Results 81 to 90 of about 13,696 (172)
A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. [PDF]
PLoS ONE, 2009 Toxin-antitoxin (TA) modules are gene pairs specifying for a toxin and its antitoxin and are found on the chromosomes of many bacteria including pathogens. Here we report how each of five such TA systems in E. coli affect bacterial cell death differently
Ilana Kolodkin-Gal +3 more
doaj +1 more source
Protein design and RNA design: Perspectives
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley +1 more source
Adverse Drug Reaction Study of Botulinum Toxin‐A in the Real World
Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.ABSTRACT Background Despite the increasing use of botulinum toxin type A (BoNT‐A) in aesthetic and therapeutic applications, its real‐world adverse drug reaction (ADR) profile remains incompletely characterized. Current evidence relies largely on small‐scale clinical observations rather than large, systematic analyses.
Jiaxu Gu +9 more
wiley +1 more source
Toxin-Antitoxin Systems in the Mobile Genome of Acidithiobacillus ferrooxidans
PLoS ONE, 2014 Toxin-antitoxin (TA) systems are genetic modules composed of a pair of genes encoding a stable toxin and an unstable antitoxin that inhibits toxin activity. They are widespread among plasmids and chromosomes of bacteria and archaea. TA systems are known to be involved in the stabilization of plasmids but there is no consensus about the function of ...
Bustamante, Paula +2 more
openaire +7 more sources
Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems
Frontiers in Molecular Biosciences, 2016 In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan +2 more
doaj +1 more source
Turmeric and curcumin: From traditional medicine to modern therapeutic applications
JSFA reports, Volume 6, Issue 5, Page 160-178, May 2026.Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem +7 more
wiley +1 more source
Protein Science, Volume 35, Issue 5, May 2026.Abstract Pseudomonas aeruginosa is a prominent opportunistic pathogen whose virulence is closely linked to its Type III Secretion System (T3SS), a specialized apparatus that injects effector proteins into host cells. T3SS chaperones are essential for stabilizing, delivering, and regulating T3SS expression.
Jing Zhang
wiley +1 more source
Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation
npj Systems Biology and ApplicationsAntibiotic persistence, characterized by a dormant subpopulation of bacterial cells that causes chronic and recurrent infections, remains poorly understood despite being recognized nearly a century ago. Toxin–antitoxin (TA) systems, which include a toxin
Sofija Markovic +3 more
doaj +1 more source
Evolution of the SpoIISABC Toxin-Antitoxin-Antitoxin System in Bacilli
Toxins, 2016 Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIISABC system, originally identified in Bacillus subtilis, consists of three components: a SpoIISA toxin and the SpoIISB and SpoIISC antitoxins ...
Marek Gabriško, Imrich Barák
doaj +1 more source
The Prevalence and Diversity of Marine Toxin–Antitoxin Systems
Marine DrugsToxin-antitoxin (TA) systems, ubiquitous in bacterial and archaeal genomes, play pivotal roles in responding to environmental stresses, forming biofilms, defending against phages, and influencing pathogen virulence. The marine environment harbors Earth’s most diverse and abundant microbial communities, where microorganisms have evolved unique genetic ...
Cong Liu +5 more
openaire +3 more sources