Results 61 to 70 of about 286,913 (269)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Synergism between fungal enzymes and bacterial antibiotics may enhance biocontrol [PDF]

, 2002
The interactions between biocontrol fungi and bacteria may play a key role in the natural process of biocontrol, although the molecular mechanisms involved are still largely unknown.
FOGLIANO, VINCENZO, LORITO, MATTEO, SCALA, FELICE, WOO, SHERIDAN LOIS   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Friends or Foes? Emerging Impacts of Biological Toxins [PDF]

Trends in Biochemical Sciences, 2019
Toxins are substances produced from biological sources (e.g., animal, plants, microorganisms) that have deleterious effects on a living organism. Despite the obvious health concerns of being exposed to toxins, they are having substantial positive impacts in a number of industrial sectors.
Clark, Graeme C., Casewell, Nicholas R., Elliott, Christopher T., Harvey, Alan L., Jamieson, Andrew G., Strong, Peter N., Turner, Andrew D.   +6 more
openaire   +5 more sources

Review of mycotoxin reduction in food and feed: from prevention in the field to detoxification by adsorption or transformation [PDF]

, 2011
Mycotoxins are secondary metabolites present worldwide in agricultural commodities and produced by filamentous fungi that cause a toxic response (mycotoxicosis) when ingested by animals.
Guyonvarc’h, Alain, Jard, Gwénaëlle, Lebrihi, Ahmed, Liboz, Thierry, Mathieu, Florence   +4 more
core   +4 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model [PDF]

, 2004
The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model.
Chow C C, Clay J R, DeFelice L J, Fox R F, G Schmid, Gammaitoni L, Goldman M S, Hille B, Hodgkin A L, Hänggi P, Hänggi P, I Goychuk, Lecar H, LeMasson G, P Hänggi, Press W H, Skaugen E, Strassberg A F   +17 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Characterization of Ricin and R. communis Agglutinin Reference Materials

Toxins, 2015
Ricinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted interest as a potential ...
Sylvia Worbs, Martin Skiba, Martin Söderström, Marja-Leena Rapinoja, Reinhard Zeleny, Heiko Russmann, Heinz Schimmel, Paula Vanninen, Sten-Åke Fredriksson, Brigitte G. Dorner   +9 more
doaj   +1 more source