Results 71 to 80 of about 179,934 (163)

Цитогенетические повреждения и эпигенетический статус промоторов генов TP53, BRCA1 и ERCC2 у работников угольных предприятий [PDF]

Письма в Вавиловский журнал генетики и селекции
Человек подвергается воздействию различных химических соединений на протяжении жизни, однако профессиональная специализация обуславливает наиболее опасное воздействие на организм. Важной проблемой является понимание влияния промышленной среды на геномную
Марущак А.В, Астафьева М.В, Глушков А.Н., Минина В.И.   +3 more
doaj   +1 more source

TP53 mutation (cont.).

, 2022
TP53 mutation (cont.).
Vania Myralda Giamour Marbun (12884117), Toar Jean Maurice Lalisang (12884120), Linda Erlina (9914846)   +2 more
core   +1 more source

Effects of Tp53 Gene Mutations on the Survival of Non-Small Cell Lung Cancer (NSCLC); A Short Review [PDF]

Chi Zhang,1,2,* Chao Yang,3,* Qingming Shi1,2 1Department of Oncology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China; 2Anhui Medical University Clinical College of Chest, Hefei, 230022, People’s Republic of China; 3Department of
Shi Q, Zhang C, Yang C
core  

Mutations in TP53 interface predict patient's outcomes.

, 2015
a) Our analysis identified the interface between TP53 and SV40 (shown in gray and orange respectively) as strongly enriched in mutations (panel c). b) This interface is the same as the one that TP53 uses to interact with other TP53 molecules (shown in ...
Luz Garcia-Alonso (815938), Joaquin Dopazo (5763), Eduard Porta-Pardo (815937), Thomas Hrabe (815939), Adam Godzik (4285)   +4 more
core   +1 more source

HSPA9 and TP53 interact in CD34+ cells and HSPA9 knockdown increases nuclear TP53 levels.

, 2017
(A) Representative immunoblots of TP53 and HSPA9 following immunoprecipitation with anti-TP53 or an IgG control. (B) Representative immunoblots of TP53 from the cytoplasmic and nuclear fractions of cell lysates following knockdown of HSPA9 in CD34+ cells
Sanghyun Kim (515612), Cara Lunn Shirai (3727078), Kilannin Krysiak (2380666), Tuoen Liu (3147423), Jin Shao (266803), Matthew Ndonwi (3727075), Matthew J. Walter (266835)   +6 more
core   +1 more source

Exploring the role of splicing in TP53 variant pathogenicity through predictions and minigene assays

Background TP53 variant classification benefits from the availability of large-scale functional data for missense variants generated using cDNA-based assays.
Elena Bueno-Martínez, Eladio A. Velasco-Sampedro, Fortuno, C, Caldes, Sonsoles, Bueno-Martínez, Elena, Cristina Fortuno, Sanoguera-Miralles, L, James, Paul, Lara Sanoguera-Miralles, Bueno-Martínez, E, Hoya, Miguel de la, Sonsoles Caldes, Canson, D., Miguel de la Hoya, Spurdle, Amanda B., Velasco-Sampedro, EA, Llinares-Burguet, Inés, James, PA, Spurdle, AB, Inés Llinares-Burguet, Fortuno, C., Velasco, Eladio, Sanoguera-Miralles, Lara, Daffodil M. Canson, de la Hoya, M, Amanda B. Spurdle, Paul A. James, Llinares-Burguet, I, Canson, DM, Caldes, S   +29 more
core   +1 more source

Induction of the phosphorylation of TP53 at Ser46 and the accumulation of transcripts of the genes targeted by TP53, which participate in TP53-mediated apoptosis.

, 2014
(A) Immunoblotting in OVMANA cells treated with DS-7423 at the indicated doses. Phosphorylation levels of MDM2 were inversely associated with p-TP53 at Ser46, but not with p-TP53 at Ser15.
Tomoko Kashiyama (162572), Chinami Makii (519511), Kenbun Sone (162596), Takahiro Koso (162616), Tomoyuki Fujii (276627), Kanako Inaba (519510), Michihiro Tanikawa (162611), Keiko Shoji (162558), Koichi Matsuda (135032), Yuji Ikeda (162580), Frank McCormick (36943), Aki Miyasaka (162613), Osamu Wada-Hiraike (162623), Tomohiko Fukuda (519513), Tetsu Yano (162636), Yoshinobu Shiose (519508), Yasuhide Hirota (519509), Katsutoshi Oda (162567), Takahide Arimoto (456512), Hiroyuki Aburatani (162634), Reiko Kurikawa (519512), Shunsuke Nakagawa (162587), Kei Kawana (162627), Yutaka Osuga (456513)   +23 more
core   +1 more source

Unraveling the Role of TP53 in Colorectal Cancer Therapy: From Wild-Type Regulation to Mutant

Frontiers in Bioscience-Landmark
The p53, a pivotal tumor suppressor, regulates various cellular responses, including DNA repair and apoptosis. Normally, p53 levels are low due to murine double minute clone 2 (MDM2) mediated polyubiquitination.
Wenshu Li, Longyuan Li, Huan Yang, Chenxi Shi, Zhe Lei, Lingchuan Guo, Yuhong Wang   +6 more
doaj   +1 more source

Somatiske TP53-mutasjoner i brystkreft [PDF]

, 2014
Background: Mutations in tumor suppressor genes may facilitate malignant transformation of cells. A TP53 mutation is the most common genetic alteration in breast cancer, and is found in approximately 25 % of breast tumors.
Dahl, Kamilla Haug
core  

TP53: an oncogene in disguise

, 2015
International audienceThe standard classification used to define the various cancer genes confines tumor protein p53 (TP53) to the role of a tumor suppressor gene.
Wiman, K G, T Soussi, Wiman, KG, Soussi, T,, K G Wiman, Soussi, T   +5 more
core   +1 more source