Results 151 to 159 of about 4,429 (159)

Fission Yeast Pot1-Tpp1 Protects Telomeres and Regulates Telomere Length

Science, 2008
Telomeres are specialized chromatin structures that protect chromosomal ends. Protection of telomeres 1 (Pot1) binds to the telomeric G-rich overhang, thereby protecting telomeres and regulating telomerase. Mammalian POT1 and TPP1 interact and constitute part of the six-protein shelterin complex.
Tomoichiro, Miyoshi, Junko, Kanoh, Motoki, Saito, Fuyuki, Ishikawa   +3 more
openaire   +2 more sources

Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells

Cell Reports, 2019
Sherilyn Grill, Kamlesh Bisht, Valerie M Tesmer   +2 more
exaly  

POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

EMBO Journal, 2010
Thomas R Cech
exaly  

Suppression of telomere-binding protein TPP1 resulted in telomere dysfunction and enhanced radiation sensitivity in telomerase-negative osteosarcoma cell line

Biochemical and Biophysical Research Communications, 2014
Weiguang Qiang, Fuxiang Zhou, Conghua Xie   +2 more
exaly  

Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis

Rheumatology International, 2011
Yu-Feng Qing, Qi-Bin Yang
exaly  

Homozygous missense TPP1 mutation associated with mild late infantile neuronal ceroid lipofuscinosis and the genotype-phenotype correlation

Seizure: the Journal of the British Epilepsy Association, 2019
De-Tian Liu, Heng Meng, Xiao-Rong Liu
exaly  

TPP1 OB-fold domain protein suppresses cell proliferation and induces cell apoptosis by inhibiting telomerase recruitment to telomeres in human lung cancer cells

Journal of Cancer Research and Clinical Oncology, 2019
Weiran Liu, Hua Zhang, Chenguang Li
exaly  

Characteristics of PPT1 and TPP1 enzymes in neuronal ceroid lipofuscinosis (NCL) 1 and 2 by dried blood spots (DBS) and leukocytes and their application to newborn screening

Molecular Genetics and Metabolism, 2018
Jun Tohyama, Haruo Shintaku
exaly  

Protracted late infantile ceroid lipofuscinosis due to TPP1 mutations: Clinical, molecular and biochemical characterization in three sibs

Journal of the Neurological Sciences, 2015
Raffaella Di Giacopo, Fiorella Piemonte, Andrea Ciolfi   +2 more
exaly