Results 31 to 40 of about 1,420 (101)

Proteomic Analysis of Extracellular Vesicles Identifies CDCP1 as Critical Metastasis‐Related Glycoprotein in Lung Cancer

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
Abstract Lung cancer is the most prevalent malignancy worldwide, with the majority of fatalities attributed to metastasis. Recent studies have demonstrated the pivotal role of extracellular vesicles (EVs) and glycoproteins in tumor progression. In this study, we compared the glycoproteome of EVs from 95C (low metastatic) and 95D (high metastatic) lung ...
Lu Zhang   +7 more
wiley   +1 more source

New insights into the mechanisms of childhood food allergies

open access: yesPediatric Allergy and Immunology, Volume 36, Issue 4, April 2025.
Abstract IgE‐mediated food allergies are common and can be life‐threatening, especially for children. With increasingly rapid advances in immunological technologies, including the ability to profile highly complex immune features from small sample volumes, our understanding of the immune mechanisms that underpin the development of food allergies ...
Liam Gubbels   +2 more
wiley   +1 more source

Time‐Lapse Acquisition of Both Freely Secreted Proteome and Exosome Encapsulated Proteome in Live Organoids’ Microenvironment

open access: yesAdvanced Science, Volume 12, Issue 2, January 13, 2025.
Proteomic communications in neighboring microenvironments during early organ development is a dynamic process continuously reshaping hESCs developmental fate. Such dynamic proteomic alteration consists of freely secreted proteome and exosome‐encapsulated proteome.
Haoni Yan   +11 more
wiley   +1 more source

The selenoenzyme type I iodothyronine deiodinase: a new tumor suppressor in ovarian cancer

open access: yesMolecular Oncology, Volume 18, Issue 9, Page 2298-2313, September 2024.
The selenoenzyme deiodinase type 1 (DIO1) has anti‐tumor actions in high‐grade serous ovarian cancer. Reduced levels of DIO1 in HGSOC cells and human tissues facilitate proliferation and may promote tumorigenesis in this aggressive disease. The selenoenzyme type I iodothyronine deiodinase (DIO1) catalyzes removal of iodine atoms from thyroid hormones ...
Adi Alfandari   +13 more
wiley   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

open access: yesJournal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan   +16 more
wiley   +1 more source

HB‐EGF‐loaded nanovesicles enhance trophectodermal spheroid attachment and invasion

open access: yesPROTEOMICS, Volume 24, Issue 11, June 2024.
Abstract The ability of trophectodermal cells (outer layer of the embryo) to attach to the endometrial cells and subsequently invade the underlying matrix are critical stages of embryo implantation during successful pregnancy establishment. Extracellular vesicles (EVs) have been implicated in embryo‐maternal crosstalk, capable of reprogramming ...
Qi Hui Poh   +3 more
wiley   +1 more source

Analysis of 206 whole‐genome resequencing reveals selection signatures associated with breed‐specific traits in Hu sheep

open access: yesEvolutionary Applications, Volume 17, Issue 6, June 2024.
Abstract As an invaluable Chinese sheep germplasm resource, Hu sheep are renowned for their high fertility and beautiful wavy lambskins. Their distinctive characteristics have evolved over time through a combination of artificial and natural selection. Identifying selection signatures in Hu sheep can provide a straightforward insight into the mechanism
Fuping Zhao   +6 more
wiley   +1 more source

Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc

open access: yesJournal of Oncology, Volume 2024, Issue 1, 2024.
Zinc dyshomeostasis is manifested in breast and prostate cancer cells. This study attempted to uncover the molecular details prodded by the change of extracellular zinc by employing a panel of normal and cancerous breast and prostate cell lines coupled with the top‐down proteomics with two‐dimensional gel electrophoresis followed by liquid ...
Shital K. Barman   +5 more
wiley   +1 more source

Striking similarities between publications from China describing single gene knockdown experiments in human cancer cell lines

open access: yes, 2017
International audienceComparing 5 publications from China that described knockdowns of the human TPD52L2 gene in human cancer cell lines identified unexpected similarities between these publications, flaws in experimental design, and mis-matches between ...
Byrne, Jennifer A., Labbe, Cyril
core   +1 more source

Abstract 1990: Exploratory analysis of the usefulness of the top-scoring pairs (TSP) of genes for prediction of prostate cancer progression

open access: yes, 2010
Predicting prostate cancer progression after radical prostatectomy is most challenging. Gene expression profiling is widely used to identify genes associated with cancer progression.
Hongya Zhao   +2 more
core   +1 more source

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