Results 11 to 20 of about 1,335 (104)

Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays [PDF]

BMC Genomics, 2008
Background Tumor-predominant splice isoforms were identified during comparative in silico sequence analysis of EST clones, suggesting that global aberrant alternative pre-mRNA splicing may be an epigenetic phenomenon in cancer. We used an exon expression
Hannah C Beird, Linda L Bachinski, Gilbert J Coté   +2 more
exaly   +4 more sources

Promyelocytic Leukemia (PML) Protein Plays Important Roles in Regulating Cell Adhesion, Morphology, Proliferation and Migration

PLoS ONE, 2013
PML protein plays important roles in regulating cellular homeostasis. It forms PML nuclear bodies (PML-NBs) that act like nuclear relay stations and participate in many cellular functions.
Mei Kuen Tang, Sing Wan Wong, Hsiang Fu Kung   +2 more
exaly   +3 more sources

Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats [PDF]

Journal of Animal Science and Biotechnology
Background Convergent evolution offers a unique lens through which to explore the molecular underpinnings of significant phenotypic transformations.
Zhanerke Akhatayeva, Yilong Shi, Kairat Dossybayev, Nurlan Malmakov, Hairong Cheng, Narantuya Baatar, Ji Yang, Menghua Li, Kejian Lin, Songsong Xu   +9 more
doaj   +2 more sources

Lentivirus-mediated TPD52L2 depletion inhibits the proliferation of liver cancer cells in vitro.

International journal of clinical and experimental medicine, 2015
Tumor protein D52-like 2, known as hD54 in previous studies (TPD52L2), is a member of TPD52 family which has been implicated in multiple human cancers. In recent reports, TPD52 proteins were indicated to be associated with several malignancies, but very little is known about the function of TPD52L2 in liver cancers.
Ze‐Ya Pan, Yun Yang, Hào Pān, Jin Zhang, Hui Liu, Yuan Yang, Gang Huang, Lei Yin, Jian Huang, Weiping Zhou   +9 more
openalex   +2 more sources

TPD52和TPD52L2在胃癌中异常表达的临床病理特征分析和相关基因共表达意义研究

Zhongguo shiyan zhenduanxue
目的 应用生物信息学的方法探讨肿瘤蛋白D52(tumor protein D52,TPD52)和肿瘤蛋白D52样2(tumor protein D52-like 2,TPD52L2)在胃癌中异常表达的临床病理特征，并分析相关基因共表达的意义。方法 基于癌症基因组图谱(The Cancer Genome AHas, TCGA)获取数据，利用R语言软件包比较TPD52和TPD52L2在胃癌组织和癌旁组织中的差异表达与临床病理特征的相关性，并探索与免疫细胞浸润水平的情况，Kaplan ...
高夏青, 杨春婷, 郭双铭, 韩静, 樊涛, 杨霄, 李海龙   +6 more
doaj   +1 more source

TPD52和TPD52L2在胃癌中异常表达的临床病理特征分析和相关基因共表达意义研究 附视频

Zhongguo shiyan zhenduanxue
目的 应用生物信息学的方法探讨肿瘤蛋白D52(tumor protein D52,TPD52)和肿瘤蛋白D52样2(tumor protein D52-like 2,TPD52L2)在胃癌中异常表达的临床病理特征，并分析相关基因共表达的意义。方法 基于癌症基因组图谱(The Cancer Genome AHas, TCGA)获取数据，利用R语言软件包比较TPD52和TPD52L2在胃癌组织和癌旁组织中的差异表达与临床病理特征的相关性，并探索与免疫细胞浸润水平的情况，Kaplan ...
doaj   +3 more sources

Identification of Key MicroRNAs and Genes between Colorectal Adenoma and Colorectal Cancer via Deep Learning on GEO Databases and Bioinformatics.

Contrast Media Mol Imaging, 2023
Background. Deep learning techniques are gaining momentum in medical research. Colorectal adenoma (CRA) is a precancerous lesion that may develop into colorectal cancer (CRC) and its etiology and pathogenesis are unclear. This study aims to identify transcriptome differences between CRA and CRC via deep learning on Gene Expression Omnibus (GEO ...
Zhang X, Jin M, Liu F, Qu H, Chen C.
europepmc   +2 more sources

GRB2 Promotes Malignant Behaviors of Breast Cancer by Modulating the Global Expression and Alternative Splicing Profiles in SK-BR-3 Cells Through Binding mRNA. [PDF]

Cancer Med
GRB2 as a flexible protein and an RBP that is involved in post‐transcriptional regulation in eukaryotes, influencing all stages of mRNA synthesis, modification, splicing, and stabilization. ABSTRACT Purpose The flexible protein GRB2 interacts with HER1–4 on the cell surface and regulates the development of tumor cells; meanwhile, it is also an RBP that
Liu W, Huang Y, Qiao L, Chong L, Xia L, Abudurehaman A, Li H.   +6 more
europepmc   +2 more sources

Mapping the intracellular HMGB1 interactome and alterations induced by Toll-like receptor 4 activation [PDF]

Journal of Biological Chemistry
Rebecka Heinbäck, Alexander Espinosa, Helena Erlandsson Harris   +2 more
exaly   +2 more sources

Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia

Journal of Extracellular Vesicles, Volume 12, Issue 12, December 2023., 2023
Abstract Periodontitis is a chronic inflammatory disease caused by periodontal pathogens in subgingival plaque and is associated with systemic inflammatory diseases. Extracellular vesicles (EVs) released from host cells and pathogens carry a variety of biological molecules and are of interest for their role in disease progression and as diagnostic ...
Younggap Lim, Hyun Young Kim, Dohyun Han, Bong‐Kyu Choi   +3 more
wiley   +1 more source