Results 151 to 160 of about 13,696 (172)

Toxin-antitoxin systems in mycobacterial infections

2021
With an increase in antibiotic therapy failure, there has been a surge of research to understand antibiotic persistence. The distinct subpopulation of cells that can survive antibiotic treatment are called “persisters”. The persister cells also account for group of cells that cause “persistent infection” by evading human immune system, for example ...
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Chromosomal bacterial type II toxin–antitoxin systems

Canadian Journal of Microbiology, 2012
Most prokaryotic chromosomes contain a number of toxin–antitoxin (TA) modules consisting of a pair of genes that encode 2 components, a stable toxin and its cognate labile antitoxin. TA systems are also known as addiction modules, since the cells become “addicted” to the short-lived antitoxin product (the unstable antitoxin is degraded faster than the
Mohammad Adnan, Syed, Céline M, Lévesque   +1 more
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Toxin-Antitoxin Systems

2021
M. Mahmoudi, S. Ghafourian, A. Maleki
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Toxin–antitoxin systems: why so many, what for?

Current Opinion in Microbiology, 2010
Toxin-antitoxin (TA) systems are small genetic modules that are abundant in bacterial genomes. Three types have been described so far, depending on the nature and mode of action of the antitoxin component. While type II systems are surprisingly highly represented because of their capacity to move by horizontal gene transfer, type I systems appear to ...
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[Functions of bacterial Toxin-Antitoxin systems].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019
TA (Toxin-Antitoxin) systems are widely spread in chromosomes and plasmids of bacteria and archaea. These systems consist of two co-expression genes, encoding stable toxin and sensitive antitoxin, respectively. The toxicity of toxins usually inhibits bacterial growth and antitoxins can neutralize the toxins.
Zhili, He, Hui, Wang
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Prokaryotic toxin–antitoxin systems: novel regulations of the toxins

Current Genetics, 2016
Toxin-antitoxin (TA) systems are widely conserved in prokaryotic plasmids and chromosomes and are linked to many roles in cell physiology, including plasmid maintenance, stress response, persistence and protection from phage infection. A TA system is composed of a stable toxin and a labile antitoxin that inhibits a harmful effect of the cognate toxin ...
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Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection

Molecular Cell, 2021
Chantal K Guegler, Michael T Laub
exaly  

Functional characterization of toxin-antitoxin system in Mycobacterium tuberculosis

Indian Journal of Tuberculosis, 2023
Karthikeyan Sundaram
exaly  

Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number

Proceedings of the National Academy of Sciences of the United States of America, 2021
Songwei Ni, Baiyuan Li, Kaihao Tang
exaly  

The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA

Molecular Cell, 2016
Gytis Jankevicius, Antonio Ariza, Marijan Ahel   +2 more
exaly