Results 71 to 80 of about 129,432 (263)
Biological Toxins in Foods: Source and Preservation [PDF]
Egyptian Journal of Animal HealthBiological toxins are hazardous Compounds produced by a wide range of living organisms, including microorganisms, plants, and animals, and they pose a significant threat to the health of humans, animals, and even other plants. By definition, a toxin is a
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Biological effects of uremic toxins
Romanian Journal of Infectious Diseases, 2015 Progressive accumulation of uremic toxins in the body exerts a variety of adverse effects on all organs, tissues and systems. The elimination of these compounds from the body is a major goal in the international scientific community. The objectives of this study are: uremic toxins classification, presentation of nocive effects of uremic toxins in human
Corina Daniela Ene +3 more
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Phytopathology ResearchBrown blotch disease in Agaricus bisporus reduces its commercial value, resulting in significant economic losses. The pathogens of brown blotch disease are diverse.
Zaixing Huang +3 more
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FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety?
Toxins, 2012 Shiga toxins and ricin are well characterized similar toxins belonging to quite different biological kingdoms. Plant and bacteria have evolved the ability to produce these powerful toxins in parallel, while humans have evolved a defense system that ...
Maurizio Brigotti
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