Results 1 to 10 of about 149,070 (296)
Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN [PDF]
RNA Biology, 2023 The TP53 and PTEN tumour suppressor genes are inactivated by nonsense mutations in a significant fraction of human tumours. TP53 nonsense mutant tumours account for approximately one million new cancer cases per year worldwide.
Angelos Heldin +9 more
doaj +2 more sources
Mutation Analysis and Single Nucleotide Polymorphism (SNP) of TP53 in Breast CancerIn East Java [PDF]
Journal of Tropical Life Science, 2021 The Incidence of Indonesia breast cancer case in2018 was reportedat 20.7% or160,653 in number. The factors that caused breast cancer is TP53gene mutationand Single Nucleotide Polymorphism (SNP).
Rizqa Radhiyah +4 more
doaj +1 more source
TP53 in Myelodysplastic Syndromes [PDF]
Cancers, 2021 Myelodysplastic syndromes (MDSs) are heterogeneous for their morphology, clinical characteristics, survival of patients, and evolution to acute myeloid leukemia. Different prognostic scoring systems including the International Prognostic Scoring System (IPSS), the Revised IPSS, the WHO Typed Prognostic Scoring System, and the Lower-Risk Prognostic ...
Yan Jiang +5 more
openaire +3 more sources
Biology Open, 2021 Human induced pluripotent stem cells (iPSCs) are important source for regenerative medicine. However, the links between pluripotency and oncogenic transformation raise safety issues.
Minglin Ou +11 more
doaj +1 more source
TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
Disease Models & Mechanisms, 2021 High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN).
Daniel Bronder +16 more
doaj +1 more source
Journal of Health Science and Medical Research (JHSMR), 2021 Objective: To determine the clinicopathologic features and germline tumor protein p53 (TP53) mutation in children with adrenocortical carcinoma (ACC). Material and Methods: This was a retrospective study.
Nadvadee Aungkawattanapong +9 more
doaj +1 more source
Age-related Variation in Expression of Breast Cancer Tumour Markers in Iranian Patients [PDF]
Middle East Journal of Cancer, 2021 Background: There are believed to be several risk factors affecting the prognosis of breast cancer through their effect on the growth rate of tumour.
Fatemeh Homaei Shandiz +6 more
doaj +1 more source
Catching the driver mutations in Ewing sarcoma tumours: an in silico genomic analysis [PDF]
World Cancer Research Journal, 2019 OBJECTIVE: Ewing sarcoma (EWS) is a rare neuroectodermal-related malignancy affecting bones and soft tissues. The well-known hallmark of genomic alteration in EWS is gene fusion involving the Ewing Sarcoma Breakpoint Region 1 (EWSR1) gene.
E. Toraih, A. Toreih, M. Fawzy
doaj +1 more source
Neural reprogramming via microRNAs: the new kid on the p53-deficient block
Molecular & Cellular Oncology, 2020 We recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. This directed sensory nerve reprogramming
Deborah A. Silverman +3 more
doaj +1 more source
A Computational Model of Tumor Growth and Anakoinosis
Frontiers in Pharmacology, 2019 Anakoinosis is a new cancer treatment paradigm that posits a key role for communicative reprogramming within tumor systems. To date no mathematical or computational models of anakoinosis have been developed.
Pan Pantziarka +3 more
doaj +1 more source