Results 81 to 90 of about 69,255 (308)
, 2022 Wissenschaftlich betrachtet, liefert die TPM-Konzeption in den Einzelelementen keine wesentlichen neuen Lösungsansätze: - Organisationslehre, - Qualitätsmanagement, - Arbeitssystemgestaltung, (Gruppenarbeit) - Arbeitspsychologie, - Personalaus- und ...
Jacobi, H.-F.
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Advanced Science, EarlyView.This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He +10 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
Lean TPM: a blueprint for change.
, 2004 Key Features Unites the concepts of world-class manufacturing, Lean and TPM. Shows how to accelerate the benefits gained from continuous improvement activities. Includes an integrated route map for Lean TPM, including benchmark data. Description
Rich, Nicholas Leo, McCarthy, Dennis
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Mit TPM Veränderungen beherrschen
, 2014 Die Säulen von TPM, Rahmenbedingungen für die TPM-Einführung, Personalqualifikation, Praxis- und ...
Heller, Thomas
core +1 more source
Advanced Science, EarlyView.ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang +8 more
wiley +1 more source
Total Productive Maintenance and predictive maintenance in Industry 4.0
, 2023 openLa Quarta Rivoluzione Industriale ha portato ad uno sviluppo dell’industria verso l’era della produzione avanzata, nota come Industria 4.0, e ad una crescente integrazione di tecnologie digitali e processi automatizzati nei contesti produttivi.
BUTTURINI, MARCO
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Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source
Advanced Science, EarlyView.Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou +10 more
wiley +1 more source