Results 91 to 100 of about 2,065,037 (263)

Whole Transcriptomic Analysis Provides Insights into Molecular Mechanisms for Toxin Biosynthesis in a Toxic Dinoflagellate Alexandrium catenella (ACHK-T)

Toxins, 2017
Paralytic shellfish toxins (PSTs), a group of neurotoxic alkaloids, are the most potent biotoxins for aquatic ecosystems and human health. Marine dinoflagellates and freshwater cyanobacteria are two producers of PSTs.
Yong Zhang, Shu-Fei Zhang, Lin Lin, Da-Zhi Wang   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Regulated transcription of Clostridium difficile toxin genes

, 1998
International audienceThe Clostridium difficile toxA and toxB genes, encoding cytotoxic and enterotoxic proteins responsible for antibiotic‐associated colitis and pseudomembranous colitis, were shown to be transcribed both from gene‐specific promoters ...
Sonenshein, Abraham, Dupuy, Bruno
core   +1 more source

Botulinum toxin-A for the treatment of overactive bladder: UK contributions [PDF]

, 2013
Background: Botulinum toxin-A (BoNT/A) is now established second-line management for refractory overactivebladder (OAB) and recognised in many incontinence guidelines and pathways.
Fowler, CJ, Panicker, J. N., Fowler, C. J., Dowson, C, Khan, MS, Seth, JH, Dasgupta, P, Dasgupta, P., Panicker, JN, Sahai, A, Dowson, C., Seth, J. H., Khan, M. S., Sahai, Arun   +13 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The prevalence of C. difficile infection by culture method and typing toxin genes by multiplex polymerase chain reaction (mPCR)

Journal of Associated Medical Sciences, 2014
Introduction: Clostridium difficile-associated diarrhea is a global health problem. The pathogenicity of this bacterium is determined by production of two major toxins: enterotoxin A and cytotoxin B.
Piyada Wangroongsarb, Thanitchai Kamthalang, Chutima Jittaprasatsin, Karun Suthivarakom, Nattapong Cheunban, Somchai Sangkitporn   +5 more
doaj  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids.

PLoS ONE, 2007
BackgroundClostridium botulinum and related clostridial species express extremely potent neurotoxins known as botulinum neurotoxins (BoNTs) that cause long-lasting, potentially fatal intoxications in humans and other mammals.
Theresa J Smith, Karen K Hill, Brian T Foley, John C Detter, A Christine Munk, David C Bruce, Norman A Doggett, Leonard A Smith, James D Marks, Gary Xie, Thomas S Brettin   +10 more
doaj   +1 more source

A Decarboxylase Encoded at the Cochliobolus heterostrophus Translocation-Associated Tox1B Locus Is Required for Polyketide (T-toxin) Biosynthesis and High Virulence on T-cytoplasm Maize

Molecular Plant-Microbe Interactions, 2002
Genes at two unlinked loci (Tox1A and Tox1B) are required for production of the polyketide T-toxin by Cochliobolus heterostrophus race T, a pathogenic fungus that requires T-toxin for high virulence to maize with T-cytoplasm. Previous work indicated that
Mark S. Rose, Sung-Hwan Yun, Thipa Asvarak, Shun-Wen Lu, O. C. Yoder, B. Gillian Turgeon   +5 more
doaj   +1 more source