Results 81 to 90 of about 2,559,591 (306)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Microorganisms and their byproducts, nematodes, oils and particle films have important agricultural uses

California Agriculture, 2005
The insect and mite control potential of natural and biological toxins has been recognized for several centuries. Bacteria, viruses, protozoa and fungi are the primary groups of microorganisms known to reduce insect populations; they often occur ...
L Godfrey, E Grafton-Cardwell, H Kaya, W Chaney   +3 more
doaj   +2 more sources

Identifying biological pathway interrupting toxins using multi-tree ensembles

Frontiers in Environmental Science, 2016
The pharmaceutical industry constantly seeks new ways to improve current methods that scientists use to evaluate environmental chemicals and develop new medicines.
Gergo Barta
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Marine Toxins Detection by Biosensors Based on Aptamers

, 2019
Marine toxins cause great harm to human health through seafood, therefore, it is urgent to exploit new marine toxins detection methods with the merits of high sensitivity and specificity, low detection limit, convenience, and high efficiency. Aptasensors
Zhaoming Liu, Wei Ye, Muzi Zhu, Taomei Liu, Weimin Zhang, Shan Liu, Yali Kong   +6 more
core   +1 more source

Distribution of major toxins in Rhinella marina parotoid macroglands using Desorption-Electrospray-Ionization mass spectrometry imaging (DESI-MSI)

Toxicon: X, 2020
Amphibian cutaneous glands secrete toxins used in different vital functions including passive defense. Through Desorption Electrospray Ionization-Imaging we analyzed the distribution of the major toxins of the toad Rhinella marina parotoid macroglands ...
Pedro L. Mailho-Fontana, Andreia M. Porcari, Marcos N. Eberlin, Carlos Jared, Marta Maria Antoniazzi, Daniel C. Pimenta, Juliana M. Sciani   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Research Status of Embryonic Developmental Toxicity and Biological Monitoring of Exposure to Traditional and Emerging Mycotoxins during Pregnancy

Liang you shipin ke-ji
Mycotoxins are toxic secondary metabolites produced by certain fungal species under specific conditions. Research has found that exposure to various fungal toxins can cause embryonic developmental toxicity, such as embryo arrest, abortion, and ...
HAN Xiao-min, YE Jin, JI Jian, XU Wen-jing, WU Yu, YE Yong-li, Rudolf KRSKA, SUN Xiu-lan, BAI Li   +8 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Review of the Inhibition of Biological Activities of Food-Related Selected Toxins by Natural Compounds

, 2013
There is a need to develop food-compatible conditions to alter the structures of fungal, bacterial, and plant toxins, thus transforming toxins to nontoxic molecules. The term ‘chemical genetics’ has been used to describe this approach.
Mendel Friedman, Reuven Rasooly
core   +1 more source