Results 41 to 50 of about 2,552,266 (246)

Recommended Immunological Strategies to Screen for Botulinum Neurotoxin-Containing Samples

Toxins, 2015
Botulinum neurotoxins (BoNTs) cause the life-threatening neurological illness botulism in humans and animals and are divided into seven serotypes (BoNT/A–G), of which serotypes A, B, E, and F cause the disease in humans. BoNTs are classified as “category
Stéphanie Simon, Uwe Fiebig, Yvonne Liu, Rob Tierney, Julie Dano, Sylvia Worbs, Tanja Endermann, Marie-Claire Nevers, Hervé Volland, Dorothea Sesardic, Martin B. Dorner   +10 more
doaj   +1 more source

AB Toxins: A Paradigm Switch from Deadly to Desirable

, 2010
To ensure their survival, a number of bacterial and plant species have evolved a common strategy to capture energy from other biological systems. Being imperfect pathogens, organisms synthesizing multi-subunit AB toxins are responsible for the mortality ...
Odumosu, Yano, Langridge, Nicholas
core   +2 more sources

Glycan Profile and Sequence Variants of Certified Ricin Reference Material and Other Ricin Samples Yield Unique Molecular Signature Features

Toxins
A certified reference material of ricin (CRM-LS-1) was produced by the EuroBioTox consortium to standardise the analysis of this biotoxin. This study established the N-glycan structures and proportions including their loci and occupancy of ricin CRM-LS-1.
Roland Josuran, Andreas Wenger, Christian Müller, Bettina Kampa, Sylvia Worbs, Brigitte G. Dorner, Sabina Gerber   +6 more
doaj   +1 more source

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test

Toxins, 2015
The detection and identification of botulinum neurotoxins (BoNT) is complex due to the existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert laboratories currently use different technical approaches to detect, identify and
Jasmin Weisemann, Nadja Krez, Uwe Fiebig, Sylvia Worbs, Martin Skiba, Tanja Endermann, Martin B. Dorner, Tomas Bergström, Amalia Muñoz, Ingrid Zegers, Christian Müller, Stephen P. Jenkinson, Marc-Andre Avondet, Laurence Delbrassinne, Sarah Denayer, Reinhard Zeleny, Heinz Schimmel, Crister Åstot, Brigitte G. Dorner, Andreas Rummel   +19 more
doaj   +1 more source

Review of the Inhibition of Biological Activities of Food-Related Selected Toxins by Natural Compounds

, 2013
There is a need to develop food-compatible conditions to alter the structures of fungal, bacterial, and plant toxins, thus transforming toxins to nontoxic molecules. The term ‘chemical genetics’ has been used to describe this approach.
Mendel Friedman, Reuven Rasooly
core   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19

Toxins, 2023
Animal-derived venoms are complex mixtures of toxins triggering important biological effects during envenomings. Although venom-derived toxins are known for their potential of causing harm to victims, toxins can also act as pharmacological agents. During
Isadora Oliveira, Isabela Ferreira, Beatriz Jacob, Kiara Cardenas, Felipe Cerni, Djane Baia-da-Silva, Eliane Arantes, Wuelton Monteiro, Manuela Pucca   +8 more
doaj   +1 more source

Acknowledgement to Reviewers of Toxins in 2013

, 2014
The editors of Toxins would like to express their sincere gratitude to the following reviewers for assessing manuscripts in ...
Toxins Editorial Office
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

N-Glycosylation Profile of Abrin Certified EU Reference Material

Toxins
Abrin is a highly toxic plant protein encompassing four isoforms, abrin-a, -b, -c and -d. An abrin reference material was isolated from Abrus precatorius and certified (EURM-113) by the EuroBioTox consortium.
Roland Josuran, Andreas Wenger, Sylvia Worbs, Bettina Kampa, Andreas Rummel, Brigitte G. Dorner, Sabina Gerber   +6 more
doaj   +1 more source