Results 81 to 90 of about 17,352,598 (197)

Characterisation of VapBC Toxin-Antitoxins from Mycobacterium tuberculosis [PDF]

, 2013
Toxin-antitoxin (TA) systems were identified more than 20 years ago on the mini F plasmid of Escherichia coli as plasmid stability elements; components responsible for purging bacterial cells that lack the plasmid from the population.
Sharrock, Abigail Victoria
core  

Control of Toxin-Antitoxin Systems by Proteases in Mycobacterium Tuberculosis

Frontiers in Molecular Biosciences, 2021
Toxin-antitoxin (TA) systems are small genetic elements composed of a noxious toxin and a counteracting cognate antitoxin. Although they are widespread in bacterial chromosomes and in mobile genetic elements, their cellular functions and activation ...
Patricia Bordes, Pierre Genevaux
doaj   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis

Infection and Immunity
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner, Samantha D’Spain, Rachel Ende, Isabelle Derré   +3 more
doaj   +1 more source

Metabolomics‐based study of the preservation mechanism of a tea saponin–cinnamaldehyde nanoemulsion applied to Xinyu tangerines

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background The Xinyu tangerine is a geographical indication agricultural product from Jiangxi province, China. During postharvest storage, nutrient loss and pathogen‐induced decay reduce fruit quality. The selection of appropriate preservatives is therefore important for maintaining postharvest quality.
Yan Leng, Xinjian Gao, Yichen Zhang, Zehang Yan, Wanyi Chen, Yang Huang, Xiaoxia Zuo, Liqin Zhu, Zhipeng Cai, Jing Wang, Yonggen Shen   +10 more
wiley   +1 more source

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS

, 2012
International audienceAmong bacterial toxin-antitoxin systems, to date no antitoxin has been identified that functions by cleaving toxin mRNA. Here we show that YjdO (renamed GhoT) is a membrane lytic peptide that causes ghost cell formation (lysed cells
Wolfgang Peti, Zheng, Kevin, Rebecca Page, Hsin-Yao Cheng, Torsten Herrmann, Xiaoxue Wang, Devon O Osbourne, Michael J Benedik, Cecilia Quiroga, Viviana Sanchez-Torres, Seok Hoon Hong, Kevin Zheng, Wang, Xiaoxue, Sanchez-Torres, Viviana, Thomas K Wood, Lord, Dana M, Benedik, Michael J, Cheng, Hsin-Yao, Quiroga, Cecilia, Wood, Thomas K, Peti, Wolfgang, Herrmann, Torsten, Dana M Lord, Page, Rebecca, Hong, Seok Hoon, Osbourne, Devon O   +25 more
core   +1 more source

Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics

mLife, EarlyView.
Abstract Persistent bacteria subpopulations showing multidrug tolerance pose significant challenges to antibiotic therapy. While the HipBA toxin–antitoxin (TA) system is known to play a role in persister formation, existing studies predominantly focus on its kinase activity and intracellular regulatory pathways, with limited attention to the ...
Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang   +4 more
wiley   +1 more source

Time to Diagnosis and Persistence: The Two Major Determinants of Effective Tuberculosis Control [PDF]

, 2015
The greatest challenge confronting effective tuberculosis (TB) eradication is the time to diagnosis, and duration of treatment of chronically infected individuals which represent a pool of infection.
Ruthe, Alaine Tess
core  

ORF43/ORF44: a possible Toxin-Antitoxin system in phiCh1

, 2016
Eine Sequenzanalyse des Genoms von phiCh1 zeigte eine Pin Domäne im ORF44 auf, ein Hinweis auf ein Typ II Toxin/Antitoxin System. In dieser Bachelorarbeit wurden die Auswirkungen von ORF43/44, einem möglichem Toxin/Antitoxin System im Virus phiCh1 ...
Lebhard, Jürgen
core   +3 more sources

Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. [PDF]

PLoS ONE, 2010
RelBE represents a typical bacterial toxin-antitoxin (TA) system. Mycobacterium tuberculosis H37Rv, the pathogen responsible for human tuberculosis, contains three RelBE-like modules, RelBE, RelFG, and RelJK, which are at least partly expressed in human ...
Min Yang, Chunhui Gao, Yi Wang, Hua Zhang, Zheng-Guo He   +4 more
doaj   +1 more source