Results 111 to 120 of about 2,065,037 (263)

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin [PDF]

, 2016
FIC domain proteins mediate post-translational modifications of target proteins, which typically results in their inactivation. Depending on the conservation of crucial active site residues, the FIC fold serves as structural scaffold for various ...
Stanger, Frédéric V., Frédéric V Stanger, Tilman Schirmer, Alexander Harms (3132942), Dehio, Christoph, Harms, Alexander, Schirmer, Tilman, Christoph Dehio, Frédéric V. Stanger (585551), Alexander Harms, Tilman Schirmer (585552), Christoph Dehio (200951)   +11 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Constitutive Activation of the Midgut Response to Bacillus thuringiensis in Bt-Resistant Spodoptera exigua [PDF]

, 2010
Bacillus thuringiensis is the most effective microbial control agent for controlling numerous species from different insect orders. The main threat for the long term use of B. thuringiensis in pest control is the ability of insects to develop resistance.
Ferre, J., Ferré, Juan, CACCIA, SILVIA, Navarro Cerrillo, Gloria, Juan Ferré, Escriche, Baltasar, Navarro-Cerrillo, G., Escriche, B., William J Moar, Silvia Caccia, Herrero, S., de Maagd, Ruud A, de Maagd Ruud A., de Maagd, R.A., Moar William J., Ruud A. de Maagd, Salvador Herrero, S. Herrero, Moar, W.J., W. J. Moar, Hernandez-Martinez, P., Ruud A de Maagd, Moar, William J, Escriche Baltasar, P. Hernández Martínez, Patricia Hernández-Martínez, Navarro-Cerrillo Gloria, Herrero Salvador, Hernández Martínez, Patricia, Gloria Navarro-Cerrillo, Baltasar Escriche, J. Ferré, Hernández-Martínez Patricia, Maagd, R.A., de, William J. Moar, Ferré Juan, Herrero, Salvador, B. Escriche, G. Navarro Cerrillo, R. A. de Maagd, Caccia, S., Caccia Silvia, S. Caccia   +42 more
core   +2 more sources

A Multi-Layer-Controlled Strategy for Cloning and Expression of Toxin Genes in Escherichia coli. [PDF]

Toxins (Basel), 2023
Vandierendonck J, Girardin Y, De Bruyn P, De Greve H, Loris R.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Shiga Toxin: Expression, Distribution, and Its Role in the Environment

Toxins, 2011
In this review, we highlight recent work that has increased our understanding of the production and distribution of Shiga toxin in the environment. Specifically, we review studies that offer an expanded view of environmental reservoirs for Shiga toxin ...
Steven A. Mauro, Gerald B. Koudelka
doaj   +1 more source

Evolution of Three-Finger Toxin Genes in Neotropical Colubrine Snakes (Colubridae). [PDF]

Toxins (Basel), 2023
Srodawa K, Cerda PA, Davis Rabosky AR, Crowe-Riddell JM.   +3 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Nemertean toxin genes revealed through transcriptome sequencing [PDF]

, 2014
Nemerteans are one of few animal groups that have evolved the ability to utilize toxins for both defense and subduing prey, but little is known about specific nemertean toxins.
Halanych, Kenneth M, Whelan, Nathan V, Kevin M. Kocot, Kocot, Kevin M, Santos, Scott R, Scott R. Santos, Kenneth M. Halanych, Nathan V. Whelan, Whelan, Nathan V., Kocot, Kevin M., Santos, Scott R., Halanych, Kenneth M.   +11 more
core   +1 more source

Profiling toxin genes and antibiotic resistance in Bacillus cereus isolated from pre-launch spacecraft. [PDF]

Front Microbiol, 2023
Mohammadi B, Gorkina N, Pérez-Reyes ME, Smith SA.   +3 more
europepmc   +1 more source