan Barendregt, Albert J Heck, Marc Lemonnier, Anthony Maxwell, Ramón Díaz-Orejas   +8 more
doaj   +1 more source

Insights into toxin-antitoxin systems in the genus Bifidobacterium

Applied and Environmental Microbiology
ABSTRACT Toxin-antitoxin (TA) systems are widespread genetic modules in prokaryotes, implicated in diverse functions including stress adaptation, genome stability, and virulence. While extensively studied in pathogenic bacteria, their presence and roles in beneficial gut
Claudia Lefimil, Paula Bustamante
openaire   +2 more sources

Development of an antibiotic marker-free platform for heterologous protein production in Streptomyces

Microbial Cell Factories, 2017
Background The industrial use of enzymes produced by microorganisms is continuously growing due to the need for sustainable solutions. Nevertheless, many of the plasmids used for recombinant production of proteins in bacteria are based on the use of ...
Laura Sevillano, Margarita Díaz, Ramón I. Santamaría   +2 more
doaj   +1 more source

The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

Microorganisms
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano, Bruna O. P. Azevedo, George S. C. Fernandes, Aline F. Teixeira, Viviane M. Gonçalves, Ana L. T. O. Nascimento, Alexandre P. Y. Lopes   +6 more
doaj   +1 more source

Algal blooms as biofilm analogues: Evolutionary insights into cyanobacterial adaptation

Limnology and Oceanography Letters, Volume 11, Issue 3, May 2026.
Hidetoshi Urakawa, Hans W. Paerl
wiley   +1 more source

The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis

Nature Communications, 2018
Toxin–antitoxin (TA) systems are important modulators of bacterial physiology. Here, the authors structurally characterize the epsilon/zeta TA system from the Gram-negative pathogen Neisseria gonorrhoeae and show that the toxin interferes with ...
Andrea Rocker, Madeleine Peschke, Tiia Kittilä, Roman Sakson, Clara Brieke, Anton Meinhart   +5 more
doaj   +1 more source

Toxin Inactivation in Toxin/Antitoxin Systems

, 2019
Toxin/antitoxin (TA) systems are used primarily to inhibit phage, reduce metabolic activity during stress, and maintain genetic elements. Given the extreme toxicity of some of the toxins of these TA systems, we were curious how the cell silences toxins, if the antitoxin is inactivated or when toxins are obtained without antitoxins via horizontal gene ...
Laura Fernandez-Garcia, Jun-Seob Kim, Maria Tomas, Thomas K. Wood   +3 more
openaire   +2 more sources

Novel type II toxin-antitoxin systems with VapD-like proteins

mBio
Type II toxin-antitoxin (TA) systems are widespread in prokaryotes. They consist of neighboring genes encoding two small proteins: a toxin that inhibits a critical cellular process and an antitoxin that binds to and neutralizes the toxin.
Konstantin Gilep, Dmitry Bikmetov, Aleksandr Popov, Anastasiia Rusanova, Shunsuke Tagami, Svetlana Dubiley, Konstantin Severinov   +6 more
doaj   +1 more source

Type II Toxin-Antitoxin Systems in Escherichia coli

Infection and Drug Resistance
The toxin-antitoxin (TA) system is widespread in prokaryotes and archaea, comprising toxins and antitoxins that counterbalance each other. Based on the nature and mode of action of antitoxins, they are classified into eight groups (type I to VIII). Both the toxins and the antitoxins are proteins in type II TA systems, and the antitoxin gene is usually ...
He Zhang, Shuan Tao, Huimin Chen, Yewei Fang, Yao Xu, A-Xiang Han, Fang Ma, Wei Liang   +7 more
openaire   +4 more sources

Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of <i>Legionella pneumophila</i>. [PDF]

mBio, 2023
Lin JD, Stogios PJ, Abe KT, Wang A, MacPherson J, Skarina T, Gingras A-C, Savchenko A, Ensminger AW.   +8 more
europepmc   +1 more source