Results 21 to 30 of about 240,433 (353)

A Computational Model of Tumor Growth and Anakoinosis

Frontiers in Pharmacology, 2019
Anakoinosis is a new cancer treatment paradigm that posits a key role for communicative reprogramming within tumor systems. To date no mathematical or computational models of anakoinosis have been developed.
Pan Pantziarka, Pan Pantziarka, Lina Ghibelli, Albrecht Reichle   +3 more
doaj   +1 more source

Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis

Molecular Oncology, 2022
In humans, germline TP53 mutations predispose carriers to a wide spectrum of cancers, which is known as Li–Fraumeni syndrome (LFS). To date, the association of melanomas with LFS remains unestablished.
Rensen Ran, Lanxin Li, Zhaoying Shi, Guanghui Liu, Hao Jiang, Liangchen Fang, Tingting Xu, Jixuan Huang, Weiqi Chen, Yonglong Chen   +9 more
doaj   +1 more source

Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP

Cancer Biology & Medicine, 2022
Objective: Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma (DLBCL) are available.
Yan Qin, Haizhu Chen, Peng Liu, Changgong Zhang, Jianliang Yang, Lin Gui, Xiaohui He, Liqiang Zhou, Shengyu Zhou, Shiyu Jiang, Hongxin Jiang, Yuankai Shi   +11 more
doaj   +1 more source

The Expression Levels of XLF and Mutant P53 Are Inversely Correlated in Head and Neck Cancer Cells. [PDF]

, 2016
XRCC4-like factor (XLF), also known as Cernunnos, is a protein encoded by the human NHEJ1 gene and an important repair factor for DNA double-strand breaks.
Chen, Wei, Feng, Sizhe, Guo, Mian, Hu, Shen, Liang, Guobiao, Messadi, Diana, Rabii, Ramin, Song, Chenxi, Wei, Xuezhong   +8 more
core   +2 more sources

Methylation of p53-responsive oncosuppressive microRNA genes in hemoblastosis

Сибирский онкологический журнал, 2022
The purpose of the study was to present up-to-date data on the frequency and significance of a number of p53-responsive oncosuppressive micrornas genes methylation in malignant neoplasms of the blood system.Material and methods.
E. N. Voropaeva, T. I. Pospelova, O. V. Berezina, M. I. Churkina, A. A. Gurazheva, V. N. Maksimov   +5 more
doaj   +1 more source

The TP53 fertility network [PDF]

Genetics and Molecular Biology, 2012
The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed "guardian of the genome", TP53 occupies a central node in stress response networks.
Paskulin, Diego d'Avila, Paixão-Côrtes, Vanessa Rodrigues, Hainaut, Pierre, Bortolini, Maria Cátira, Ashton-Prolla, Patricia   +4 more
openaire   +7 more sources

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas [PDF]

, 2018
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Alvaro, Domenico, Andrew D, Cherniack, Bin, Feng, Bragazzi, MARIA CONSIGLIA, Cardinale, Vincenzo, Casey S, Greene, Chase, Miller, Chen, Wang, Christina, Yau, David A, Wheeler, Denise, Wolf, Eve, Shinbrot, Galen F, Gao, Gaudio, Eugenio, Gordon B, Mills, Gregory P, Way, Hai, Hu, Haoran, Chen, Hui, Shen, Huihui, Fan, Ilya, Shmulevich, Jianfang, Liu, John N, Weinstein, Lawrence A, Donehower, Lei, Li, Li, Ding, Linghua, Wang, Matthew H, Bailey, Michael T, Zimmermann, Mostafa, Karimi, Nyasha, Chambwe, Peilin, Jia, Peter W, Laird, Pora, Kim, Raymond J, Monnat, Rehan, Akbani, Shaojun, Zhang, Theo A, Knijnenburg, Yang, Shen, Yonghong, Xiao, Yuexin, Liu, Zhongming, Zhao   +41 more
core   +1 more source

TP53 and 53BP1 Reunited [PDF]

Trends in Cell Biology, 2017
Identified as a TP53-binding protein, 53BP1 is a key regulator of the cellular response to double-strand breaks, a TP53-independent activity. Recent data have established a new TP53-dependent function for 53BP1 in mitotic surveillance after centrosome loss.
Soussi, Thierry, Kroemer, Guido
openaire   +2 more sources

Associations of Serum Tumor Biomarkers with Integrated Genomic and Clinical Characteristics of Hepatocellular Carcinoma

Liver Cancer, 2021
Introduction: Serum α-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-γ-carboxy­pro­thrombin (DCP) are useful biomarkers of hepatocellular carcinoma (HCC).
Keun Soo Ahn, Daniel R. O’Brien, Yong Hoon Kim, Tae-Seok Kim, Hiroyuki Yamada, Joong-Won Park, Sang-Jae Park, Seoung Hoon Kim, Cheng Zhang, Hu Li, Koo Jeong Kang, Lewis R. Roberts   +11 more
doaj   +1 more source

Retrospective and Randomized Analysis of Influence and Correlation of Clinical and Molecular Prognostic Factors in a Mono-Operative Series of 122 Patients with Glioblastoma Treated with STR or GTR

Brain Sciences, 2020
Glioblastoma is a solid, infiltrating, and the most frequent highly malignant primary brain tumor. Our aim was to find the correlation between sex, age, preoperative Karnofsky performance status (KPS), presenting with seizures, and extent of resection ...
Maurizio Salvati, Placido Bruzzaniti, Michela Relucenti, Mariagrazia Nizzola, Pietro Familiari, Marco Giugliano, Anthony Kevin Scafa, Santi Galletta, Xiaobo Li, Rui Chen, Claudio Barbaranelli, Alessandro Frati, Antonio Santoro   +12 more
doaj   +1 more source