Results 81 to 90 of about 3,525,662 (309)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Microorganisms and their byproducts, nematodes, oils and particle films have important agricultural uses

California Agriculture, 2005
The insect and mite control potential of natural and biological toxins has been recognized for several centuries. Bacteria, viruses, protozoa and fungi are the primary groups of microorganisms known to reduce insect populations; they often occur ...
L Godfrey, E Grafton-Cardwell, H Kaya, W Chaney   +3 more
doaj   +2 more sources

Molecular mechanisms underlying early functional divergence in snake venom inferred from the genomes of two pitviper lineages

BMC Biology
Background The molecular mechanisms that underlie adaptive divergence in complex traits can be assessed in traits like animal venoms where variation in gene sequence and expression levels can be directly linked to functional divergence in phenotypes.
Andrew J. Mason, Pedro G. Nachtigall, Darin R. Rokyta, Christopher L. Parkinson, Felipe G. Grazziotin, Inácio L. M. Junqueira-de-Azevedo, H. Lisle Gibbs   +6 more
doaj   +1 more source

Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics

Toxins, 2019
Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make
Daniele Chaves-Moreira, Fernando Hitomi Matsubara, Zelinda Schemczssen-Graeff, Elidiana De Bona, Vanessa Ribeiro Heidemann, Clara Guerra-Duarte, Luiza Helena Gremski, Carlos Chávez-Olórtegui, Andrea Senff-Ribeiro, Olga Meiri Chaim, Raghuvir Krishnaswamy Arni, Silvio Sanches Veiga   +11 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Identifying biological pathway interrupting toxins using multi-tree ensembles

Frontiers in Environmental Science, 2016
The pharmaceutical industry constantly seeks new ways to improve current methods that scientists use to evaluate environmental chemicals and develop new medicines.
Gergo Barta
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Distribution of major toxins in Rhinella marina parotoid macroglands using Desorption-Electrospray-Ionization mass spectrometry imaging (DESI-MSI)

Toxicon: X, 2020
Amphibian cutaneous glands secrete toxins used in different vital functions including passive defense. Through Desorption Electrospray Ionization-Imaging we analyzed the distribution of the major toxins of the toad Rhinella marina parotoid macroglands ...
Pedro L. Mailho-Fontana, Andreia M. Porcari, Marcos N. Eberlin, Carlos Jared, Marta Maria Antoniazzi, Daniel C. Pimenta, Juliana M. Sciani   +6 more
doaj   +1 more source

Biological effects of uremic toxins

Romanian Journal of Infectious Diseases, 2015
Progressive accumulation of uremic toxins in the body exerts a variety of adverse effects on all organs, tissues and systems. The elimination of these compounds from the body is a major goal in the international scientific community. The objectives of this study are: uremic toxins classification, presentation of nocive effects of uremic toxins in human
Corina Daniela Ene, Mircea Penescu, Emanoil Ceauşu, Ilinca Nicolae   +3 more
openaire   +1 more source