Results 81 to 90 of about 179,934 (163)

Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

OncoImmunology, 2018
Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral cancer ...
Ellen C. Moore, Lillian Sun, Paul E. Clavijo, Jay Friedman, Joe B. Harford, Anthony D. Saleh, Carter Van Waes, Esther H. Chang, Clint T. Allen   +8 more
doaj   +1 more source

TP53 : the unluckiest of genes?

The transcription factor p53 plays a key role in the cellular defense against cancer development. It is inactivated in virtually every tumor, and in every second tumor this inactivation is due to a mutation in the TP53 gene.
Soussi, Thierry, Joerger, Andreas C., Stiewe, Thorsten   +2 more
core   +1 more source

The relevance of TP53 for CLL diagnostics

, 2019
TP53 disruption in Chronic Lymphocytic Leukaemia ha long been known to hold vital prognostic information as well as dictate the appropriate course of treatment to be followed for patients.
Thornton, Patrick D., Mills, Ken I.; id_orcid, Donaldson, David, Gonzalez de Castro, David, Catherwood, Mark A., Clifford, Ruth   +5 more
core   +1 more source

Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population

Central Asian Journal of Medical Sciences
Objective: Renal cell carcinoma (RCC) is one of the most common malignancies of the kidney, with genetic factors playing a critical role in its development.
Ganbayar Batmunkh, Munkhtuya Tumurkhuu, Myagmarsuren Purevsuren, Bayan-Undur Dagvadorj, Yerkyebulan Mukhtar, Tsogzolmaa Shiirevnyamba, Ganbolor Yura, Naranjargal Davaadorj, Shiirevnyamba Avirmed   +8 more
doaj   +1 more source

Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway [PDF]

TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity.
Nilsson, Jenny, Kovac, Michal, Baumhoer, Daniel, Saba, Karim H, Bidgoli, Mahtab, Cornmark, Louise, Nord, Karolin H, Magnusson, Linda, Staaf, Johan, Nathrath, Michaela, Foijer, Floris; id_orcid, van den Bos, Hilda, Spierings, Diana Cj, Jonson, Tord, Foijer, Floris, Difilippo, Valeria, Spierings, Diana C.J., Nord, Karolin H., Sumathi, Vaiyapuri P, Brosjö, Otte, Saba, Karim H., Styring, Emelie, Sumathi, Vaiyapuri P.   +22 more
core   +1 more source

TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia [PDF]

, 2014
Defects in the tumor suppressor gene TP53 are known to be important in chronic lymphocytic leukemia (CLL) and TP53 inactivation is associated with a particularly aggressive form of the disease. The single nucleotide polymorphism in the TP53 gene at codon
Bilous, N.I., Abramenko, I.V., Dyagil, I.S., Chumak, A.A., Martina, Z.V.   +4 more
core   +1 more source

TP53-Mutationsanalyse aggressiver Non-Hodgkin-Lymphome

, 2015
Bei einigen B-Non-Hodgkin-Lymphomen, u.a. der CLL, dem Mantelzell-Lymphom und dem DLBCL konnte die TP53-Mutation als unabhängiger Prognosefaktor bereits bestätigt werden.
Helfrich, Hanne
core   +1 more source

Review of prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology with morphological report and molecular analysis of 37-year-old man’s nephroblastoma

, 2017
Here we review prognostic and predictive aspects of mutated TP53 in Wilms’ tumor biology on the basis of the morphological report and molecular analysis of adult nephroblastoma (diffuse blastemal pattern) of a 37-year-old man.
Janusz Kopczyński, Artur Kowalik, Stanisław Sulkowski, Andrzej Wincewicz, Sebastian Zięba, Stanisław Góźdź   +5 more
core   +1 more source

Anticancer activity of Lavandula stoechas L. flower ethanolic extract through apoptotic pathway modulation in colorectal cancer cells

Acta Pharmaceutica
This study aimed to investigate the anticancer effects and underlying mechanisms of an ethanolic extract of Lavandula stoechas L. flowers (LsHE) on colorectal cancer.
Doğru Zeynep, Doğru Mustafa Selim, Yeşilay Gamze, Kayalar Özgecan, Elmastaş Mahfuz   +4 more
doaj   +1 more source

Mapping of TP53 protein network using cytoscape software

Pharmaceutical and Biomedical Research, 2018
TP53 acts as a tumor suppressor in cancer. It induces cell cycle arrest or apoptosis in response to cellular stress and damage. p53 gene alteration could cause uncontrolled cell proliferation.In the present study, we used TP53 gene as the seed in the ...
Asita Elengoe, Salehhuddin Hamdan
doaj