Results 11 to 20 of about 141,956 (266)
TP53 in Myelodysplastic Syndromes [PDF]
Cancers, 2021 Myelodysplastic syndromes (MDSs) are heterogeneous for their morphology, clinical characteristics, survival of patients, and evolution to acute myeloid leukemia. Different prognostic scoring systems including the International Prognostic Scoring System (IPSS), the Revised IPSS, the WHO Typed Prognostic Scoring System, and the Lower-Risk Prognostic ...
Yan Jiang +5 more
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The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis [PDF]
Nucleic Acids Research, 2012 A novel resource centre for TP53 mutations and mutants has been developed (http://p53.fr). TP53 gene dysfunction can be found in the majority of human cancer types. The potential use of TP53 mutation as a biomarker for clinical studies or exposome analysis has led to the publication of thousands of reports describing the TP53 gene status in >10,000 ...
Bernard Leroy +6 more
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TP53: an oncogene in disguise [PDF]
Cell Death & Differentiation, 2015 The standard classification used to define the various cancer genes confines tumor protein p53 (TP53) to the role of a tumor suppressor gene. However, it is now an indisputable fact that many p53 mutants act as oncogenic proteins. This statement is based on multiple arguments including the mutation signature of the TP53 gene in human cancer, the ...
Soussi, T, Wiman, K G
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Methylation of p53-responsive oncosuppressive microRNA genes in hemoblastosis
Сибирский онкологический журнал, 2022 The purpose of the study was to present up-to-date data on the frequency and significance of a number of p53-responsive oncosuppressive micrornas genes methylation in malignant neoplasms of the blood system.Material and methods.
E. N. Voropaeva +5 more
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The TP53 fertility network [PDF]
Genetics and Molecular Biology, 2012 The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed "guardian of the genome", TP53 occupies a central node in stress response networks.
Paskulin, Diego d'Avila +4 more
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TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
BMC Genomic Data, 2022 Abstract Background TP53 is rarely mutated in paediatric neuroblastoma. The prognosis of TP53 and TP53-associated genes in paediatric neuroblastoma is unclear. The objectives of the study were to analyse datasets of 2477 paediatric neuroblastoma patients from eight independent cohorts to reveal the prognosis of TP53 and ...
Haiwei Wang +3 more
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Liver Cancer, 2021 Introduction: Serum α-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-γ-carboxyprothrombin (DCP) are useful biomarkers of hepatocellular carcinoma (HCC).
Keun Soo Ahn +11 more
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Human Mutation, 2003 Ovarian cancer represents the fourth most frequent type of cancer among females and is the leading cause of death from gynecological cancer in the western world. This review describes gene alterations in ovarian cancer. Specific emphasis is placed on genetic alterations and the prevalence of TP53 (p53) gene alterations in the distinct biological ...
Monique, Schuijer, Els M J J, Berns
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Brain Sciences, 2020 Glioblastoma is a solid, infiltrating, and the most frequent highly malignant primary brain tumor. Our aim was to find the correlation between sex, age, preoperative Karnofsky performance status (KPS), presenting with seizures, and extent of resection ...
Maurizio Salvati +12 more
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Trends in Cell Biology, 2017 Identified as a TP53-binding protein, 53BP1 is a key regulator of the cellular response to double-strand breaks, a TP53-independent activity. Recent data have established a new TP53-dependent function for 53BP1 in mitotic surveillance after centrosome loss.
Soussi, Thierry, Kroemer, Guido
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