Results 191 to 200 of about 23,162 (212)

Toxin-Antitoxin Systems in Bacteria and Archaea

Annual Review of Genetics, 2011
Almost all bacteria and many archaea contain genes whose expression inhibits cell growth and may lead to cell death when overproduced, reminiscent of apoptotic genes in higher systems. The cellular targets of these toxins are quite diverse and include DNA replication, mRNA stability, protein synthesis, cell-wall biosynthesis, and ATP synthesis.
Yoshihiro, Yamaguchi, Jung-Ho, Park, Masayori, Inouye   +2 more
openaire   +2 more sources

Toxin–antitoxin systems: Classification, biological roles, and applications

Microbiological Research, 2022
Toxin-antitoxin (TA) systems, composed of a stable toxin and a cognate unstable antitoxin, are ubiquitous in the genomes of bacteria and archaea. Under suitable growth conditions, an antitoxin prevents its cognate toxin from inducing toxicity; nonetheless, under stress or plasmid loss, it is either rapidly degraded or downregulated, thereby freeing the
Jun, Qiu, Yimeng, Zhai, Man, Wei, Chengkun, Zheng, Xinan, Jiao   +4 more
openaire   +2 more sources

Toxin-Antitoxin Systems

2021
M. Mahmoudi, S. Ghafourian, A. Maleki
openaire   +1 more source

[Functions of bacterial Toxin-Antitoxin systems].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019
TA (Toxin-Antitoxin) systems are widely spread in chromosomes and plasmids of bacteria and archaea. These systems consist of two co-expression genes, encoding stable toxin and sensitive antitoxin, respectively. The toxicity of toxins usually inhibits bacterial growth and antitoxins can neutralize the toxins.
Zhili, He, Hui, Wang
openaire   +1 more source

Toxin–antitoxin systems: why so many, what for?

Current Opinion in Microbiology, 2010
Toxin-antitoxin (TA) systems are small genetic modules that are abundant in bacterial genomes. Three types have been described so far, depending on the nature and mode of action of the antitoxin component. While type II systems are surprisingly highly represented because of their capacity to move by horizontal gene transfer, type I systems appear to ...
openaire   +2 more sources

Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems

Nature, 2022
Jacob Bobonis, Karin Mitosch, André Mateus   +2 more
exaly  

Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection

Molecular Cell, 2021
Chantal Guegler, Laub Mt
exaly  

Toxin–antitoxin to the rescue against phages

Nature Reviews Microbiology, 2022
exaly  

Regulation of growth and death in Escherichia coli by toxin–antitoxin systems

Nature Reviews Microbiology, 2011
Yoshihiro Yamaguchi, Masayori Inouye
exaly  

Prokaryotic toxin–antitoxin stress response loci

Nature Reviews Microbiology, 2005
Kenn Gerdes, Anders Løbner-Olesen
exaly