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Therapeutic Drug Monitoring and Pharmacogenomics of Thiopurines in Inflammatory Bowel Disease: International Guidelines Revisited. [PDF]
Ther Drug MonitBayoumy AB, Derijks LJJ, de Boer NKH.
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Azathioprine-Induced Eosinophilia and Acute Cholestatic Hepatitis in Lupus Nephritis: An Early Hypersensitivity-Mediated Presentation of Thiopurine-Associated Drug-Induced Liver Injury. [PDF]
CureusAli S +5 more
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Pharmacogenetics and Genomics, 2007 Thiopurine methyltransferase (TPMT) is a polymorphic enzyme involved in the metabolism of thiopurine drugs. Owing to polymorphisms in the TPMT gene (TPMT*2-*22), the enzyme activity varies interindividually. Patients with reduced TPMT activity may develop adverse reactions when treated with standard doses of thiopurines.
Malin, Lindqvist +6 more
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Functional Analysis of the Role of theTPMTGene Promoter VNTR Polymorphism inTPMTGene Transcription
Pharmacogenomics, 2010 Thiopurine S-methyltransferase (TPMT) activity is polymorphic, and a trimodal distribution has been demonstrated in Caucasians (low, intermediate and high methylator groups). The TPMT gene promoter contains a variable number of three GC-rich tandem repeats, namely A, B and C, ranging from three to nine in length in a A(n)B(m)C architecture.Here, we ...
Zukić, Branka +10 more
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Duplex pyrosequencing of the TPMT⁎3C and TPMT⁎6 alleles in Korean and Vietnamese populations
Clinica Chimica Acta, 2008Thiopurine S-methyltransferase (TPMT) genetic polymorphisms have been studied intensively in relation to thiopurine toxicity. In the present study, an improved pyrosequencing method was developed for TPMT genotyping and used to investigate the genotype frequency in Korean and Vietnamese populations.Four-hundred Korean and 159 Vietnamese subjects were ...
Jae-Gook Shin, Sang Seop Lee
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Mechanism of allopurinol induced TPMT inhibition
Biochemical Pharmacology, 2013 Up to 1/5 of patients with wildtype thiopurine-S-methyltransferase (TPMT) activity prescribed azathioprine (AZA) or mercaptopurine (MP) demonstrate a skewed drug metabolism in which MP is preferentially methylated to yield methylmercaptopurine (MeMP).
Blaker, P. A. +7 more
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Characterization of Reference Materials for TPMT and NUDT15
The Journal of Molecular Diagnostics, 2022 Pharmacogenetic testing is increasingly provided by clinical and research laboratories; however, only a limited number of quality control and reference materials are currently available for many of the TPMT and NUDT15 variants included in clinical tests.
Victoria M. Pratt +14 more
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Validation of a Genotyping Method for Analysis of TPMT Polymorphisms
Clinical Therapeutics, 2012Thiopurine methyltransferase (TPMT) catalyzes the methylation of thiopurine drugs such as azathioprine and 6-mercaptopurine. Several mutations in the TPMT gene correlate with low enzyme activity and adverse effects such as myelotoxicity. Hence, genotyping TPMT makes it possible to identify patients at high risk for drug toxicity.The aim of this study ...
Francisco Abad-Santos +2 more
exaly +3 more sources