Results 161 to 170 of about 5,467 (204)

6-Mercaptopurine influences TPMT gene Transcription in a TPMT Gene Promoter Variable Number of Tandem Repeats-Dependent Manner

Pharmacogenomics, 2012
Aim: TPMT activity is characterized by a trimodal distribution, namely low, intermediate and high methylator. TPMT gene promoter contains a variable number of GC-rich tandem repeats (VNTRs), namely A, B and C, ranging from three to nine repeats in length
Marianthi Georgitsi, El Mubarak Mohamed Ahmed   +1 more
exaly   +2 more sources

Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19

Biochemical Pharmacology, 2005
Human thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. TPMT is genetically polymorphic and is associated with large interindividual variations in thiopurine drug toxicity and therapeutic efficacy.
Jean-Luc Gala, Delphine Allorge, Franck Broly   +2 more
exaly   +2 more sources

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Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells

Pharmacogenetics, 1999
Inheritance of the TPMT*2, TPMT*3A and TPMT*3C mutant alleles is associated with deficiency of thiopurine S-methyltransferase (TPMT) activity in humans. However, unlike TPMT*2 and TPMT*3A, the catalytically active protein coded by TPMT*3C does not undergo enhanced proteolysis when heterologously expressed in yeast, making it unclear why this common ...
H L, Tai, M Y, Fessing, E J, Bonten, Y, Yanishevsky, A, d'Azzo, E Y, Krynetski, W E, Evans   +6 more
openaire   +2 more sources

Tpmt Gene Expression is Increased During Maintenance Therapy in Childhood Acute Lymphoblastic Leukemia Patients in a TPMT Gene Promoter Variable Number of Tandem Repeat-Dependent Manner

Pharmacogenomics, 2015
Aims: 6-mercaptopurine influences in vitro TPMT gene expression in a TPMT promoter variable number of tandem repeats (VNTR)-dependent manner. We studied TPMT expression following 6-mercaptopurine and methotrexate administration in childhood acute ...
George Patrinos, Nataša Tosic
exaly   +2 more sources

Whose TPMT activity is it anyway?

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2004
Determination of thiopurine S-methyltransferase (TPMT) activity prior to starting azathioprine therapy is used to identify individuals with low or deficient TPMT activities who are at risk of severe complications and even death This case describes a patient treated with azathioprine without prior knowledge of TPMT status ...
Loretta, Ford, Catherine, Prout, Dairena, Gaffney, Jonathan, Berg   +3 more
openaire   +2 more sources

Misinterpretation of TPMT by a DTC Genetic Testing Company

Clinical Pharmacology & Therapeutics, 2014
23andme has suspended marketing of health-related reports due to US Food and Drug Administration approval violations. This has fostered discussions on the actual risks associated with consumer use of these reports. In the case described below, rare genotypes for the gene encoding thiopurine methyltransferase (TPMT) were misinterpreted by a direct-to ...
C A, Brownstein, D M, Margulies, S F, Manzi   +2 more
openaire   +2 more sources

Role of TPMT and ITPA variants in mercaptopurine disposition

Cancer Chemotherapy and Pharmacology, 2018
To explore the levels of thioguanine incorporated into DNA (DNA-TG), and erythrocyte levels of 6-thioguanine nucleotides (Ery-TGN) and methylated metabolites (Ery-MeMP) during 6-mercaptopurine (6MP)/Methotrexate (MTX) therapy of childhood acute lymphoblastic leukemia (ALL) and the relation to inosine triphosphatase (ITPA) and thiopurine ...
Tina Gerbek, Maria Ebbesen, Jacob Nersting, Thomas L. Frandsen, Malin Lindqvist Appell, Kjeld Schmiegelow   +5 more
openaire   +3 more sources

Development of a rapid clinical TPMT genotyping assay

Clinical Biochemistry, 2014
Thiopurine compounds are commonly used in the treatment of childhood acute lymphoblastic leukemia, and as immunosuppressants following organ transplantation or for treatment of various autoimmune disorders. Thiopurine S-methyltransferase (TPMT) is required for detoxification, through S-methylation, of 6-thioguanine nucleotides (TGNs), a byproduct of ...
Paul R. Burchard, Ahmad N. Abou Tayoun, Joel A. Lefferts, Lionel D. Lewis, Gregory J. Tsongalis, Mark A. Cervinski   +5 more
openaire   +2 more sources

TPMT Polymorphism: When Shield Becomes Weakness

Interdisciplinary Sciences: Computational Life Sciences, 2015
Thiopurine methyltransferase (TPMT) is a cytoplasmic transmethylase present in both prokaryotes and eukaryotes. In humans, it shows its presence in almost all of the tissues, predominantly in liver and kidney. TPMT is one of the important metabolic enzymes of phase II metabolic pathway and catalyzes methylation of thiopurine drugs such as azathioprine,
Pramod, Katara, Himani, Kuntal
openaire   +2 more sources

TPMT alleles in the Moroccans

Clinics and Research in Hepatology and Gastroenterology, 2015
Meryem, Janati Idrissi, Imane, Samri, Youssef, Khabbal, Mohammed, El Hassouni, Karim, Ouldim   +4 more
openaire   +2 more sources