Results 51 to 60 of about 179,934 (163)

Germline mutations of TP53 gene can be a key factor in prostate cancer genesis

Exploration of Medicine
Aim: The aim of this study is to investigate whether germline alterations of exon 5 of TP53 gene could be detected in the blood of known men with prostate cancer and to assess the potential association between the genomic alteration affecting this gene ...
Kawtar Aboulalaa, Abdelilah Laraqui, Reda Tagajdid, Khalid Ennibi, Moulay Mustapha Ennaji   +4 more
doaj   +1 more source

TP53 Mutations Identified Using NGS Comprise the Overwhelming Majority of TP53 Disruptions in CLL: Results From a Multicentre Study

, 2022
Limited data exists to show the correlation of (tumour protein 53) TP53 mutation detected by Next generation sequencing (NGS) and the presence/absence of deletions of 17p13 detected by FISH. The study which is the largest series to date includes 2332 CLL
Iyengar, Sunil, Donaldson, David, Hayat, Amjad, Cross, Nicholas C. P., Sargent, Jeremy, Mills, Ken, de Castro, David Gonzalez, Mills, Ken; id_orcid, Lawless, Sarah, Wren, Dorte, Quinn, John, Stewart, Peter, ElHassadi, Ezzat, Maurya, Manisha, Thornton, Patrick, Cavalieri, Doriane, Murphy, Philip, O’Shea, Derville, Forconi, Francesco, Catherwood, Mark A., Schuh, Anna, Chiecchio, Laura, Cahill, Mary R.   +22 more
core   +1 more source

MiR-21, miR-34a, miR-125b, miR-181d and miR-648 levels inversely correlate with MGMT and TP53 expression in primary glioblastoma patients

Archives of Medical Science, 2019
Introduction TP53 and MGMT alterations play a crucial role in glioblastoma (GB) pathogenesis. TP53 and MGMT function is affected by several pathologic mechanisms, such as point mutations or promoter methylation, which are well characterized.
Dorota Jesionek-Kupnicka, Marcin Braun, Berenika Trąbska-Kluch, Joanna Czech, Małgorzata Szybka, Bożena Szymańska, Dominika Kulczycka-Wojdala, Michał Bieńkowski, Radzisław Kordek, Izabela Zawlik   +9 more
doaj   +1 more source

CD80 expression is upregulated by TP53 activation in human cancer epithelial cells

OncoImmunology, 2021
CD80 is recognized as one of the most potent costimulatory molecules by which immune cells limit cancer progression; however, the current understanding of the regulation of its expression on human tumor cells is limited. The TP53 tumor suppressor plays a
Melania Scarpa, Chiara Marchiori, Marco Scarpa, Ignazio Castagliuolo   +3 more
doaj   +1 more source

TP53 expression in MLS/RCLS.

, 2014
(A) Immunohistochemistry analysis of TP53 expression in a representative MLS/RCLS case. Inset shows TP53 mutated endometrial carcinoma as positive control. Brown precipitate indicates TP53 expression. Scale bar shows 100 µm.
Christina Kåbjörn Gustafsson (660003), Katarina Engtröm (660004), Shiaw-Min Chen (660008), Christer Thomsen (172629), Soheila Dolatabadi (660005), Pierre Åman (86136), Anders Ståhlberg (51867), Emma Jonasson (660006), David Ruff (660007), Chieh-Yuan Li (173019)   +9 more
core   +1 more source

Macrotrabecular-Massive Hepatocellular Carcinoma: Light and Shadow in Current Knowledge

Journal of Hepatocellular Carcinoma, 2022
Anna Sessa,1– 3 Sébastien Mulé,2– 4 Raffaele Brustia,2,3,5 Hélène Regnault,1,3 Athena Galletto Pregliasco,4 Rami Rhaiem,6,7 Vincent Leroy,1– 3 Daniele Sommacale,2,3,5 Alain Luciani,2– 4 Julien Calderaro,2,3,8 Giuliana Amaddeo1– 3 1Hepatology Department ...
Sessa A, Mulé S, Brustia R, Regnault H, Galletto Pregliasco A, Rhaiem R, Leroy V, Sommacale D, Luciani A, Calderaro J, Amaddeo G   +10 more
doaj  

Histone deacetylase inhibitors cause TP53-dependent induction of p21/Waf1 in tumor cells with TP53 mutations

, 2015
The p21/Waf1 protein is one of the main regulators of cell cycle arrest and one of the best-known transcriptional targets of the TP53 protein. Here, we demonstrated that there is activation of expression of the p21/Waf1 gene when the cells were treated ...
Volnitskiy, AV, Kovalev, RA, Karelov, DV, Makarov, EM, Filatova, MV, Shtam, TA, Burdakov, VS   +6 more
core   +1 more source

A Database of Drug Repurposing Clinical Trials in Oncology

Frontiers in Pharmacology, 2021
Pan Pantziarka, Pan Pantziarka, Liese Vandeborne, Gauthier Bouche   +3 more
doaj   +1 more source

Theorem representing the regulatory loop involving MDM2, MDM2 and TP53 and leading to TP53 degradation: TP53& TP53& MDM2& U& P ⊢ d(TP53).

, 2013
It is known that TP53, the well-known tumor suppressor [22] binds to the MDM2 gene and activates its transcription, ultimately leading synthesis of the MDM2 protein [23], [28].
Marcello D'Agostino (366699), Pier Paolo Di Fiore (46600), Giovanni Boniolo (366698)   +2 more
core   +1 more source