Results 161 to 170 of about 8,275 (209)

Mechanisms of osteopontin-stabilized amorphous calcium phosphate calcification in benign and pre-malignant breast disease. [PDF]

Sci Rep
Sivaguru M, Schrup SE, Fouke KW, Sherman ME, Samuel AZ, Maimone S, Bhargava R, Fouke BW.   +7 more
europepmc   +1 more source

The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology. [PDF]

J Clin Invest
Kager L, Boztug K.
europepmc   +1 more source

Follicle fiasco - Unraveling the cause of sudden hair loss!

Indian J Pharmacol
Mehta S, Bhatia K, Namdeo C, Bhatia L.
europepmc   +1 more source

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Mechanism of allopurinol induced TPMT inhibition

Biochemical Pharmacology, 2013
Up to 1/5 of patients with wildtype thiopurine-S-methyltransferase (TPMT) activity prescribed azathioprine (AZA) or mercaptopurine (MP) demonstrate a skewed drug metabolism in which MP is preferentially methylated to yield methylmercaptopurine (MeMP).
Blaker, P. A., Arenas-Hernandez, M., Smith, M. A., Shobowale-Bakre, E. A., Fairbanks, L., Irving, P. M., Sanderson, Jeremy, Marinaki, A. M.   +7 more
exaly   +4 more sources

Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells

Pharmacogenetics, 1999
Inheritance of the TPMT*2, TPMT*3A and TPMT*3C mutant alleles is associated with deficiency of thiopurine S-methyltransferase (TPMT) activity in humans. However, unlike TPMT*2 and TPMT*3A, the catalytically active protein coded by TPMT*3C does not undergo enhanced proteolysis when heterologously expressed in yeast, making it unclear why this common ...
H L, Tai, M Y, Fessing, E J, Bonten, Y, Yanishevsky, A, d'Azzo, E Y, Krynetski, W E, Evans   +6 more
openaire   +2 more sources

Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23

Pharmacogenetics and Genomics, 2007
Thiopurine methyltransferase (TPMT) is a polymorphic enzyme involved in the metabolism of thiopurine drugs. Owing to polymorphisms in the TPMT gene (TPMT*2-*22), the enzyme activity varies interindividually. Patients with reduced TPMT activity may develop adverse reactions when treated with standard doses of thiopurines.
Malin, Lindqvist, Karin, Skoglund, Anna, Karlgren, Peter, Söderkvist, Curt, Peterson, Irene, Kidhall, Sven, Almer   +6 more
openaire   +2 more sources

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.

Proceedings of the National Academy of Sciences of the United States of America, 1997
TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and thioguanine. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT deficiency are at high risk of potentially fatal hematopoietic toxicity.
H L, Tai, E Y, Krynetski, E G, Schuetz, Y, Yanishevski, W E, Evans   +4 more
openaire   +2 more sources