Results 41 to 50 of about 24,156 (244)
Prevalence of Fst-like toxin–antitoxin systems [PDF]
Microbiology, 2010 Toxin–antitoxin (TA) systems are widespread in Gram-negative bacteria, and all systems identified to date encode a toxic protein and an unstable antitoxin, which may be in the form of either an antisense RNA (type I) or a second protein (type II). The enterococcal plasmid pAD1-encoded TA system (par), encoding the Fst toxin, was the first type I TA ...
Kwong, Stephen M. (R20881) +2 more
openaire +3 more sources
YoeB toxin is activated during thermal stress. [PDF]
, 2015 Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando +2 more
core +1 more source
Frontiers in Microbiology, 2021 The extraordinary expansion of Toxin Antitoxin (TA) modules in the genome of Mycobacterium tuberculosis has received significant attention over the last few decades.
Arun Sharma +10 more
doaj +1 more source
Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis [PDF]
Toxins, 2014 The hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease. To date, the cellular factors and the molecular mechanisms that mediate entry into the persistence phase are poorly understood. Remarkably, M.
Ambre Sala +2 more
openaire +3 more sources
Phage ϕC2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains [PDF]
, 2013 UNLABELLED: In this work, we show that Clostridium difficile phage ϕC2 transduces erm(B), which confers erythromycin resistance, from a donor to a recipient strain at a frequency of 10(-6) per PFU.
Chang, Barbara J +5 more
core +3 more sources
Dynamics-Based Regulatory Switches of Type II Antitoxins: Insights into New Antimicrobial Discovery
Antibiotics, 2023 Type II toxin-antitoxin (TA) modules are prevalent in prokaryotes and are involved in cell maintenance and survival under harsh environmental conditions, including nutrient deficiency, antibiotic treatment, and human immune responses. Typically, the type
Ki-Young Lee, Bong-Jin Lee
doaj +1 more source
Hypothetical Functions of Toxin-Antitoxin Systems [PDF]
Journal of Bacteriology, 2007 Toxin-antitoxin systems are very commonly found both on large, low-copy plasmids, where they increase effective stability ([35][1]), and on bacterial chromosomes, where their function has been the subject of considerable speculation.
openaire +2 more sources
Small Open Reading Frames, Non-Coding RNAs and Repetitive Elements in Bradyrhizobium japonicum USDA 110 [PDF]
, 2016 Small open reading frames (sORFs) and genes for non-coding RNAs are poorly investigated components of most genomes. Our analysis of 1391 ORFs recently annotated in the soybean symbiont Bradyrhizobium japonicum USDA 110 revealed that 78% of them contain ...
Cuklina, Jelena +5 more
core +2 more sources
Charged Amino Acids Contribute to ZorO Toxicity
Toxins, 2022 Chromosomally encoded toxin-antitoxin systems have been increasingly identified and characterized across bacterial species over the past two decades. Overproduction of the toxin gene results in cell growth stasis or death for the producing cell, but co ...
Bikash Bogati +4 more
doaj +1 more source
The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii [PDF]
, 2014 Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates.
Ghafourian, S +6 more
core +5 more sources