Results 61 to 70 of about 179,934 (163)
Turkish Journal of Hematology, 2017 Objective: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disease in adults. The aim of this study is to find out if the extent of proliferation centers or the immunohistochemical expression of p53 is related to disease ...
İbrahim Kulaç +4 more
doaj +1 more source
Characteristics and Management of TP53-Mutated Diffuse Large B-Cell Lymphoma Patients
Cancer Management and Research, 2020 Yan Qin,1,* Shiyu Jiang,1,* Peng Liu,1 Jianliang Yang,1 Sheng Yang,1 Xiaohui He,1 Shengyu Zhou,1 Lin Gui,1 Jing Lin,2 Xinhua Du,3 Yuting Yi,3 Yan Sun,1 Yuankai Shi1 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center
Qin Y +12 more
doaj
A role for p53 in telomere protection
Molecular & Cellular Oncology, 2017 Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
doaj +1 more source
Current Issues in Carcinogenesis
Клиническая онкогематология, 2019 The review presents current data on the major pathogenetic mechanisms underlying uncontrolled growth and dissemination of tumor and its resistance to conventional treatment.
Irina Viktorovna Vysotskaya +5 more
doaj +1 more source
TP53 Mutations in Nonsmall Cell Lung Cancer [PDF]
, 2011 The tumor suppressor gene TP53 is frequently mutated in human cancers. Abnormality of the TP53 gene is one of the most significant events in lung cancers and plays an important role in the tumorigenesis of lung epithelial cells.
Akira Mogi, Hiroyuki Kuwano
core +1 more source
Integrating mutation variant allele frequency into clinical practice in myeloid malignancies
Hematology/Oncology and Stem Cell Therapy, 2016 Hematologic myeloid neoplasms represent a heterogeneous group of disorders with defined clinical and pathologic characteristics. However, intensive investigation into the genetic abnormalities of these diseases has not only significantly advanced our ...
David A. Sallman, Eric Padron
doaj +1 more source
A Molecular and Computational Study on the Effects of 5-Fluorouracil, and Dicyclomine on AGS Cells: Regulation of P53 and SNAIL2 Pathways [PDF]
Pharmaceutical SciencesBackground: 5-Fluorouracil (5-FU) is commonly used to inhibit gastric cancer (GC) cell growth, but its clinical effectiveness is frequently limited by chemoresistance.
Fariba Ghodrati +7 more
doaj +1 more source
, 2018 Zhiyong Dong,1,2,* Longzhi Zheng,2,* Weimin Liu,1 Cunchuan Wang1 1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China; 2Department of Surgery, The Affiliated Hospital of Putian University, Putian ...
Dong ZY, Wang C, Zheng L, Liu W
core
, 2020 Norway For the p53 Special Issue The TP53 gene (p53) is found altered in breast carcinomas in approximately 20-40% of all cases depending on tumor size and stage of the disease. It seems to be an early event in breast tumorigenesis. Several polymorphisms
Anne-Lise Brresen-Dale
core
Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis.
, 2021 a, Cancer dependency map (DepMap) data for ARID1A wild-type cell lines, measuring ARID1A knockout viability effect on TP53 wild-type vs. mutant lines. Statistic is unpaired, two-tailed Wilcoxon test.
Ken Lin (9358913) +10 more
core +1 more source