Results 21 to 30 of about 1,694 (130)

Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK

Cancer Medicine, Volume 12, Issue 1, Page 488-499, January 2023., 2023
TPD52 forms a stable complex with AMPKα and negatively regulates AMPKα kinase activity. TPD52 modulates cell metabolism through regulating AMPK. Abstract Background The AMP‐activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases.
Yali Chen, Changmin Peng, Wei Tan, Jia Yu, Jacqueline Zayas, Yihan Peng, Zhenkun Lou, Huadong Pei, Liewei Wang   +8 more
wiley   +1 more source

Interacting partners of Golgi‐localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP‐Trap pull down

FEBS Letters, Volume 596, Issue 18, Page 2382-2399, September 2022., 2022
Identifying interactomes of membrane‐associated small G proteins is challenging. Here, we applied three proteomic approaches to identify the interactive neighbourhood of constitutively active Arl5b, a small G protein of the trans‐Golgi network (TGN). 50% of the hits were TGN/Golgi‐localised small G proteins, indicating an organised complex of small G ...
Fiona J. Houghton, Christian Makhoul, Ellie Hyun‐Jung Cho, Nicholas A. Williamson, Paul A. Gleeson   +4 more
wiley   +1 more source

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases [PDF]

, 2017
We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting ...
A Cepeda-Benito, A Durante, A Papadopoulos, A Parrales, A Pedram, AJ Leger, AL Farré, AT Franco, B Heinhuis, BH Im, C Giampietro, C Kiyohara, D Crosby, D Scharf, D Shiffman, DA Lewis, DD Haines, DG Hebels, DH Vandael, E Marcantoni, GW Zamponi, H Cao, H Wang, HA Powell, HL Hsieh, I Hers, IMS Shenker, K Nakai, KB Reddy, KH Chan, L Lanzetti, M Parra, M Roy-O’Reilly, M Vogler, ME Mangoni, MJ Puckelwartz, P Shende, P Wenzel, R Chaireti, R Chen, R Joehanes, R Li, RR Huxley, S Aryal, S Bingham, S Ramström, S Zeilinger, SA Peters, SM Baig, SM Smith, T Dolinay, T Gremmel, TG Nührenberg, TY Wang, Y Appelman, Y Wang, Y Yu, YA Senis, YF Melman, Z Wang   +59 more
core   +15 more sources

A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

Reproductive Medicine and Biology, Volume 21, Issue 1, January/December 2022., 2022
Abstract Purpose The receptive endometrium is critical for blastocyst implantation. In mice, after blastocysts enter the uterine cavities on day 4 of pregnancy (day 1 = vaginal plug), blastocyst attachment is completed within 24 h, accompanied by dynamic interactions between the uterine luminal epithelium and the blastocysts.
Shizu Aikawa, Yasushi Hirota, Yamato Fukui, Chihiro Ishizawa, Rei IIda, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga   +10 more
wiley   +1 more source

Cis and Trans Effects of Human Genomic Variants on Gene Expression [PDF]

, 2014
This work was funded by the Louis-Jeantet Foundation (http://www.jeantet.ch/), the European Research Council (Grant ID: 260927 http://erc.europa.eu/), the Swiss National Foundation (Grant ID: 130342 http://www.snf.ch), NCCR Frontiers In Genetics (http ...
A Boyd, AC Nica, AC Nica, AH Talukder, Alfonso Buil, AR Wood, AS Dimas, BE Stranger, BE Stranger, BU Schraml, C Wallace, Christopher David Brown, David M. Evans, DF Conrad, DJ Gaffney, DL Nicolae, DM Greenawalt, Donald F. Conrad, E Grundberg, E Klopocki, EE Schadt, Emmanouil T. Dermitzakis, George Davey Smith, GR Abecasis, H Huang, HJ Westra, J Ding, J Millstein, J Zhu, JD Storey, JE Powell, JK Pickrell, John P. Kemp, Julien Bryois, K Hildner, Karen M. Ho, LA Hindorff, M Gutierrez-Arcelus, M Scutari, Matthew Hurles, ND Miller, NL Barbosa-Morais, Panos Deloukas, RW Jones, SB Montgomery, SB Montgomery, SJ Loughran, Stephen B. Montgomery, Susan Ring, T Lappalainen, TR Insel, W Wang, Y Li, Y Li   +53 more
core   +5 more sources

The human RBPome: From genes and proteins to human disease [PDF]

, 2015
RNA binding proteins (RBPs) play a central role in mediating post transcriptional regulation of genes. However less is understood about them and their regulatory mechanisms.
Hashemikhabir, Seyedsasan, Janga, Sarath Chandra, Neelamraju, Yaseswini   +2 more
core   +1 more source

Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids [PDF]

, 2008
Background Chemotherapy (CT) resistance in ovarian cancer (OC) is broad and encompasses diverse unrelated drugs, suggesting more than one mechanism of resistance.
Tetu Bernard, Bachvarova Magdalena, L'Espérance Sylvain, Mes-Masson Anne-Marie, Bachvarov Dimcho   +4 more
core   +2 more sources

Tumor protein D54 defines a new class of intracellular transport vesicles [PDF]

, 2019
Transport of proteins and lipids from one membrane compartment to another is via intracellular vesicles. We investigated the function of tumor protein D54 (TPD54/TPD52L2) and found that TPD54 was involved in multiple membrane trafficking pathways ...
Balch, Biesemann, Boncompain, Bonifacino, Bucci, Byrne, Byrne, Byrne, Byrne, Cao, Cheeseman, Chen, Dasari, Dunlop, Edgar, Gabrielle Larocque, Geuze, Gillingham, Gordon, Gordon, Harris, Hein, Hirst, Hou, Huang, Jimenez, Junutula, Kamili, Kitt, Klöpper, Kozik, Kulak, Li, McCaughey, Messenger, Miller, Nicholas I. Clarke, Nicholas J. Carter, Nourse, Orci, Peden, Penelope J. La-Borde, Perry, Proux-Gillardeaux, Raposo, Robinson, Schindelin, Shahheydari, Shen, Shin, Stephen J. Royle, Takamori, Thomas, Thomas, Tisdale, Vigers, Wandinger-Ness, Wilson, Wong, Wood, Xu, Yoshimura, Zhang, Zhen   +63 more
core   +1 more source

DNA methylation during human adipogenesis and the impact of fructose [PDF]

, 2020
Background Increased adipogenesis and altered adipocyte function contribute to the development of obesity and associated comorbidities. Fructose modified adipocyte metabolism compared to glucose, but the regulatory mechanisms and consequences for obesity
Corrado Priami, Giulia Tini, Greg T. Nolen, Gregory Lefebvre, Jim Kaput, Marie-Pier Scott-Boyer, Patrick Descombes, Rosario Lombardo, Sylviane M('(e))tairon, Vijayalakshmi Varma   +9 more
core   +4 more sources