Results 1 to 10 of about 1,393 (84)

A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review [PDF]

Diagnostic Pathology, 2023
Background Inflammatory myofibroblastic tumor (IMT) is a distinctive tumor composed of spindle cells accompanied by mixed inflammatory cells, and immunohistochemical positivity for ALK (anaplastic lymphoma kinase protein) can be detected in half of IMTs.
Yaqi Duan, Guoping Wang
exaly   +3 more sources

TPD52L2 Is a Prognostic Biomarker and Correlated With Immune Infiltration in Lung Adenocarcinoma [PDF]

Frontiers in Pharmacology, 2021
Tumor protein D52-like 2 (TPD52L2) belongs to the members of the TPD52 family. TPD52L2 was reported to regulate proliferation and apoptosis in cancer cells. However, its role in lung adenocarcinoma (LUAD) was uncertain.
Zengli Zhang
exaly   +4 more sources

Overexpression of TPD52L2 in HNSCC: prognostic significance and correlation with immune infiltrates [PDF]

BMC Oral Health
Background Evidence has been presented that the tumor protein D52 (TPD52) family plays a critical role in tumor development and progression. As a member of the TPD52 family, the changes in TPD52L2 gene status are instrumental in kinds of cancer ...
Hanwei Peng
exaly   +3 more sources

Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats [PDF]

Journal of Animal Science and Biotechnology
Background Convergent evolution offers a unique lens through which to explore the molecular underpinnings of significant phenotypic transformations.
Kairat Dossybayev, Zhanerke Akhatayeva, Hairong Cheng   +2 more
exaly   +3 more sources

TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma [PDF]

Frontiers in Oncology, 2023
BackgroundTumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.MethodsMultiple omics ...
Hongbo Wang, Zhendong Liu, Yuelin Du, Xingbo Cheng, Shanjun Gao, Yanzheng Gao, Panfeng Shang   +6 more
doaj   +2 more sources

Mesenchymal stromal cells secretory pattern contributes to oncoinflammatory bone marrow microenvironment in polycythemia vera [PDF]

Hematology, Transfusion and Cell Therapy
Introduction: Polycythemia vera is a myeloproliferative neoplasm marked by an increased proliferation of erythroid mature and precursors cells in bone marrow and peripheral blood. The pathophysiology is linked to the presence of the JAK2 driver mutation,
Juçara Gastaldi Cominal, Maira da Costa Cacemiro, Giovana Michelassi Berbel, Rifkath Marie Laurance Rahimy, Gisele Vieira Rocha, Dalila Lucíola Zanette, Maria Carolina Oliveira, Lorena Lobo de Figueiredo-Pontes, Kelen Cristina Ribeiro Malmegrim, Fabíola Attié de Castro   +9 more
doaj   +2 more sources

2-Hydroxyisobutyrylation and Phosphorylation Crosstalk Guides Metastasis Prediction and Immunotherapy in Esophageal Squamous Cell Carcinoma. [PDF]

MedComm (2020)
This study deciphers the functional crosstalk between 2‐hydroxyisobutyrylation (Khib) and phosphorylation in driving esophageal squamous cell carcinoma (ESCC) metastasis. Through multi‐omics and machine learning, we developed a plasma protein signature for noninvasive detection of lymph node metastasis.
Li J, Li S, Yu X, Mu Q, Luo M, Wang Y, Liu Z, Gu C, Chen J, He W, Yang T, He Y, Pei X, Lin M, Li Z, Liu J, Zhao B, Zhang F, Liu J, Li B, Xu W.   +20 more
europepmc   +2 more sources

Identification of Key MicroRNAs and Genes between Colorectal Adenoma and Colorectal Cancer via Deep Learning on GEO Databases and Bioinformatics.

Contrast Media Mol Imaging, 2023
Background. Deep learning techniques are gaining momentum in medical research. Colorectal adenoma (CRA) is a precancerous lesion that may develop into colorectal cancer (CRC) and its etiology and pathogenesis are unclear. This study aims to identify transcriptome differences between CRA and CRC via deep learning on Gene Expression Omnibus (GEO ...
Zhang X, Jin M, Liu F, Qu H, Chen C.
europepmc   +2 more sources

Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays

BMC Genomics, 2008
Background Tumor-predominant splice isoforms were identified during comparative in silico sequence analysis of EST clones, suggesting that global aberrant alternative pre-mRNA splicing may be an epigenetic phenomenon in cancer. We used an exon expression
Gilbert Cote, Hannah Beird, Ralf Krahe
exaly   +3 more sources

Promyelocytic Leukemia (PML) Protein Plays Important Roles in Regulating Cell Adhesion, Morphology, Proliferation and Migration

PLoS ONE, 2013
PML protein plays important roles in regulating cellular homeostasis. It forms PML nuclear bodies (PML-NBs) that act like nuclear relay stations and participate in many cellular functions.
Mei Kuen Tang, Kenneth Ka Ho Lee, Hsiang Fu Kung   +2 more
exaly   +2 more sources