Results 101 to 110 of about 2,065,037 (263)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The isolation and characterisation of temperature-dependent Ricin A chain molecules in Saccharomyces cerevisiae. [PDF]

, 2007
Ricin is a heterodimeric plant protein that is potently toxic to mammalian cells. Toxicity results from the catalytic depurination of eukaryotic ribosomes by ricin A chain (RTA) that follows toxin endocytosis to, and translocation across, the ...
Ladds, Graham, Moffat, K G, Allen, Stuart C H, Fulop, V, Moore, Katherine A. H., Marsden, Catherine J., Marsden, C J, Ladds, G, Roberts, L M, Lord, Mike, Lord, J M, Allen, Stuart C. H., Roberts, L. M. (Lynne M.), Moffat, Kevin G., Fülöp, Vilmos, Moore, K A H   +15 more
core   +1 more source

Investigation of a foodborne disease outbreak caused by Clostridium perfringens in Guizhou Province and pathogen tracing

Zhongguo shipin weisheng zazhi
ObjectiveEpidemiological investigation of a foodborne disease outbreak triggered by Clostridium perfringens in a school in Guiyang， traceability analysis of etiologic foods and pathogens， and exploration of the application of the new technology of whole ...
ZHANG Li, DAI Hua, JIAN Jie, HUANG Jingyu, JIANG Jiajun, ZHOU Yajuan, TIAN Jigui, ZHU Shu, LIAO Chun, LI Jun, LI Weiwei, GUO Hua   +11 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Real-time multiplex PCR assays for reliable detection of Clostridium perfringens toxin genes in animal isolates

, 2008
Typing of Clostridium perfringens strains by PCR-based determination of toxin genes proved to be a reliable method for diagnosis of enterotoxaemia in various animal species.
Miserez, R, Brodard, I, Frey, J, Jaussi, A, Wollschlaeger, N, Abril, C, Albini, S   +6 more
core   +1 more source

Distribution of RTX toxin genes in strains of [Actinobacillus] rossii and [Pasteurella] mairii [PDF]

, 2006
Strains of [Actinobacillus] rossii, [Pasteurella] mairii and [Pasteurella] aerogenes can be isolated from abortion in swine. The RTX toxin Pax has previously been found only in those [P.] aerogenes strains isolated from abortion.
Frey, Joachim, Mayor, Désirée, Bisgaard, Magne, Korczak, Bozena M., Kuhnert, Peter, Korczak, Bozena M, Christensen, Henrik   +6 more
core   +1 more source

Reduced Virulence Caused by Meiotic Instability of the TOX2 Chromosome of the Maize Pathogen Cochliobolus carbonum

Molecular Plant-Microbe Interactions, 2000
The mechanisms by which pathogenic fungi evolve are poorly understood. Production of the host-selective cyclic peptide HC-toxin is controlled by a complex locus, TOX2, in the plant pathogen Cochliobolus carbonum.
John W. Pitkin, Anastasia Nikolskaya, Joong-Hoon Ahn, Jonathan D. Walton   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Detection of RTX toxin genes in gram-negative bacteria with a set of specific probes [PDF]

, 1997
The family of RTX (RTX representing repeats in the structural toxin) toxins is composed of several protein toxins with a characteristic nonapeptide glycine-rich repeat motif. Most of its members were shown to have cytolytic activity.
Burnens, André, Frey, Joachim, Heyberger-Meyer, B, Kuhnert, Peter, Nicolet, Jacques   +4 more
core