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TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity [PDF]

Molecular and Cellular Biology, 2019
TIN2 is an important regulator of telomere length, and mutations in TINF2, the gene encoding TIN2, cause short-telomere syndromes. While the genetics underscore the importance of TIN2, the mechanism through which TIN2 regulates telomere length remains ...
Margaret Strong, Carol Greider, Alexandra Pike   +2 more
exaly   +11 more sources

Multiple facets of TPP1 in telomere maintenance [PDF]

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2014
Telomeres are nucleoprotein complexes that cap the ends of all linear chromosomes and function to prevent aberrant repair and end-to-end chromosome fusions. In somatic cells, telomere shortening is a natural part of the aging process as it occurs with each round of cell division.
Derek Taylor, Malligarjunan Rajavel
exaly   +3 more sources

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TPP1 Inhibits DNA Damage Response and Chemosensitivity in Esophageal Cancer

Critical Reviews in Eukaryotic Gene Expression, 2023
TPP1, as one of the telomere-protective protein complex, functions to maintain telomere stability. In this study, we found that TPP1 was significantly upregulated in esophageal cancer (EC). We found that the proliferation and migration ability were significantly inhibited, while the results of flow cytometry assay indicated that the growth was hindered
Xiaowu Zhong
exaly   +3 more sources

Structural basis of human telomerase recruitment by TPP1-POT1

Science, 2022
Telomerase maintains genome stability by extending the 3′ telomeric repeats at eukaryotic chromosome ends, thereby counterbalancing progressive loss caused by incomplete genome replication. In mammals, telomerase recruitment to telomeres is mediated by TPP1, which assembles as a heterodimer with POT1.
Zala Sekne, George E. Ghanim, Anne-Marie M. van Roon, Thi Hoang Duong Nguyen   +3 more
openaire   +2 more sources

TPP1 as a versatile player at the ends of chromosomes

Frontiers in Biology, 2014
Telomeres, the ends of linear eukaryotic chromosomes, are tandem DNA repeats and capped by various telomeric proteins. These nucleoprotein complexes protect telomeres from DNA damage response (DDR), recombination, and end-to-end fusions, ensuring genome stability.
Sijie Zhang, Zhenhua Luo, Guang Shi, Dan Liu, Zhou Songyang, Junjiu Huang   +5 more
openaire   +1 more source

Multiple POT1–TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA [PDF]

Journal of Molecular Biology, 2011
Telomeres are nucleoprotein complexes that cap and protect the ends of linear chromosomes. In humans, telomeres end in 50–300 nt of G-rich single-stranded DNA (ssDNA) overhangs.
Thomas Cech, Derek Taylor, Dylan Taatjes   +2 more
exaly   +2 more sources

Telomere protection by mammalian Pot1 requires interaction with Tpp1

Nature Structural & Molecular Biology, 2007
The shelterin complex at mammalian telomeres contains the single-stranded DNA-binding protein Pot1, which regulates telomere length and protects chromosome ends. Pot1 binds Tpp1, the shelterin component that connects Pot1 to the duplex telomeric DNA-binding proteins Trf1 and Trf2.
Dirk, Hockemeyer, Wilhelm, Palm, Tobias, Else, Jan-Peter, Daniels, Kaori K, Takai, Jeffrey Z-S, Ye, Catherine E, Keegan, Titia, de Lange, Gary D, Hammer   +8 more
openaire   +2 more sources

Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex [PDF]

Cell Research, 2017
Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-TPP1 heterodimer binds to single-stranded telomeric DNAs, while TRF1 and TRF2-RAP1 interact with double-stranded telomeric DNAs.
Yong Chen, Chunman Zuo, Cayla Broton
exaly   +3 more sources

Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading‐strand replication [PDF]

EMBO Journal, 2011
Eukaryotic up-frameshift 1 (UPF1) is a nucleic acid-dependent ATPase and 5'-to-3' helicase, best characterized for its roles in cytoplasmic RNA quality control. We previously demonstrated that human UPF1 binds to telomeres in vivo and its depletion leads to telomere instability. Here, we show that UPF1 is present at telomeres at least during S and G2/M
Raghav Chawla, Claus Maria Azzalin, Sarantis Gagos   +2 more
exaly   +4 more sources

Role of TRF2 and TPP1 regulation in idiopathic recurrent pregnancy loss

International Journal of Biological Macromolecules, 2019
Telomeres are the tandem repeats (TTAGGG) present at the ends of the chromosomes that ensure chromosome stability and protect chromosomes from degradation. Telomeres in somatic human cells shorten after every cellular division and are linked to the cellular senescence. In this study we have investigated telomere length and expression of shelterin genes
Rameez Hassan Pirzada, Oya Orun, Can Erzik, Huseyin Cagsin, Nedime Serakinci   +4 more
openaire   +3 more sources