Results 21 to 30 of about 149,070 (296)

Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma

OncoImmunology, 2021
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma with high mutation burdens but a low response rate to immune checkpoint inhibitors.
Hua You, Zijun Y. Xu-Monette, Li Wei, Harry Nunns, Máté L. Nagy, Govind Bhagat, Xiaosheng Fang, Feng Zhu, Carlo Visco, Alexandar Tzankov, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Fredrick B. Hagemeister, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Benjamin M. Parsons, J. Han Van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Qingyan Au, Bing Xu, Maher Albitar, Ken H. Young   +28 more
doaj   +1 more source

TP53 and liver carcinogenesis [PDF]

Human Mutation, 2003
Primary hepatocellular carcinoma (HCC) is one of the most common malignancies and has the fourth highest mortality rate worldwide. The major risk factors, including chronic infections with the hepatitis B or C virus, are exposure to dietary aflatoxin B1(AFB1), vinyl chloride, or alcohol consumption.
Frank, Staib, S Perwez, Hussain, Lorne J, Hofseth, Xin W, Wang, Curtis C, Harris   +4 more
openaire   +2 more sources

TP53-Associated Pediatric Malignancies [PDF]

Genes & Cancer, 2011
Although the majority of pediatric malignancies express wild-type p53, it is well established that germline TP53 mutations or functional inactivation of this pathway by other means contribute to childhood cancer. Epidemiology studies have revealed the existence of diverse inherited mutant TP53 alleles that display different levels of tumor suppressor ...
Emilia M, Pinto, Raul C, Ribeiro, Bonald C, Figueiredo, Gerard P, Zambetti   +3 more
openaire   +2 more sources

TP53 Mutations in Human Meningiomas [PDF]

The International Journal of Biological Markers, 2002
Overexpression of p53 has been reported to play a role in the development of neoplasms of the central nervous system. Meningiomas are generally benign intracranial tumors originating from the meninges. Overexpression of the p53 protein in meningiomas and an association with histological type and recurrence has been reported.
F M, Verheijen, M, Sprong, J M E, Kloosterman, G, Blaauw, J H H, Thijssen, M A, Blankenstein   +5 more
openaire   +2 more sources

Acute Mast Cell Leukemia Preceded by Malignant Mediastinal Germ Cell Tumor: A Case Report and Literature Review

Cancer Management and Research, 2022
Huafang Wang,1 Yuan Chen,2 Huijun Lin,3 Wanmao Ni,4 Qiaolei Zhang,5 Jianping Lan,1 Lai Jin1 1Cancer Center, Department of Hematology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang ...
Wang H, Chen Y, Lin H, Ni W, Zhang Q, Lan J, Jin L   +6 more
doaj  

Molecular and clinical aspects of HNSCC in the Republic of Moldova

Romanian Journal of Laboratory Medicine, 2023
Introduction: Complex molecular characterization and integrated approaches in the basic research of HNSCC provide new insights into the understanding and treatment of these tumors.
Stratan Valentina, Țuțuianu Valeri, Sîtnic Victor, Popa Cristina, Balan Veronica, Clipca Adrian, Sclifos Ina, Monastirscaia Anastasia, Trohin Victoria, Sprincean Mariana   +9 more
doaj   +1 more source

The relationship between TP53 and clinicopathological characteristics and their impact on the survival prognosis of patients with stage Ⅱ/Ⅲ colorectal cancer

结直肠肛门外科, 2023
[Objectives] To investigate TP53 and clinicopathological characteristics on the survival prognosis of patients with stage Ⅱ/Ⅲ colorectal cancer. [Methods] The clinical data of 57 patients with stage Ⅱ/Ⅲ colorectal cancer who were admitted to Wenzhou ...
Huang Lifeng, Huang Jian, Fan Yufang, Chen Yuemiao, Jiang Wei, Bao Yinghong, Cai Xiaoping   +6 more
doaj   +1 more source

Lung Squamous Cell Carcinoma with EML4-ALK Fusion and TP53 Co-mutation 
Treated with Ensartinib: A Case Report and Literature Review

Chinese Journal of Lung Cancer, 2023
Lung squamous cell carcinoma (LSCC) accounts for approximately 30% of non-small cell lung cancer (NSCLC) cases and is the second most common histological type of lung cancer.
Donglai LV, Chunwei XU, Chong WANG, Qiuju SANG   +3 more
doaj   +1 more source

Impact of TP53 mutations on the efficacy of CAR-T cell therapy in cancer

Exploration of Immunology
The efficacy of chimeric antigen receptor (CAR)-T therapy may not match initial expectations due to the influence of multiple circumstances, some of which cannot be predicted.
Regina Mirgayazova, Raniya Khadiullina, Maria Filimonova, Vitaly Chasov, Emil Bulatov   +4 more
doaj   +1 more source

TP53 rs1042522 polymorphism and early-onset breast cancer

Journal of Research in Medical Sciences, 2020
Background: Breast cancer is the leading cause of cancer deaths among women. Early-onset breast cancer is well recognized as it clinically differs from old-age diagnosed breast neoplasms.
Irmak Icen-Taskin, Sevgi Irtegun-Kandemir, Omer Munzuroglu   +2 more
doaj   +1 more source