Results 61 to 70 of about 2,552,266 (246)

Acknowledgement to Reviewers of Toxins in 2014

, 2015
The editors of Toxins would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...
Toxins Editorial Office
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Colubrid Venom Composition: An -Omics Perspective

Toxins, 2016
Snake venoms have been subjected to increasingly sensitive analyses for well over 100 years, but most research has been restricted to front-fanged snakes, which actually represent a relatively small proportion of extant species of advanced snakes ...
Inácio L. M. Junqueira-de-Azevedo, Pollyanna F. Campos, Ana T. C. Ching, Stephen P. Mackessy   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dominant negative phenotype of Bacillus thuringiensis Cry1Ab, Cry11Aa and Cry4Ba mutants suggest hetero-oligomer formation among different Cry toxins. [PDF]

, 2011
Background - Bacillus thuringiensis Cry toxins are used worldwide in the control of different insect pests important in agriculture or in human health. The Cry proteins are pore-forming toxins that affect the midgut cell of target insects.
Leivi Portugal, Maagd, R.A., de, Daniela Carmona, Alejandra Bravo, Portugal, L., Bakker, P., Perez, C., Claudia Rodríguez-Almazán, Mario Soberón, Bravo, A., Rodriguez-Almazan, C., Carmona, D., Claudia Pérez, Soberon, M., Carlos Muñoz-Garay, Ruud A de Maagd, Munoz-Garay, C., Petra Bakker, Carmona Daniela, Portugal Leivi, Soberón Mario, de Maagd Ruud A., Ruud A. de Maagd, Pérez Claudia, Bakker Petra, Bravo Alejandra, Muñoz-Garay Carlos, Rodríguez-Almazán Claudia   +27 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Variability of Botulinum Toxins: Challenges and Opportunities for the Future

, 2018
Botulinum neurotoxins (BoNTs) are the most potent known toxins, and are therefore classified as extremely harmful biological weapons. However, BoNTs are therapeutic drugs that are widely used and have an increasing number of applications.
Rasetti-Escargueil, Christine, Michel R. Popoff, Popoff, Michel,, Popoff, Michel, R., Christine Rasetti-Escargueil, Emmanuel Lemichez, Lemichez, Emmanuel, Michel R. Popoff   +7 more
core   +1 more source

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord, Lord, Mike, Spooner, Robert A., Smith, Daniel C., Daniel C Smith, Roberts, L. M. (Lynne M.), Andrew J Easton, Easton, A. J. (Andrew J.), Robert A Spooner, Lynne M Roberts   +9 more
core   +1 more source