Results 151 to 160 of about 4,795 (186)

Whole-organism screening in a zebrafish model of CLN2 disease identifies pregnenolone as a modulator of lysosomal functions with anti-epileptic properties

Kiani LN, Civiletto G, Lizzo G, Zdebik A, Brickell G, Mahmood F, Nalkos DD, Michaelides L, Eldridge P, Young EM, McPherson H, Campanella M, Gut P, Russell C.   +13 more
europepmc   +1 more source

The protective role of vitamin C in diabetic retinopathy and TPT1 as a potential therapeutic target. [PDF]

Nutr Metab (Lond)
Zhang Y, Li J, Li X, Shao Y.
europepmc   +1 more source

Cross-linked Chitosan-Based Shell with Mirtazapine Lipid Polymer Hybrid Core as Integrated Spray-Dried Bionanocomposites for Boosted Brain-Directed Oral Delivery. [PDF]

Mol Neurobiol
Elbehairy DM, Elmowafy E, Osman R, Sammour OA.   +3 more
europepmc   +1 more source

RFX5 in cancer: context-dependent molecular functions and emerging translational relevance. [PDF]

Front Immunol
Zhang L, Du S, Liu K.
europepmc   +1 more source

Case Report: The window that closed too soon: lessons from a late CLN2 diagnosis and death of a 9-year-old boy. [PDF]

Front Genet
Bryzik A, Larysz D, Larysz P, Karpierz JI, Paprocka J.   +4 more
europepmc   +1 more source

Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models. [PDF]

Sci Transl Med
Ziółkowska EA, Jansen MJ, Williams LL, Wang SH, Eultgen EM, Takahashi K, Le SQ, Nelvagal HR, Sharma J, Sardiello M, DeBosch BJ, Dickson PI, Anderson JB, Sax SE, Wright CM, Bradley RP, Whiteman IT, Makita T, Grider JR, Sands MS, Heuckeroth RO, Cooper JD.   +21 more
europepmc   +1 more source

Comprehensive analysis of single-cell and bulk RNA sequencing data unveils antigen-presenting and processing fibroblasts and establishes a predictive model in gastric cancer. [PDF]

Cancer Cell Int
Zhang C, Chen F, Li J, He Y, Sun J, Zheng Z, Liu G, Wang Y, Kang W, Ye X.   +9 more
europepmc   +1 more source

Novel surgical approach for intraventricular cerliponase alfa enzyme replacement therapy via central venous access device (CVAD) port in neuronal ceroid lipofuscinosis type 2 (CLN2) disease. [PDF]

Childs Nerv Syst
Boop S, Nistal D, Barrios-Anderson A, Cherny WB, Chang IJ, Shelkowitz E, Kho T, Goldstein HE, Hauptman J.   +8 more
europepmc   +1 more source

C1Q⁺ TPP1⁺ macrophages promote colon cancer progression through SETD8-driven p53 methylation. [PDF]

Mol Cancer
Veschi V, Verona F, Di Bella S, Turdo A, Gaggianesi M, Di Franco S, Mangiapane LR, Modica C, Lo Iacono M, Bianca P, Brancato OR, D'Accardo C, Porcelli G, Lentini VL, Sperduti I, Sciacca E, Fitzgerald P, Lopez-Perez D, Martine P, Brown K, Giannini G, Appella E, Stassi G, Todaro M.   +23 more
europepmc   +1 more source

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

Leonard-Booker C, Mazzucco G, Fisher CE, Hussain K, Deegan TD, Doksani Y, Douglas ME.   +6 more
europepmc   +1 more source