Results 11 to 20 of about 179,934 (163)

Quantitative Analysis of TP53-Related Lung Cancer Based on Radiomics

International Journal of General Medicine, 2022
Hongyu Qiao,1 Zhongxiang Ding,2 Youcai Zhu,1 Yuguo Wei,3 Baochen Xiao,1 Yongzhen Zhao,1 Qi Feng2 1Zhejiang Rongjun Hospital, Jiaxing, People’s Republic of China; 2Department of Radiology, Affiliated Hangzhou First People’s Hospital, Zhejiang University ...
Qiao H, Ding Z, Zhu Y, Wei Y, Xiao B, Zhao Y, Feng Q   +6 more
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Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy : results from the BIG 02-98 phase III trial [PDF]

, 2012
Introduction: Pre-clinical data suggest p53-dependent anthracycline-induced apoptosis and p53-independent taxane activity. However, dedicated clinical research has not defined a predictive role for TP53 gene mutations. The aim of the current study was to
Emmanuel Quinaux, Prudence A Francis, Lynnette Fernández-Cuesta, Dell'Orto, P, P. Falagan Lotsch, C. Oakman, A. D. Leo, Pierre Hainaut, Hainaut, P, Azambuja, Evandro De, P. A. Francis, Magali Olivier, D. Larsimont, Larsimont, D, E. Quinaux, G. Viale, Dolci, M Stella, M. S. Dolci, Martine Piccart-Gebhart, Francis, Prudence A, Oakman, C, Dell'orto, Patrizia, Viale, Giuseppe, Evandro De Azambuja, Priscila Falagan-Lotsch, Olivier, Magali, Crown, John, L. Fernández Cuesta, Ke-seay Smoth, Hainaut, Pierre, John Crown, Fernández-Cuesta, L, Viale, G, Leo, Angelo, Larsimont, Denis, M. Piccart Gebhart, Fernández-Cuesta, Lynnette, de Azambuja, Evandro, Giuseppe Viale, Falagan-Lotsch, P, Crown, J, Patrizia Dell'Orto, Piccart-Gebhart, Martine, M Stella Dolci, Piccart-Gebhart, M, Buyse, Marc, Quinaux, E, Denis Larsimont, M. Olivier, M. Buyse, Catherine Oakman, Quinaux, Emmanuel, P. Dell'orto, Olivier, M, Oakman, Catherine, Dolci, MS, Leo, Angelo Di, Buyse, M, Smoth, Ke-Seay, P. Hainaut, Smoth, KS, Azambuja, ED, Angelo Di Leo, J. Crown, Leo, AD, Dolci, Stella, E. D. Azambuja, Francis, P, Francis, PA, Falagan-Lotsch, Priscila, Marc Buyse, K. Smoth   +71 more
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Associations of Serum Tumor Biomarkers with Integrated Genomic and Clinical Characteristics of Hepatocellular Carcinoma

Liver Cancer, 2021
Introduction: Serum α-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-γ-carboxy­pro­thrombin (DCP) are useful biomarkers of hepatocellular carcinoma (HCC).
Keun Soo Ahn, Daniel R. O’Brien, Yong Hoon Kim, Tae-Seok Kim, Hiroyuki Yamada, Joong-Won Park, Sang-Jae Park, Seoung Hoon Kim, Cheng Zhang, Hu Li, Koo Jeong Kang, Lewis R. Roberts   +11 more
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Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. [PDF]

, 2012
Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53 ...
Eckhard Wolf, Marlene Edlinger, Marlene Edlinger (133272), Eckhard Wolf (39870), Krzysztof Flisikowski (133283), Mayuko Kurome, Claudia Merkl (133270), Kurome, Mayuko, Claudia Merkl, Alexander Kind, Valeri Zakhartchenko, Flisikowski, Krzysztof, Simon Leuchs (133268), Nousin Rezaei, Anja Saalfrank, Valeri Zakhartchenko (133278), Marina Durkovic (133273), Marina Durkovic, Krzysztof Flisikowski, Flisikowska, Tatiana, Kessler, Barbara, Saalfrank, Anja, Merkl, Claudia, Schnieke, Angelika, Simon Leuchs, Kind, Alexander, Zakhartchenko, Valeri, Barbara Kessler (133280), Alexander Kind (133287), Edlinger, Marlene, Mayuko Kurome (133277), Wolf, Eckhard, Rezaei, Nousin, Nousin Rezaei (133275), Angelika Schnieke (133290), Tatiana Flisikowska, Angelika Schnieke, Anja Saalfrank (133269), Tatiana Flisikowska (133271), Barbara Kessler, Leuchs, Simon, Durkovic, Marina   +41 more
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Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements [PDF]

, 2023
TP53 is a transcription factor that controls multiple cellular processes, including cell cycle arrest, DNA repair and apoptosis. The relation between TP53 binding site architecture and transcriptional output is still not fully understood.
Max Trauernicht, Chaitanya Rastogi, Rastogi, Chaitanya, Bussemaker, Harmen J, Bas van Steensel, Stefano G Manzo, van Steensel, Bas, Harmen J Bussemaker, Trauernicht, Max, Manzo, Stefano G   +9 more
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Retrospective and Randomized Analysis of Influence and Correlation of Clinical and Molecular Prognostic Factors in a Mono-Operative Series of 122 Patients with Glioblastoma Treated with STR or GTR

Brain Sciences, 2020
Glioblastoma is a solid, infiltrating, and the most frequent highly malignant primary brain tumor. Our aim was to find the correlation between sex, age, preoperative Karnofsky performance status (KPS), presenting with seizures, and extent of resection ...
Maurizio Salvati, Placido Bruzzaniti, Michela Relucenti, Mariagrazia Nizzola, Pietro Familiari, Marco Giugliano, Anthony Kevin Scafa, Santi Galletta, Xiaobo Li, Rui Chen, Claudio Barbaranelli, Alessandro Frati, Antonio Santoro   +12 more
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Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses [PDF]

, 2021
TP53 mutations are implicated in the progression of mucinous borderline tumors (MBOT) to mucinous ovarian carcinomas (MOC). Optimized immunohistochemistry (INC) for TP53 has been established as a proxy for the TP53 mutation status in other ovarian tumor ...
Bowtell, D. D. L., Antill, Y. C., Rowley, S., Provencher, D. M., Wakefield, M. J., Mateoiu, Constantina,, Le, N. D., LePage, C., Goodman, M. T., Kobel, M., Kang, E. Y., Ramus, S. J., Gourley, C., Sieh, W., Meagher, N. S., Deen, S., Anglesio, M. S., Gorringe, K. L., Gilks, C. B., Rahimi, K., Goode, E. L., Scott, C. L., Fasching, P. A., Huntsman, D. G., Cheasley, D., Salazar, C., Stephens, A. N., Sundfeldt, Karin,, Allan, P., Campbell, I., Pharoah, P. D. P., DeFazio, A., Mes-Masson, A. M., Cook, L. S., Brenton, J. D., Traficante, N., Kaufmann, S., Xing, Z. Y., Churchman, M., Torres, M. D., Kennedy, C. J., Kelemen, L. E., Doherty, J. A.   +42 more
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CDK4/6 inhibition in cancer: the cell cycle splicing connection

Molecular & Cellular Oncology, 2019
Cyclin-dependent kinase −4 and −6 (CDK4/6) inhibitors are currently being assessed in clinical trials for the treatment of many cancers including melanoma.
Karen E. Sheppard, Shatha AbuHammad
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A novel optical biosensor format for the detection of clinically relevant TP53 mutations [PDF]

, 2005
The TP53 gene has been the subject of intense research since the realisation that inactivation of this gene is common to most cancer types. Numerous publications have linked TP53 mutations in general or at specific locations to patient prognosis and ...
Mascini, Marco, Turner, Anthony P. F., P. WILSON, T. JIANG, Wilson, PK,, A. P. F. TURNER, Minunni, Maria, Wilson, P. K., Minunni, Maria E., Minunni, ME,, Jiang, T,, Turner, A P F,, Mascini, M,, Jiang, T.   +13 more
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Genomic context and TP53 allele frequency define clinical outcomes in TP53-mutated myelodysplastic syndromes [PDF]

, 2020
TP53 mutations are associated with adverse outcomes and shorter response to hypomethylating agents (HMAs) in myelodysplastic syndrome (MDS). Limited data have evaluated the impact of the type, number, and patterns of TP53 mutations in response outcomes ...
Kantarjian, Hagop, Naqvi, Kiran, Patel, Keyur P., Ravandi, Farhad, Benton, Christopher B., Sasaki ,, Koji, Garcia-Manero, Guillermo, Konopleva, Marina, Daver, Naval, Borthakur, Gautham, Montalban-Bravo, Guillermo, Jabbour, Elias, Class, Caleb A, Chien, Kelly S., Kadia, Tapan M., Bueso-Ramos, Carlos E., Pierce, Sherry R., Alvarado, Yesid, Takahashi, Koichi, Soltysiak, Kelly A., Pemmaraju, Naveen, Kanagal-Shamanna, Rashmi   +21 more
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