Results 11 to 20 of about 149,070 (296)
Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis
Molecular Oncology, 2022 In humans, germline TP53 mutations predispose carriers to a wide spectrum of cancers, which is known as Li–Fraumeni syndrome (LFS). To date, the association of melanomas with LFS remains unestablished.
Rensen Ran +9 more
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Cancer Biology & Medicine, 2022 Objective: Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma (DLBCL) are available.
Yan Qin +11 more
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Methylation of p53-responsive oncosuppressive microRNA genes in hemoblastosis
Сибирский онкологический журнал, 2022 The purpose of the study was to present up-to-date data on the frequency and significance of a number of p53-responsive oncosuppressive micrornas genes methylation in malignant neoplasms of the blood system.Material and methods.
E. N. Voropaeva +5 more
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The TP53 fertility network [PDF]
Genetics and Molecular Biology, 2012 The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed "guardian of the genome", TP53 occupies a central node in stress response networks.
Paskulin, Diego d'Avila +4 more
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Liver Cancer, 2021 Introduction: Serum α-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-γ-carboxyprothrombin (DCP) are useful biomarkers of hepatocellular carcinoma (HCC).
Keun Soo Ahn +11 more
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Trends in Cell Biology, 2017 Identified as a TP53-binding protein, 53BP1 is a key regulator of the cellular response to double-strand breaks, a TP53-independent activity. Recent data have established a new TP53-dependent function for 53BP1 in mitotic surveillance after centrosome loss.
Soussi, Thierry, Kroemer, Guido
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Brain Sciences, 2020 Glioblastoma is a solid, infiltrating, and the most frequent highly malignant primary brain tumor. Our aim was to find the correlation between sex, age, preoperative Karnofsky performance status (KPS), presenting with seizures, and extent of resection ...
Maurizio Salvati +12 more
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CDK4/6 inhibition in cancer: the cell cycle splicing connection
Molecular & Cellular Oncology, 2019 Cyclin-dependent kinase −4 and −6 (CDK4/6) inhibitors are currently being assessed in clinical trials for the treatment of many cancers including melanoma.
Karen E. Sheppard, Shatha AbuHammad
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The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis [PDF]
Nucleic Acids Research, 2012 A novel resource centre for TP53 mutations and mutants has been developed (http://p53.fr). TP53 gene dysfunction can be found in the majority of human cancer types. The potential use of TP53 mutation as a biomarker for clinical studies or exposome analysis has led to the publication of thousands of reports describing the TP53 gene status in >10,000 ...
Leroy, Bernard +6 more
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Human Mutation, 2003 Ovarian cancer represents the fourth most frequent type of cancer among females and is the leading cause of death from gynecological cancer in the western world. This review describes gene alterations in ovarian cancer. Specific emphasis is placed on genetic alterations and the prevalence of TP53 (p53) gene alterations in the distinct biological ...
Monique, Schuijer, Els M J J, Berns
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