Results 11 to 20 of about 1,694 (130)

Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays

BMC Genomics, 2008
Background Tumor-predominant splice isoforms were identified during comparative in silico sequence analysis of EST clones, suggesting that global aberrant alternative pre-mRNA splicing may be an epigenetic phenomenon in cancer. We used an exon expression
Hannah C Cheung, Gilbert J Cote, Ralf Krahe   +2 more
exaly   +3 more sources

Promyelocytic Leukemia (PML) Protein Plays Important Roles in Regulating Cell Adhesion, Morphology, Proliferation and Migration

PLoS ONE, 2013
PML protein plays important roles in regulating cellular homeostasis. It forms PML nuclear bodies (PML-NBs) that act like nuclear relay stations and participate in many cellular functions.
Mei Kuen Tang, Sing-Wan Wong, Kenneth Ka Ho Lee   +2 more
exaly   +2 more sources

Identification of Key MicroRNAs and Genes between Colorectal Adenoma and Colorectal Cancer via Deep Learning on GEO Databases and Bioinformatics.

Contrast Media Mol Imaging, 2023
Background. Deep learning techniques are gaining momentum in medical research. Colorectal adenoma (CRA) is a precancerous lesion that may develop into colorectal cancer (CRC) and its etiology and pathogenesis are unclear. This study aims to identify transcriptome differences between CRA and CRC via deep learning on Gene Expression Omnibus (GEO ...
Zhang X, Jin M, Liu F, Qu H, Chen C.
europepmc   +2 more sources

GRB2 Promotes Malignant Behaviors of Breast Cancer by Modulating the Global Expression and Alternative Splicing Profiles in SK-BR-3 Cells Through Binding mRNA. [PDF]

Cancer Med
GRB2 as a flexible protein and an RBP that is involved in post‐transcriptional regulation in eukaryotes, influencing all stages of mRNA synthesis, modification, splicing, and stabilization. ABSTRACT Purpose The flexible protein GRB2 interacts with HER1–4 on the cell surface and regulates the development of tumor cells; meanwhile, it is also an RBP that
Liu W, Huang Y, Qiao L, Chong L, Xia L, Abudurehaman A, Li H.   +6 more
europepmc   +2 more sources

Mapping the intracellular HMGB1 interactome and alterations induced by Toll-like receptor 4 activation [PDF]

Journal of Biological Chemistry
Cecilia Aulin
exaly   +2 more sources

Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia

Journal of Extracellular Vesicles, Volume 12, Issue 12, December 2023., 2023
Abstract Periodontitis is a chronic inflammatory disease caused by periodontal pathogens in subgingival plaque and is associated with systemic inflammatory diseases. Extracellular vesicles (EVs) released from host cells and pathogens carry a variety of biological molecules and are of interest for their role in disease progression and as diagnostic ...
Younggap Lim, Hyun Young Kim, Dohyun Han, Bong‐Kyu Choi   +3 more
wiley   +1 more source

Identification of diagnostic markers of pancreatic ductal adenocarcinoma using transcriptomic tumour and blood sample data

Clinical and Translational Discovery, Volume 3, Issue 5, October 2023., 2023
In this study, we pool publicly available gene expression data from clinical samples (tissue biopsies and blood samples) and derive and validate a signature of consistently deregulated genes across pancreatic ductal adenocarcinoma (PDAC) samples.
Aristeidis Sionakidis, Panagiotis Nikolaos Lalagkas, Andigoni Malousi, Ioannis S. Vizirianakis   +3 more
wiley   +1 more source

TPD52L2 impacts proliferation, invasiveness and apoptosis of glioblastoma cells via modulation of wnt/β-catenin/snail signaling [PDF]

Carcinogenesis, 2017
Intratumoral heterogeneity greatly hinders efficiency of target therapy in glioblastoma (GBM). To decipher the underlying mechanisms of heterogeneity, patient-derived adult GBM cells were separately isolated from margins of T1 gadolinium enhancing tumor lesions (PNCs) and T1 gadolinium enhancing core lesions (ECs). Single clone culture was conducted in
Zhou, Qiang, Li, Jun-Jie, Wang, Hai, Li, Hong, Lei, Bing-Xi, Chen, Lei, Xiang, Wei, Liu, Ya-Wei, Annie, Huang, Qi, Song-Tao, Lu, Yun-Tao   +10 more
openaire   +2 more sources

Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis

Brain Pathology, Volume 33, Issue 5, September 2023., 2023
A combined stereological and proteomic analysis revealed amygdala volume reduction linked to synaptic dysfunction in Alzheimer''s disease samples. The pathological markers gradient suggested the relevance of connections in the distribution of the pathology among different brain regions.
Melania Gonzalez‐Rodriguez, Sandra Villar‐Conde, Veronica Astillero‐Lopez, Patricia Villanueva‐Anguita, Isabel Ubeda‐Banon, Alicia Flores‐Cuadrado, Alino Martinez‐Marcos, Daniel Saiz‐Sanchez   +7 more
wiley   +1 more source

Clathrin light chain A‐enriched small extracellular vesicles remodel microvascular niche to induce hepatocellular carcinoma metastasis

Journal of Extracellular Vesicles, Volume 12, Issue 8, August 2023., 2023
Abstract Small extracellular vesicles (sEVs) play a key role in exchanging cargoes between cells in tumour microenvironment. This study aimed to elucidate the functions and mechanisms of hepatocellular carcinoma (HCC) derived sEV‐clathrin light chain A (CLTA) in remodelling microvascular niche.
Yi Xu, Yue Yao, Liang Yu, Xiaoxin Zhang, Xiaowen Mao, Sze Keong Tey, Samuel Wan Ki Wong, Cherlie Lot Sum Yeung, Tung Him Ng, Melody YM Wong, Chi‐Ming Che, Terence Kin Wah Lee, Yi Gao, Yunfu Cui, Judy Wai Ping Yam   +14 more
wiley   +1 more source