TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma [PDF]
Frontiers in Oncology, 2023 BackgroundTumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.MethodsMultiple omics ...
Hongbo Wang, Yuelin Du, Shanjun Gao
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TPD52L2 Is a Prognostic Biomarker and Correlated With Immune Infiltration in Lung Adenocarcinoma [PDF]
Frontiers in Pharmacology, 2021 Tumor protein D52-like 2 (TPD52L2) belongs to the members of the TPD52 family. TPD52L2 was reported to regulate proliferation and apoptosis in cancer cells. However, its role in lung adenocarcinoma (LUAD) was uncertain.
Anyuan Zhong +2 more
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A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review [PDF]
Diagnostic Pathology, 2023 Background Inflammatory myofibroblastic tumor (IMT) is a distinctive tumor composed of spindle cells accompanied by mixed inflammatory cells, and immunohistochemical positivity for ALK (anaplastic lymphoma kinase protein) can be detected in half of IMTs.
Liu Xuguang, Zhu Pengcheng
exaly +7 more sources
Overexpression of TPD52L2 in HNSCC: prognostic significance and correlation with immune infiltrates [PDF]
BMC Oral HealthBackground Evidence has been presented that the tumor protein D52 (TPD52) family plays a critical role in tumor development and progression. As a member of the TPD52 family, the changes in TPD52L2 gene status are instrumental in kinds of cancer ...
Hanwei Peng, Lu Min
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Investigation of Transcript Variant 6 of TPD52L2 as a Prognostic and Predictive Biomarker in Basal-Like MDA-MB-231 and MDA-MB-453 Cell Lines for Breast Cancer. [PDF]
Oxid Med Cell Longev, 2022 Background. Basal‐like breast cancer (BLBC) exhibits worse pathological features than other breast cancer subtypes, and patients diagnosed with BLBC have short disease‐free and overall survival times. Thus, the identification of novel biomarkers and therapeutic targets for BLBC is of upmost importance.
Zhang X, O'Brien D, Zhang X.
europepmc +5 more sources
The Antitumor Effect of TPD52L2 Silencing on Oxaliplatin-Resistant Gastric Carcinoma Is Related to Endoplasmic Reticulum Stress In Vitro. [PDF]
Evid Based Complement Alternat Med, 2022 Tumor protein D52-like 2 or simply TPD52L2 belongs to the TPD52 family which has been implicated in a variety of human carcinomas. However, the TPD52L2 function in the gastric carcinoma oxaliplatin (OXA) resistance remains elusive. The main objective of this study is to evaluate the TPD52L2 effect in OXA-resistant gastric carcinoma cells in vitro ...
Zhang Y +8 more
europepmc +5 more sources
Dual oncogenic roles of TPD52 and TPD52L2 in gastric cancer progression via PI3K/AKT activation and immunosuppressive microenvironment remodeling. [PDF]
Brief Funct GenomicsAbstract Aim TPD52 (tumor protein D52) and TPD52L2 (tumor protein D52-like 2), members of the TPD52 gene family, have been implicated in multiple malignancies. However, their roles in gastric cancer (GC) remain elusive. Herein, we integrated multiomics analyses and experimental validation to elucidate
Li H +9 more
europepmc +5 more sources
Oncology Reports, 2017 MicroRNAs (miRNAs) play important roles in the regulation of various tumor biological processes including proliferation and apoptosis. miR-217 has been implicated in many types of cancer, whereas its expression and potential biological function in human pancreatic adenocarcinoma (HPAC) remain unclear.
Qiuyang Chen, Xinchun Liu, Jishu Wei
exaly +6 more sources
Mesenchymal stromal cells secretory pattern contributes to oncoinflammatory bone marrow microenvironment in polycythemia vera [PDF]
Hematology, Transfusion and Cell TherapyIntroduction: Polycythemia vera is a myeloproliferative neoplasm marked by an increased proliferation of erythroid mature and precursors cells in bone marrow and peripheral blood. The pathophysiology is linked to the presence of the JAK2 driver mutation,
Juçara Gastaldi Cominal +9 more
doaj +2 more sources
TPD52L2 impacts proliferation, invasiveness and apoptosis of glioblastoma cells via modulation of wnt/β-catenin/snail signaling [PDF]
Carcinogenesis, 2017 Intratumoral heterogeneity greatly hinders efficiency of target therapy in glioblastoma (GBM). To decipher the underlying mechanisms of heterogeneity, patient-derived adult GBM cells were separately isolated from margins of T1 gadolinium enhancing tumor lesions (PNCs) and T1 gadolinium enhancing core lesions (ECs). Single clone culture was conducted in
Zhou Qiang +10 more
openalex +3 more sources