Using interspecies biological networks to guide drug therapy [PDF]
, 2017 The use of drug combinations (DCs) in cancer therapy can prevent the development of drug resistance and decrease the severity and number of side effects. Synthetic lethality (SL), a genetic interaction wherein two nonessential genes cause cell death when
Jacunski, Alexandra
core +2 more sources
Multiple Tests of Association with Biological Annotation Metadata [PDF]
, 2006 We propose a general and formal statistical framework for the multiple tests of associations between known fixed features of a genome and unknown parameters of the distribution of variable features of this genome in a population of interest.
Dudoit, Sandrine +2 more
core +1 more source
Lentivirus-mediated TPD52L2 depletion inhibits the proliferation of liver cancer cells in vitro.
International journal of clinical and experimental medicine, 2015 Tumor protein D52-like 2, known as hD54 in previous studies (TPD52L2), is a member of TPD52 family which has been implicated in multiple human cancers. In recent reports, TPD52 proteins were indicated to be associated with several malignancies, but very little is known about the function of TPD52L2 in liver cancers.
Ze-Ya, Pan +9 more
openaire +1 more source
Defining the molecular pathology of pancreatic body and tail adenocarcinom [PDF]
, 2018 Background: Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease, with very little improvement in survival over the past 50 years. Recent large-scale genomic studies have improved understanding of the genomic and transcriptomic landscape of
Australian Pancreatic Cancer Genome Initiative, +7 more
core +1 more source
Role of TPD52L2 in cell migration and triple-negative breast cancer progression
, 2023 The TPD52 family comprises four related proteins: TPD52, TPD53, TPD54, and TPD55 (also known as respectively as TPD52L1, TPD52L2, and TPD52L3) (1). They share similar features, such as a molecular weight of 22.2 kDa with 206 amino acids, and their C-terminal regions show high conservation.
openaire +1 more source
Constructing gene expression based prognostic models to predict recurrence and lymph node metastasis in colon cancer [PDF]
, 2008 The main goal of this study is to identify molecular signatures to predict lymph node metastases and recurrence in colon cancer patients. Recent advances in microarray technology facilitated building of accurate molecular classifiers, and in depth ...
Mettu, Ramakanth Reddy
core +1 more source
Label-free tissue proteomics can classify oral squamous cell carcinoma from healthy tissue in a stage-specific manner [PDF]
, 2018 Objectives: No prognostic or predictive biomarkers for oral squamous cell carcinoma (OSCC) exist. We aimed to discover novel proteins, altered in OSCC, to be further investigated as potential biomarkers, and to improve understanding about pathways ...
Dickinson, Amy +7 more
core +1 more source
TPD52 (tumor protein D52) [PDF]
, 2011 Review on TPD52 (tumor protein D52), with data on DNA, on the protein encoded, and where the gene is ...
Byrne, J, Della-Franca, A
core +1 more source
Search for peripheral biomarkers in patients affected by acutely psychotic bipolar disorder: a proteomic approach [PDF]
, 2014 Data on neurobiological mechanisms underlying mood disorders are elusive; the aetiology of such states is multifactorial, including genetic predisposition and environmental factors. Diagnosis is currently being made only on an interview-based methodology.
VENTRONI, TIZIANA
core
Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes [PDF]
, 2018 The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are ...
Athanasiou, Ioannis +13 more
core +1 more source