Results 41 to 50 of about 1,694 (130)

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation [PDF]

, 2021
Current strategies to target RNA splicing mutant myeloid cancers proposes targeting the remaining splicing apparatus. This approach has only been modestly sensitizing and is also toxic to non-mutant-bearing wild-type cells.
Chalk, Alistair M., Nikolic, Iva, Simpson, Kaylene J., Smeets, Monique F., Walkley, Carl R., Xu, Jane Jialu   +5 more
core   +1 more source

New insights into the mechanisms of childhood food allergies

Pediatric Allergy and Immunology, Volume 36, Issue 4, April 2025.
Abstract IgE‐mediated food allergies are common and can be life‐threatening, especially for children. With increasingly rapid advances in immunological technologies, including the ability to profile highly complex immune features from small sample volumes, our understanding of the immune mechanisms that underpin the development of food allergies ...
Liam Gubbels, Richard Saffery, Melanie R. Neeland   +2 more
wiley   +1 more source

Time‐Lapse Acquisition of Both Freely Secreted Proteome and Exosome Encapsulated Proteome in Live Organoids’ Microenvironment

Advanced Science, Volume 12, Issue 2, January 13, 2025.
Proteomic communications in neighboring microenvironments during early organ development is a dynamic process continuously reshaping hESCs developmental fate. Such dynamic proteomic alteration consists of freely secreted proteome and exosome‐encapsulated proteome.
Haoni Yan, Aynur Abdulla, Aiting Wang, Shuyu Ding, Manlin Zhang, Yizhi Zhang, Tsz Yui Zhuang, Leqi Wu, Yan Wang, Rongrong Ren, Lai Jiang, Xianting Ding   +11 more
wiley   +1 more source

The selenoenzyme type I iodothyronine deiodinase: a new tumor suppressor in ovarian cancer

Molecular Oncology, Volume 18, Issue 9, Page 2298-2313, September 2024.
The selenoenzyme deiodinase type 1 (DIO1) has anti‐tumor actions in high‐grade serous ovarian cancer. Reduced levels of DIO1 in HGSOC cells and human tissues facilitate proliferation and may promote tumorigenesis in this aggressive disease. The selenoenzyme type I iodothyronine deiodinase (DIO1) catalyzes removal of iodine atoms from thyroid hormones ...
Adi Alfandari, Dotan Moskovich, Avivit Weisz, Aviva Katzav, Debora Kidron, Mario Beiner, Dana Josephy, Aula Asali, Yael Hants, Yael Yagur, Omer Weitzner, Martin Ellis, Gilad Itchaki, Osnat Ashur‐Fabian   +13 more
wiley   +1 more source

Circadian and light-driven regulation of rod dark adaptation [PDF]

, 2015
Continuous visual perception and the dark adaptation of vertebrate photoreceptors after bright light exposure require recycling of their visual chromophore through a series of reactions in the retinal pigmented epithelium (RPE visual cycle). Light-driven
Corbo, Joseph C, Kefalov, Vladimir J, Shen, Susan Q, Xue, Yunlu   +3 more
core   +2 more sources

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source

HB‐EGF‐loaded nanovesicles enhance trophectodermal spheroid attachment and invasion

PROTEOMICS, Volume 24, Issue 11, June 2024.
Abstract The ability of trophectodermal cells (outer layer of the embryo) to attach to the endometrial cells and subsequently invade the underlying matrix are critical stages of embryo implantation during successful pregnancy establishment. Extracellular vesicles (EVs) have been implicated in embryo‐maternal crosstalk, capable of reprogramming ...
Qi Hui Poh, Alin Rai, Jonathon Cross, David W. Greening   +3 more
wiley   +1 more source

Pathway discovery using transcriptomic profiles in adult-onset severe asthma [PDF]

, 2018
Rationale Adult-onset severe asthma is characterized by highly symptomatic disease despite high intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease needed for the development of targeted treatments.
Adcock, IM, Auffray, C, Bansal, A, Baribaud, F, Bates, S, Bel, EH, Brinkman, P, Chung, KF, Corfield, J, De Meulder, B, Djukanovic, R, Fleming, L, Fowler, SJ, Guo, Y, Hekking, PP, Howarth, P, Lefaudeux, D, Loza, MJ, Lutter, I, Meiser, A, Pandis, Y, Pavlidis, S, Shaw, DE, Sousa, A, Sterk, PJ, Sun, K, U-BIOPRED Study Group, Wagener, A   +27 more
core   +1 more source

Analysis of 206 whole‐genome resequencing reveals selection signatures associated with breed‐specific traits in Hu sheep

Evolutionary Applications, Volume 17, Issue 6, June 2024.
Abstract As an invaluable Chinese sheep germplasm resource, Hu sheep are renowned for their high fertility and beautiful wavy lambskins. Their distinctive characteristics have evolved over time through a combination of artificial and natural selection. Identifying selection signatures in Hu sheep can provide a straightforward insight into the mechanism
Fuping Zhao, Rui Xie, Lingzhao Fang, Ruidong Xiang, Zehu Yuan, Yang Liu, Lixian Wang   +6 more
wiley   +1 more source

Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc

Journal of Oncology, Volume 2024, Issue 1, 2024.
Zinc dyshomeostasis is manifested in breast and prostate cancer cells. This study attempted to uncover the molecular details prodded by the change of extracellular zinc by employing a panel of normal and cancerous breast and prostate cell lines coupled with the top‐down proteomics with two‐dimensional gel electrophoresis followed by liquid ...
Shital K. Barman, Monokesh K. Sen, David A. Mahns, Ming J. Wu, Chandra S. Malladi, Yuan Seng Wu   +5 more
wiley   +1 more source