Results 31 to 40 of about 179,934 (163)

Impact of TP53 mutations on the efficacy of CAR-T cell therapy in cancer

Exploration of Immunology
The efficacy of chimeric antigen receptor (CAR)-T therapy may not match initial expectations due to the influence of multiple circumstances, some of which cannot be predicted.
Regina Mirgayazova, Raniya Khadiullina, Maria Filimonova, Vitaly Chasov, Emil Bulatov   +4 more
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TP53 rs1042522 polymorphism and early-onset breast cancer

Journal of Research in Medical Sciences, 2020
Background: Breast cancer is the leading cause of cancer deaths among women. Early-onset breast cancer is well recognized as it clinically differs from old-age diagnosed breast neoplasms.
Irmak Icen-Taskin, Sevgi Irtegun-Kandemir, Omer Munzuroglu   +2 more
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TP53 mutation.

, 2022
TP53 mutation.
Vania Myralda Giamour Marbun (12884117), Toar Jean Maurice Lalisang (12884120), Linda Erlina (9914846)   +2 more
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MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer

Cancer Biology & Medicine
Objective: Identifying biomarkers that predict the efficacy and prognosis of chemoradiotherapy is important for individualized clinical treatment. We previously reported that high murine double minute 1 (MDM1) expression in patients with rectal cancer is
Ningxin Ren, Hongxia Chen, Ying Huang, Jing Jin, Shaosen Zhang, Ruoqing Yan, Mengjie Li, Linlin Zheng, Shuangmei Zou, Yexiong Li, Wen Tan, Dongxin Lin   +11 more
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Pathological Characteristics of Mutations in PIK3CA and TP53 Genes in Breast Cancer Cases from Qinghai Area

Zhongliu Fangzhi Yanjiu
ObjectiveTo analyze ethnic differences in mutations of the PIK3CA and TP53 genes among breast cancer patients from the Han, Tibetan, and Hui ethnic groups in Qinghai, China, and their associations with clinicopathological characteristics.
Xueyue LI, Jing HU, Hongyuan LIAO, Haiqin ZHANG, Xiude LI, Hao LEI, Xiaofeng ZHOU   +6 more
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Cellular Mechanism of Gene Mutations and Potential Therapeutic Targets in Ovarian Cancer

Cancer Management and Research, 2021
Tao Guo,1 Xue Dong,2 Shanli Xie,3 Ling Zhang,4 Peibin Zeng,5 Lin Zhang6 1Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China; 2Department of Gynecology, Cheng
Guo T, Dong X, Xie S, Zhang L, Zeng P, Zhang L   +5 more
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Two Subsequent Metachroneus Solid Tumors: Oncocytic Variant Adrenocortical Carcinoma and Rhabdomyosarcoma of Childhood: Case Report and Literature Review

JCRPE, 2021
Most cases of malignancies appear to be sporadic, but some syndromes are associated with malignancies with germline variants. Herein, a child with an unusual association of oncocytic variant adrenocortical carcinoma (ACC) and rhabdomyosarcoma (RMS) was ...
Onur Akin, Erman Atas, İrem Ayşe Atasoy, Nihal Durmaz, Ömer Kartal   +4 more
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TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype

, 2008
Presence of TP53 mutations has been associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), although this has remained controversial.
Amini, Rose-Marie, Berglund, Mattias, Enblad, Gunilla, Roos, G, Rosenquist, Richard, Ren, Zhi-Ping, Berglund, M,, Lindell, Monica, Wanders, Alkwin, Berglund, Mattias,, Kanduri, M, Zainuddin, Norafiza,, Kanduri, Meena, Amini, Rose-Marie,, Rosenquist, R, Roos, Göran, Ren, Z-P, Enblad, Gunilla,, Lindell, M, Lindell, Monica,, Kanduri, Meena,, Wanders, A, Zainuddin, Norafiza, Ren, Zhi-Ping,, Zainuddin, N, Wanders, Alkwin,, Rosenquist, Richard,, Roos, Göran,, Enblad, G, Amini, R-M   +29 more
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TP53 Combined Phenotype Score Is Associated with the Clinical Outcome of TP53-Mutated Myelodysplastic Syndromes

, 2021
Mutations of TP53 are observed in 5–10% of patients in myelodysplastic syndrome (MDS) and are associated with adverse outcomes. Previous studies indicate that the TP53 allelic state and variant allele frequency of TP53 mutation impact patient outcomes ...
Meier Hsu, Andrew M. Brunner, Aidana Z. Omarbekova, Hannah May, Ying Liu, Mariko Yabe, Maria E. Arcila, Robert P. Hasserjian, Virginia M. Klimek, Valentina Nardi, Ahmet Dogan   +10 more
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بررسی جهش در اگزو نهای پنج تا هشت ژن TP53 در بیماران آذری مبتلا به سرطان تیروئید تک گیر [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2018
چکیده:سابقه و هدف : سرطان تیروئید شایع‌ترین بدخیمی سیستم اندوکرینی است. سرطان تیروئید در هر سن و جنس می‌تواند رخ دهد. از مهمترین ژن‌های سرکوبگر درگیر در سرطان، ژن TP53 می‌باشد. که در تنظیم و توقف چرخه سلولی و اپوتپوز نقش مهمی دارد.
ناصر پولادی, محمدعلی حسینپور فیضی   +1 more
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