Results 41 to 50 of about 179,934 (163)

The Efficacy and Safety of PD-1 Inhibitors Combined with Nab-Paclitaxel Plus Gemcitabine versus Nab-Paclitaxel Plus Gemcitabine in the First-Line Treatment of Advanced Pancreatic Cancer: A Retrospective Monocentric Study

Cancer Management and Research, 2022
Feng Zhang, Yuyang Wang, Fangfang Yang, Yuming Zhang, Man Jiang,* Xiaochun Zhang* Precision Medicine Center of Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, People’s Republic of China*These ...
Zhang F, Wang Y, Yang F, Zhang Y, Jiang M, Zhang X   +5 more
doaj  

Comprehensive Identification of Deleterious TP53 Missense VUS Variants Based on Their Impact on TP53 Structural Stability

, 2021
TP53 plays critical roles in maintaining genome stability. Deleterious genetic variants damage the function of TP53, causing genome instability and increased cancer risk.
Zixin Qin, San Ming Wang, Siddharth Sinha, Benjamin Tam   +3 more
core   +1 more source

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis

, 2013
International audienceA novel resource centre for TP53 mutations and mutants has been developed (http://p53.fr). TP53 gene dysfunction can be found in the majority of human cancer types.
Leroy, B, Leroy, Bernard, Ishioka, Chikashi, Ishioka, C, Fournier, Jean Louis, Fronza, Gilberto, Fronza, G, Inga, Alberto, Monti, P, Fournier, JL, Soussi, T,, Monti, Paola, Soussi, Thierry, Inga, A   +13 more
core   +1 more source

Presence and prevalence of single nucleotide sequence polymorphisms in TP53 and BRCA2 genes as of cervical and ovarian cancers in women using hormonal contraceptives in Abuja, Nigeria

Journal of Public Health in Africa
Background: Cancer remains a major health burden in sub-Saharan Africa, characterised by high incidence and mortality rates as a result of late diagnosis, limited access to treatment and poor outcomes.
Omorinsola F. Odebiyi, Adedapo Kehinde, Mohammed S. Abdulsalami, Deborah M. Dibal   +3 more
doaj   +1 more source

Expression of TOPⅡα, TP53 and HER2 in Gastric Adenocarcinoma and Their Clinical Significance

Zhongliu Fangzhi Yanjiu, 2018
Objective To detect the expression of TOPⅡα, TP53 and HER2 in gastric adenocarcinoma tissuses, and to explore their inner relationship as well as their relationship with the clinicopathological characteristics of gastric adenocarcinoma patients.
MA Yihui, WANG Qingjie, GAO Hanqing, WANG Feng, CHEN Kuisheng   +4 more
doaj   +1 more source

The Ribosomal Protein L5 Functions During Xenopus Anterior Development Through Apoptotic Pathways

Frontiers in Cell and Developmental Biology, 2022
Ribosomal biogenesis is a fundamental process necessary for cell growth and division. Ribosomal protein L5 (Rpl5) is part of the large ribosomal subunit.
Corinna Schreiner, Corinna Schreiner, Bianka Kernl, Bianka Kernl, Petra Dietmann, Ricarda J. Riegger, Michael Kühl, Susanne J. Kühl   +7 more
doaj   +1 more source

[Correspondence] Breast-cancer stromal cells with TP53 mutations

, 2008
To the Editor\ud \ud Patocs et al. (Dec. 20, 2007, issue)1 report a frequency of TP53 mutations in fibroblasts associated with sporadic breast carcinoma of 27.4%, and they show that mutation status is associated with regional nodal metastasis.
Cai, L., Allinen, M., Lebret, S.C., Thompson, E.W., Zhang, L., Patocs, A., Beroukhim, R.   +6 more
core   +1 more source

The presence of Y674/Y675 phosphorylated NTRK1 via TP53 repression of PTPN6 expression as a potential prognostic marker in neuroblastoma [PDF]

, 2019
The tumor suppressor TP53 promotes nerve growth factor receptor (NTRK1) -Y674/Y675 phosphorylation (NTRK1-pY674/pY675) via repression of the NTRK1 phosphatase PTPN6 in a ligand-independent manner, resulting in suppression of breast cancer cell ...
Rampling, D., Sebire, Neil, Barton, Jack, Edwards, Darren, Anderson, J., Virasami, Alex, Gillett, C., Youssef, Gehad, Virasami, A., Montano, X., Chagtai, T., Anderson, John, Barton, J., Rampling, Dyanne, Chagtai, Tasnim, Youssef, G., Gillett, Cheryl, Edwards, D., Sebire, N., Montano, Ximena   +19 more
core   +1 more source

CTCs Detection and Whole-exome Sequencing Might Be Used to Differentiate Benign and Malignant Pulmonary Nodules

Chinese Journal of Lung Cancer, 2023
Background and objective Low-density computed tomography (LDCT) improved early lung cancer diagnosis but introduces an excess of false-positive pulmonary nodules data. Hence, accurate diagnosis of early-stage lung cancer remains challenging.
Changdan XU, Xiaohong XU, Weipeng SHAO, Hongliang SUN, Xiaohong LIU, Hongxiang FENG, Xianbo ZUO, Jingyang GAO, Guohui WANG, Xiongtao YANG, Runchuan GU, Shutong GE, Shijie WANG, Liwei GAO, Guangying ZHU   +14 more
doaj   +1 more source

TP53 and 53BP1 Reunited

, 2017
International audienceIdentified as a TP53-binding protein, 53BP1 is a key regulator of the cellular response to double-strand breaks, a TP53-independent activity.
Soussi, Thierry, Kroemer, Guido
core   +1 more source