Results 71 to 80 of about 2,559,591 (306)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Marine Algal Toxins and Public Health: Insights from Shellfish and Fish, the Main Biological Vectors

Exposure to toxigenic harmful algal blooms (HABs) can result in widely recognized acute poisoning in humans. The five most commonly recognized HAB-related illnesses are diarrhetic shellfish poisoning (DSP), paralytic shellfish poisoning (PSP), amnesic ...
Hong-Ye Li, Kuan-Kuan Yuan, Wei-Dong Yang   +2 more
core   +1 more source

Membrane‐Damaging Toxins: Family of RTX Toxins

, 2003
The major cellular effect of RTX toxins has been ascribed to their pore‐forming capacity, resulting in plasma membrane lesions and osmotic lysis.
Oxhamre, C, Richter‐Dahlfors, A
core   +1 more source

Characterization of Ricin and R. communis Agglutinin Reference Materials

Toxins, 2015
Ricinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted interest as a potential ...
Sylvia Worbs, Martin Skiba, Martin Söderström, Marja-Leena Rapinoja, Reinhard Zeleny, Heiko Russmann, Heinz Schimmel, Paula Vanninen, Sten-Åke Fredriksson, Brigitte G. Dorner   +9 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

CDC's laboratory response to toxins [PDF]

Toxins are some of the most deadly chemicals known and represent an ongoing bioterrorism threat.1 The Centers for Disease Control and Prevention (CDC) has developed specific and sensitive methods to help diagnose, treat, and prevent diseases caused by ...

core  

The Biological Properties of Bacterial Toxins

Вестник войск РХБ защиты
Knowledge of the biological properties of bacterial toxins is constantly being updated. Over the past two decades, the research interest has shifted from natural toxins to their genetically modified derivatives.
M. V. Supotnitskiy
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Molecular mechanisms underlying early functional divergence in snake venom inferred from the genomes of two pitviper lineages

BMC Biology
Background The molecular mechanisms that underlie adaptive divergence in complex traits can be assessed in traits like animal venoms where variation in gene sequence and expression levels can be directly linked to functional divergence in phenotypes.
Andrew J. Mason, Pedro G. Nachtigall, Darin R. Rokyta, Christopher L. Parkinson, Felipe G. Grazziotin, Inácio L. M. Junqueira-de-Azevedo, H. Lisle Gibbs   +6 more
doaj   +1 more source